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Article
Open AccessThe IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial–mesenchymal transition by phosphorylating β-catenin
Interleukin 33 (IL-33) is a crucial inflammatory factor that functions as an alarm signal in endometriosis (EMs). Epithelial-mesenchymal transition (EMT), a process related to inflammatory signals, intracellul...
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Article
Open AccessPulmonary redox imbalance drives early fibroproliferative response in moderate/severe coronavirus disease-19 acute respiratory distress syndrome and impacts long-term lung abnormalities
COVID-19-associated pulmonary fibrosis remains frequent. This study aimed to investigate pulmonary redox balance in COVID-19 ARDS patients and possible relationship with pulmonary fibrosis and long-term lung a...
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Article
Open AccessAn analysis of adjuvant chemoradiotherapy versus chemotherapy on the survival rates for patients with stage IB-III uterine serous carcinoma
The aim of the present study was to investigate whether a combination of chemotherapy plus radiotherapy was able to increase the overall survival rates compared with chemotherapy alone in stage IB-III uterine ...
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Article
Open AccessBiomechanical effects of Evans versus Hintermann osteotomy for treating adult acquired flatfoot deformity: a patient-specific finite element investigation
Evans and Hintermann lateral column lengthening (LCL) procedures are both widely used to correct adult acquired flatfoot deformity (AAFD), and have both shown good clinical results. The aim of this study was t...
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Article
Open AccessExtracellular succinate derived from ectopic milieu drives adhesion and implantation growth of ectopic endometrial stromal cells via the SUCNR1 signal in endometriosis
As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions. Succinate accumulation in the cytoplasm is co...
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Article
Open AccessEffects of radiotherapy on the survival of patients with stage IA and low-grade stage IB uterine endometrioid carcinoma
The present study aimed to evaluate the effects of radiotherapy on the overall survival of patients with primary stage IA, grade I–III uterine endometrioid carcinoma or stage IB, grade I–II uterine endometrioi...
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Article
Open AccessBaicalein improves the chemoresistance of ovarian cancer through regulation of CirSLC7A6
The present study aimed to investigate whether baicalein improves the sensitivity of resistant ovarian cancer cells to cisplatin.
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Article
Open AccessIron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity
Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron overload occurs in ovarian follicul...
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Article
Open AccessHypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16− NK-cell differentiation
Prostacyclin (PGI2) plays key roles in sha** the immune microenvironment and modulating vasodilation, whereas its contribution to endometriosis (EMs) remains largely unclear. Our study suggested that prostacycl...
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Article
Open AccessClinical risk score for central precocious puberty among girls with precocious pubertal development: a cross sectional study
The gold standard for the diagnosis of central precocious puberty (CPP) is gonadotropin-releasing hormone (GnRH) or GnRH analogs (GnRHa) stimulation test. But the stimulation test is time-consuming and costly....
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Article
Open AccessPatient-specific instrument-assisted minimally invasive internal fixation of calcaneal fracture for rapid and accurate execution of a preoperative plan: A retrospective study
Traditional methods for minimally invasive internal fixation (MIIF) of calcaneal fractures require extensive intraoperative fluoroscopy, and fracture recovery is usually not ideal. We developed a new surgical ...
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Article
Open AccessA comparison between arthroscopic and open surgery for treatment outcomes of chronic lateral ankle instability accompanied by osteochondral lesions of the talus
This study aimed to examine the efficacy and safety of the arthroscopic treatment of osteochondral lesion of talus (OLT) and lateral ankle instability. It was hypothesized that the outcome of all-arthroscopic ...
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Article
Open AccessArthroscopic ankle fusion only has a limited advantage over the open operation if osseous operation type is the same: a retrospective comparative study
A great deal of research suggests that arthroscopic ankle fusion (AAF) has advantages over open ankle fusion (OAF), but these outcomes would be imprecise because of a selection bias. The purpose of this study ...
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Article
Open AccessDesign and evaluation of nano-hydroxyapatite/poly(vinyl alcohol) hydrogels coated with poly(lactic-co-glycolic acid)/nano-hydroxyapatite/poly(vinyl alcohol) scaffolds for cartilage repair
Poly(vinyl alcohol) (PVA) hydrogels have been widely used in synthetic cartilage materials. However, limitations of PVA hydrogels such as poor biomechanics and limited cell ingrowth remain challenges in this f...
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Article
Open AccesskrCRISPR: an easy and efficient strategy for generating conditional knockout of essential genes in cells
CRISPR/Cas9 system is a powerful tool for knocking out genes in cells. However, genes essential for cell survival cannot be directly knocked out. Traditionally, generation of conditional knockout cells require...
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Article
Open AccessAuthor Correction: An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessComparison of collum femoris-preserving stems and ribbed stems in primary total hip arthroplasty
This retrospective study investigated the relative benefits of using a collum femoris-preserving prosthesis or ribbed stem during total hip arthroplasty (THA).
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Article
Crystallization and thermal behavior of recycled polypropylene composites containing nonmetallic printed circuit board powder and β-nucleating agents
A recycled packaging material was found to be a PP copolymer after examinations with DSC, FTIR, and TG techniques. It produced 4.39% residue when heated to 800 °C. In addition, SEM microscopic observations rev...
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Article
Open AccessAn episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells
Human pluripotent stem cells (hPSCs) represent a unique opportunity for understanding the molecular mechanisms underlying complex traits and diseases. CRISPR/Cas9 is a powerful tool to introduce genetic mutati...
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Article
Open Access1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis
Foxp3+ regulatory T (Treg) cells contribute to the local dysfunctional immune environment in endometriosis, an estrogen-dependent gynecological disease, which affects the function of ectopic endometrial tissue cl...
