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Article
Open AccessExistence and global stability of positive periodic solutions of a discrete predator-prey system with delays
We study the existence and global stability of positive periodic solutions of a periodic discrete predator-prey system with delay and Holling type III functional response. By using the continuation theorem of ...
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Article
Open AccessIn silico discovery of human natural antisense transcripts
Several high-throughput searches for ppotential natural antisense transcripts (NATs) have been performed recently, but most of the reports were focused on cis type. A thorough in silico analysis of human transcri...
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Article
Comparative analysis of whole-genome sequences of Streptococcus suis
The outbreak of Streptococcus suis recently in some districts of Sichuan Province in China has caused over 30 deaths and over 200 infections in human beings. In order to study the pathogenicity mechanism and to p...
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Article
Open AccessDiscovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS)
The liver is the largest human internal organ – it is composed of multiple cell types and plays a vital role in fulfilling the body's metabolic needs and maintaining homeostasis. Of these cell types the hepato...
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Article
Open AccessHuman gene expression sensitivity according to large scale meta-analysis
Genes show different sensitivities in expression corresponding to various biological conditions. Systematical study of this concept is required because of its important implications in microarray analysis etc....
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Article
Open AccessGEOGLE: context mining tool for the correlation between gene expression and the phenotypic distinction
In the post-genomic era, the development of high-throughput gene expression detection technology provides huge amounts of experimental data, which challenges the traditional pipelines for data processing and a...
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Article
Open AccessRevealing parasite influence in metabolic pathways in Apicomplexa infected patients
As an obligate intracellular parasite, Apicomplexa interacts with the host in the special living environment, competing for energy and nutrients from the host cells by manipulating the host metabolism. Previou...
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Article
Open AccessAssociation of tissue lineage and gene expression: conservatively and differentially expressed genes define common and special functions of tissues
Embryogenesis is the process by which the embryo is formed, develops, and establishes developmental hierarchies of tissues. The recent advance in microarray technology made it possible to investigate the tissu...
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Article
Open AccessOptimizing de novo transcriptome assembly from short-read RNA-Seq data: a comparative study
With the fast advances in nextgen sequencing technology, high-throughput RNA sequencing has emerged as a powerful and cost-effective way for transcriptome study. De novo assembly of transcripts provides an import...
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Article
Open AccessAn efficient cluster-based power saving scheme for wireless sensor networks
In this article, efficient power saving scheme and corresponding algorithm must be developed and designed in order to provide reasonable energy consumption and to improve the network lifetime for wireless sens...
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Article
Open AccessA comparative analysis of tissue gene expression data from high-throughput studies
High-throughput technologies were employed over the past decade to study the expression profiles of cells and tissues. There are large collections of accumulated data from public databases and numerous researc...
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Article
Open AccessOptimizing hybrid assembly of next-generation sequence data from Enterococcus faecium: a microbe with highly divergent genome
Sequencing of bacterial genomes became an essential approach to study pathogen virulence and the phylogenetic relationship among close related strains. Bacterium Enterococcus faecium emerged as an important nosoc...
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Article
Open AccessA cross-species analysis method to analyze animal models' similarity to human's disease state
Animal models are indispensable tools in studying the cause of human diseases and searching for the treatments. The scientific value of an animal model depends on the accurate mimicry of human diseases. The pr...
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Article
Open AccessThe genome of Mesobuthus martensii reveals a unique adaptation model of arthropods
Representing a basal branch of arachnids, scorpions are known as ‘living fossils’ that maintain an ancient anatomy and are adapted to have survived extreme climate changes. Here we report the genome sequence of M...
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Article
Open AccessDevelopment of genetically engineered iNKT cells expressing TCRs specific for the M. tuberculosis 38-kDa antigen
The invariant natural killer T (iNKT) cell has been shown to play a central role in early stages immune responses against Mycobacterium tuberculosis (Mtb) infection, which become nonresponsive (anergic) and fails...
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Article
Open AccessExperimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection
Mucosal damage to the gastrointestinal (GI) tract with resulting microbial translocation is hypothesized to significantly contribute to the heightened and persistent chronic inflammation and immune activation ...
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Article
Open AccessThe evolutionary landscape of intergenic trans-splicing events in insects
To explore the landscape of intergenic trans-splicing events and characterize their functions and evolutionary dynamics, we conduct a mega-data study of a phylogeny containing eight species across five orders of ...
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Article
De novo assembly of transcriptome from next-generation sequencing data
Reconstruction of transcriptome by de novo assembly from next generation sequencing (NGS) short-sequence reads provides an essential mean to catalog expressed genes, identify splicing isoforms, and capture the ex...
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Article
Open AccessGlobal transcriptome analysis reveals extensive gene remodeling, alternative splicing and differential transcription profiles in non-seed vascular plant Selaginella moellendorffii
Selaginella moellendorffii, a lycophyte, is a model plant to study the early evolution and development of vascular plants. As the first and only sequenced lycophyte to date, the genome...
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Article
Open AccessIntrafamilial phenotypic heterogeneity in a Taiwanese family with a MAPT p.R5H mutation: a case report and literature review
Frontotemporal degeneration (FTD) is a clinically and genetically heterogeneous neurodegenerative disorder characterized by deficits in executive function that frequently overlaps with parkinsonism and motor n...
