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Article
Mixed hypogonadism: a neglected combined form of hypogonadism
Kallmann syndrome is a rare disease characterized by delayed puberty, infertility and anosmia. We report the clinical and genetic characteristics of three patients with Kallmann syndrome who presented with Kli...
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Article
Thymoma in multiple endocrine neoplasia type 1: a case report and systematic review
Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome that combines endocrine and non-endocrine tumors. Thymic neuroendocrine tumors are uncommon components that predict poor prognosis in patients with...
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Article
Open AccessAn IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants
Many of the currently available COVID-19 vaccines and therapeutics are not effective against newly emerged SARS-CoV-2 variants. Here, we developed the metallo-enzyme domain of angiotensin converting enzyme 2 (...
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Article
High incidence of hypertension-mediated organ damage in a series of Chinese patients with 17α-hydroxylase deficiency
To analyze the prevalence of hypertension-mediated organ damage (HMOD) and its relationship with enzyme activity of mutant CYP17A1 and other risk factors in patients with 17α-hydroxylase/17,20-lyase deficiency (1...
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Article
Open AccessRapid genomic characterization of SARS-CoV-2 viruses from clinical specimens using nanopore sequencing
The novel SARS-CoV-2 outbreak has swiftly spread worldwide. The rapid genome sequencing of SARS-CoV-2 strains has become a helpful tool for better understanding the genomic characteristics and origin of the vi...
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Article
Combined therapy with GnRH analogue and growth hormone increases adult height in children with short stature and normal pubertal onset
To investigate whether gonadotropin releasing hormone analogue (GnRHa) combined with recombinant human growth hormone (rhGH) can improve the adult height (AHt) of children with short stature and normal puberta...
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Article
The prevalence of heterozygous CYP21A2 deficiency in patients with idiopathic acne, hirsutism, or both
The purpose of this study is to assess the prevalence of heterozygous CYP21A2 mutation and analyze its correlation with clinical manifestation in patients with acne, hirsutism, or both.
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Article
Open AccessEchinochloa crus-galli genome analysis provides insight into its adaptation and invasiveness as a weed
Barnyardgrass (Echinochloa crus-galli) is a pernicious weed in agricultural fields worldwide. The molecular mechanisms underlying its success in the absence of human intervention are presently unknown. Here we re...
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Article
Open AccessGenomic variation associated with local adaptation of weedy rice during de-domestication
De-domestication is a unique evolutionary process by which domesticated crops are converted into ‘wild predecessor like’ forms. Weedy rice (Oryza sativa f. spontanea) is an excellent model to dissect the molecula...
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Article
How does contemporary climate versus climate change velocity affect endemic plant species richness in China?
Climate change is considered a top threat to biodiversity, but the relative roles of contemporary climate versus the rate of climate change in determining spatial patterns of biodiversity are far from clear. C...