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  1. Article

    Open Access

    Deciphering spatial domains from spatial multi-omics with SpatialGlue

    Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integr...

    Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng in Nature Methods (2024)

  2. Article

    Open Access

    A novel circular RNA, circMAML3, promotes tumor progression of prostate cancer by regulating miR-665/MAPK8IP2 axis

    Many studies have now demonstrated that circRNAs are aberrantly expressed in cancer and are involved in the regulation of malignant tumor progression. However, the role of circMAML3 (hsa_circ_0125392) in prost...

    Zeng Zhenhao, Chen Ru, Cheng **aofeng, Yang Heng, Wang Gongxian in Cell Death Discovery (2023)

  3. Article

    Open Access

    Systemic administration of β-glucan induces immune training in microglia

    An innate immune memory response can manifest in two ways: immune training and immune tolerance, which refers to an enhanced or suppressed immune response to a second challenge, respectively. Exposing monocyte...

    Yang Heng, **aoming Zhang, Malte Borggrewe in Journal of Neuroinflammation (2021)

  4. No Access

    Chapter and Conference Paper

    Design and Security Analysis of Certificateless Aggregate Signature Scheme

    The existing certificateless aggregate signature schemes have problems in terms of security and efficiency: some schemes are not secure, which does not satisfy the claimed unforgeability, others are secure, bu...

    Li Cui, Yang Heng, Wu Gang in Artificial Intelligence and Security (2019)

  5. Article

    Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease

    1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model remains the most commonly used animal model of Parkinson's disease (PD). There are three MPTP-treatment schemes: acute, subacute and chronic. Con...

    Qiu-shuang Zhang, Yang Heng, Zheng Mou, Ju-yang Huang in Acta Pharmacologica Sinica (2017)

  6. Article

    Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 cells in vitro

    Accumulation of α-synuclein (α-syn) in the brain is a characteristic of Parkinson's disease (PD). In this study, we investigated whether treatment with tunicamycin, an endoplasmic reticulum (ER) stress inducer...

    Zheng Mou, Yu-he Yuan, Yu-xia Lou, Yang Heng, Ju-yang Huang in Acta Pharmacologica Sinica (2016)

  7. No Access

    Article

    Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA)

    Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. It is a systemic inflammatory disease, characterized by chronic, symmetrical, multi-articular synovial arthritis. IL-25 (IL-17E) is a member of ...

    Wang Kaiwen, Su Zhaoliang, Zhao Yinxia in Rheumatology International (2012)