43 Result(s)

Article

Immunological profile of lactylation-related genes in Crohn’s disease: a comprehensive analysis based on bulk and single-cell RNA sequencing data

Crohn's disease (CD) is a disease characterized by intestinal immune dysfunction, often accompanied by metabolic abnormalities. Disturbances in lactate metabolism have been found in the intestine of patients w...

**gtong Wu, Yinyin Lv, Pei Hao, Ziyi Zhang… in Journal of Translational Medicine (2024)

Article

Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity

Monkeypox was declared a global health emergency by the World Health Organization, and as of March 2023, 86,000 confirmed cases and 111 deaths across 110 countries have been reported. Its causal agent, monkeyp...

Niubing Zhang, **ang Cheng, Yilong Zhu, Ouyang Mo… in Science China Life Sciences (2023)

Article

Revealing effective regional decarbonisation measures to limit global temperature increase in uncertain transition scenarios with machine learning techniques

Climate change mitigation scenarios generated by integrated assessment models have been extensively used to support climate change negotiations on the global stage. To date, most studies exploring ensembles of...

Pei-Hao Li, Steve Pye, Ilkka Keppo, Marc Jaxa-Rozen, Evelina Trutnevyte in Climatic Change (2023)

Article

DeepEdit: single-molecule detection and phasing of A-to-I RNA editing events using nanopore direct RNA sequencing

Single-molecule detection and phasing of A-to-I RNA editing events remain an unresolved problem. Long-read and PCR-free nanopore native RNA sequencing offers a great opportunity for direct RNA editing detectio...

Longxian Chen, Liang Ou, **nyun **g, Yimeng Kong, Bingran **e… in Genome Biology (2023)

Article

Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications

Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5⁺ DM) is an autoimmune condition associated with rapidly progressive interstitial lung disease and high mortality. The aetiology and p...

Yan Ye, Zechuan Chen, Shan Jiang, Fengyun Jia, Teng Li, **a Lu… in Nature Communications (2022)

Article

Long-term high-risk drinking does not change effective doses of propofol for successful insertion of gastroscope in Chinese male patients

Available literature indicates that long-term drinkers demand a higher dose of propofol for induction of anesthesia than non-drinkers. However, there is no study having assessed the influence of long-term high...

Pei-Pei Hao, Tian Tian, Bin Hu, Wei-Chao Liu, Ying-Gui Chen… in BMC Anesthesiology (2022)

Article

Direct investigation of the reorientational dynamics of A-site cations in 2D organic-inorganic hybrid perovskite by solid-state NMR

Limited methods are available for investigating the reorientational dynamics of A-site cations in two-dimensional organic–inorganic hybrid perovskites (2D OIHPs), which play a pivotal role in determining their...

Cheng-Chieh Lin, Shing-Jong Huang, Pei-Hao Wu, Tzu-Pei Chen… in Nature Communications (2022)

Article

DENA: training an authentic neural network model using Nanopore sequencing data of Arabidopsis transcripts for detection and quantification of N⁶-methyladenosine on RNA

Models developed using Nanopore direct RNA sequencing data from in vitro synthetic RNA with all adenosine replaced by N⁶-methyladenosine (m⁶A) are likely distorted due to superimposed signals from saturated m⁶A r...

Hang Qin, Liang Ou, Jian Gao, Longxian Chen, Jia-Wei Wang, Pei Hao… in Genome Biology (2022)

Article

Rapid screening and identification of viral pathogens in metagenomic data

Virus screening and viral genome reconstruction are urgent and crucial for the rapid identification of viral pathogens, i.e., tracing the source and understanding the pathogenesis when a viral outbreak occurs....

Shiyang Song, Liangxiao Ma, **ntian Xu, Han Shi, Xuan Li… in BMC Medical Genomics (2021)

Article

Electrically controlled spin polarized current in Dirac semimetals

We propose a highly tunable \(100\%\) 100 % ...

Qianqian Lv, Pei-Hao Fu, **ang-Long Yu, Jun-Feng Liu, Jiansheng Wu in Scientific Reports (2021)

Article

PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation

Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contri...

Jun Yang, Juan Wang, Yuan Liu, Yu Zhang, Wen**g Huang, Yu Zou… in Cell Death & Disease (2021)

Article

scSensitiveGeneDefine: sensitive gene detection in single-cell RNA sequencing data by Shannon entropy

Single-cell RNA sequencing (scRNA-seq) is the most widely used technique to obtain gene expression profiles from complex tissues. Cell subsets and developmental states are often identified via differential gen...

Zechuan Chen, Zeruo Yang, **aojun Yuan, **aoming Zhang, Pei Hao in BMC Bioinformatics (2021)

Article

Do cognitive performance and physical function differ between individuals with motoric cognitive risk syndrome and those with mild cognitive impairment?

Motoric cognitive risk syndrome (MCR) is defined by slow gait speed combined with subjective cognitive complaint. MCR is a predementia syndrome, similar to mild cognitive impairment (MCI). However, there is cu...

Fang-Yu Cheng, Yuanmay Chang, Shih-Jung Cheng, **-Siang Shaw… in BMC Geriatrics (2021)

Article

Interfering with retrotransposition by two types of CRISPR effectors: Cas12a and Cas13a

CRISPRs are a promising tool being explored in combating exogenous retroviral pathogens and in disabling endogenous retroviruses for organ transplantation. The Cas12a and Cas13a systems offer novel mechanisms ...

Niubing Zhang, **nyun **g, Yuanhua Liu, Minjie Chen, **anfeng Zhu… in Cell Discovery (2020)

Article

Investigating UK consumers’ heterogeneous engagement in demand-side response

Demand-side response (DSR), the incentivised time-shifting of energy use by consumers away from peak times, is regarded as a potentially effective measure to balance electricity supply and demand. This will be...

Pei-Hao Li, Ilkka Keppo, Maria Xenitidou, Maria Kamargianni in Energy Efficiency (2020)

Article

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

**ntian Xu, ** Chen, **gfang Wang, Jiannan Feng, Hui Zhou… in Science China Life Sciences (2020)

Article

ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

Induction of long-lived antibody responses during infection or vaccination is often essential for subsequent protection, but the relative contributions of T follicular helper (Tfh) cells and T helper 1 (Th1) c...

Huabin Liang, **yi Tang, Zhihua Liu, Yuanhua Liu, Yuanyuan Huang… in Nature Communications (2019)

Article

Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis

This study aimed to explore the molecular mechanism and clinical relevance of iguratimod in the regulation of human B cell terminal differentiation.

Yan Ye, Mei Liu, Longhai Tang, Fang Du, Yuanhua Liu… in Arthritis Research & Therapy (2019)

Article

Microbiota in the apical root canal system of tooth with apical periodontitis

Apical periodontitis (AP) is essentially an inflammatory disease of microbial etiology primarily caused by infection of the pulp and root canal system. Variation of the bacterial communities caused by AP, as w...

Wenhao Qian, Ting Ma, Mao Ye, Zhiyao Li, Yuanhua Liu, Pei Hao in BMC Genomics (2019)

Article

Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells

In response to myeloablative stresses, HSCs are rapidly activated to replenish myeloid progenitors, while maintaining full potential of self-renewal to ensure life-long hematopoiesis. However, the key factors ...

Xufeng Chen, **gyao Zhao, Chan Gu, Yu Cui, Yuling Dai… in Nature Communications (2018)