1,514 Result(s)

Article

Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress

Ronghua Fang, Jie Chen, Jiangchuan Long, Binghan Zhang, Qixuan Huang… in Biogerontology (2024)

Article

Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway

Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...

Mi Lin, Ru-Hong Tu, Sheng-Ze Wu, Qing Zhong, Kai Weng, Yu-Kai Wu… in Cell Death & Disease (2024)

Article

Biocontrol potential and growth-promoting effect of endophytic fungus Talaromyces muroii SD1-4 against potato leaf spot disease caused by Alternaria alternata

Alternaria alternata is the primary pathogen of potato leaf spot disease, resulting in significant potato yield losses globally. Endophytic microorganism-based biological control, especially using microorganisms ...

Lihua Zhang, Wei Xu, Zhibo Zhao, Youhua Long, Rong Fan in BMC Microbiology (2024)

Article

RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway

Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow transplantation and several hypomethylating agents. However, ...

Li Liu, Chaoying Yang, Lin Zhu, Yanyan Wang, Fuxiang Zheng… in Cell Death & Disease (2024)

Article

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway

Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the develo...

Wenqing Zou, Yiming Lei, Cong Ding, Hongjun **ao, Shunxin Wang… in Cell Death & Disease (2024)

Article

Author Correction: Urbanization, climate and species traits shape mammal communities from local to continental scales

Jeffrey D. Haight, Sharon J. Hall, Mason Fidino… in Nature Ecology & Evolution (2024)

Article

Time since fire affects ecological stoichiometry of plant–soil–microbial systems of Betula platyphylla, a pioneer species in burnt areas of China’s boreal forest

Plant stoichiometry and nutrient allocation may reflect adaptation strategies to environmental nutrient changes. Fire, as a major disturbance in forests, mediates soil nutrient availability that may influence ...

Huiying Cai, Yang Lin, Yatao Liang, Guang Yang, Long Sun in Journal of Forestry Research (2024)

Article

Interconnected lineage trajectories link conventional and natural killer (NK)-like exhausted CD8⁺ T cells beneficial in type 1 diabetes

Distinct Natural Killer (NK)-like CD57⁺ and PD-1⁺ CD8⁺ exhausted-like T cell populations (Tex) have both been linked to beneficial immunotherapy response in autoimmune type 1 diabetes (T1D) patients. The origins ...

Erin M. Witkop, Kirsten Diggins, Alice Wiedeman, Elisavet Serti… in Communications Biology (2024)

Article

Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3

KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how these mutations may shape epigenomic and transcrip...

Marco Seehawer, Zheqi Li, Jun Nishida, Pierre Foidart… in Nature Cell Biology (2024)

Article

Deciphering spatial domains from spatial multi-omics with SpatialGlue

Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integr...

Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng… in Nature Methods (2024)

Article

Comparative Analysis of Seven Endogenous Hormones in a Novel Dual-axillary Bud Mutant Genotype of Sugarcane

The sugarcane genotype YZ 07-86 is a distinct natural mutant with dual-axillary buds. Exploitation of this valuable trait in sugarcane breeding requires an understanding of the physiological mechanism of dual-...

Kamal Priyananda Wickramasinghe, Jun Mao, Chao-hua Xu, **u-qin Lin… in Sugar Tech (2024)

Article

Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor

Bacteria induced metamorphosis observed in nearly all marine invertebrates. However, the mechanism of bacteria regulating the larvae-juvenile metamorphosis remains unknown. Here, we test the hypothesis that c-...

**ao-Meng Hu, Lihua Peng, Yuyi Wang, Fan Ma, Yu Tao… in npj Biofilms and Microbiomes (2024)

Article

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...

Mengqi Li, Yu Wang, **aoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu… in Cell Research (2024)

Article

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs

Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, imp...

Richard H. Chapple, Xueying Liu, Sivaraman Natarajan… in Genome Biology (2024)

Article

A comprehensive analysis of the WRKY family in soybean and functional analysis of GmWRKY164-GmGSL7c in resistance to soybean mosaic virus

Soybean mosaic disease caused by soybean mosaic virus (SMV) is one of the most devastating and widespread diseases in soybean producing areas worldwide. The WRKY transcription factors (TFs) are widely involved in...

Zhihua Zhao, Rongna Wang, Weihua Su, Tianjie Sun, Mengnan Qi, Xueyan Zhang… in BMC Genomics (2024)

Article

Lipidomic signatures in patients with early-onset and late-onset Preeclampsia

Preeclampsia is a pregnancy-specific clinical syndrome and can be subdivided into early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) according to the gestational age of delivery. Patients with ...

Yu Huang, Qiaoqiao Sun, Beibei Zhou, Yiqun Peng, **gyun Li, Chunyan Li… in Metabolomics (2024)

Article

Correction: Roles of estrogen receptors during sexual reversal in pelodiscus sinensis

Guobin Chen, Tong Zhou, Jizeng Cao, **ang Li, Chengjun Zhu… in Molecular Biology Reports (2024)

Article

LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA

Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, po...

**ao-Long Cui, Ji Nie, Houxiang Zhu, Krissana Kowitwanich… in Genome Biology (2024)

Article

Transcriptome analysis reveals the key role of overdominant expression of photosynthetic and respiration-related genes in the formation of tobacco(Nicotiana tabacum L.) biomass heterosis

Leaves are the nutritional and economic organs of tobacco, and their biomass directly affects tobacco yield and the economic benefits of farmers. In the early stage, our research found that tobacco hybrids hav...

Anbin Lu, Shuaibo Zeng, Kai Pi, Benshan Long, Zejun Mo, Renxiang Liu in BMC Genomics (2024)

Article

A genome-wide association study reveals novel loci and candidate genes associated with plant height variation in Medicago sativa

Plant height (PH) is an important agronomic trait influenced by a complex genetic network. However, the genetic basis for the variation in PH in Medicago sativa remains largely unknown. In this study, a comprehen...

Xueqian Jiang, Tianhui Yang, Fei He, Fan Zhang, Xu Jiang, Chuan Wang… in BMC Plant Biology (2024)