1,200 Result(s)

Article

Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway

Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...

Mi Lin, Ru-Hong Tu, Sheng-Ze Wu, Qing Zhong, Kai Weng, Yu-Kai Wu… in Cell Death & Disease (2024)

Article

Biocontrol potential and growth-promoting effect of endophytic fungus Talaromyces muroii SD1-4 against potato leaf spot disease caused by Alternaria alternata

Alternaria alternata is the primary pathogen of potato leaf spot disease, resulting in significant potato yield losses globally. Endophytic microorganism-based biological control, especially using microorganisms ...

Lihua Zhang, Wei Xu, Zhibo Zhao, Youhua Long, Rong Fan in BMC Microbiology (2024)

Article

RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway

Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow transplantation and several hypomethylating agents. However, ...

Li Liu, Chaoying Yang, Lin Zhu, Yanyan Wang, Fuxiang Zheng… in Cell Death & Disease (2024)

Article

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway

Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the develo...

Wenqing Zou, Yiming Lei, Cong Ding, Hongjun **ao, Shunxin Wang… in Cell Death & Disease (2024)

Article

Author Correction: Urbanization, climate and species traits shape mammal communities from local to continental scales

Jeffrey D. Haight, Sharon J. Hall, Mason Fidino… in Nature Ecology & Evolution (2024)

Article

Interconnected lineage trajectories link conventional and natural killer (NK)-like exhausted CD8⁺ T cells beneficial in type 1 diabetes

Distinct Natural Killer (NK)-like CD57⁺ and PD-1⁺ CD8⁺ exhausted-like T cell populations (Tex) have both been linked to beneficial immunotherapy response in autoimmune type 1 diabetes (T1D) patients. The origins ...

Erin M. Witkop, Kirsten Diggins, Alice Wiedeman, Elisavet Serti… in Communications Biology (2024)

Article

Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3

KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how these mutations may shape epigenomic and transcrip...

Marco Seehawer, Zheqi Li, Jun Nishida, Pierre Foidart… in Nature Cell Biology (2024)

Article

Deciphering spatial domains from spatial multi-omics with SpatialGlue

Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integr...

Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng… in Nature Methods (2024)

Article

Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor

Bacteria induced metamorphosis observed in nearly all marine invertebrates. However, the mechanism of bacteria regulating the larvae-juvenile metamorphosis remains unknown. Here, we test the hypothesis that c-...

**ao-Meng Hu, Lihua Peng, Yuyi Wang, Fan Ma, Yu Tao… in npj Biofilms and Microbiomes (2024)

Article

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...

Mengqi Li, Yu Wang, **aoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu… in Cell Research (2024)

Article

A comprehensive analysis of the WRKY family in soybean and functional analysis of GmWRKY164-GmGSL7c in resistance to soybean mosaic virus

Soybean mosaic disease caused by soybean mosaic virus (SMV) is one of the most devastating and widespread diseases in soybean producing areas worldwide. The WRKY transcription factors (TFs) are widely involved in...

Zhihua Zhao, Rongna Wang, Weihua Su, Tianjie Sun, Mengnan Qi, Xueyan Zhang… in BMC Genomics (2024)

Article

Transcriptome analysis reveals the key role of overdominant expression of photosynthetic and respiration-related genes in the formation of tobacco(Nicotiana tabacum L.) biomass heterosis

Leaves are the nutritional and economic organs of tobacco, and their biomass directly affects tobacco yield and the economic benefits of farmers. In the early stage, our research found that tobacco hybrids hav...

Anbin Lu, Shuaibo Zeng, Kai Pi, Benshan Long, Zejun Mo, Renxiang Liu in BMC Genomics (2024)

Article

PE/PPE mutations in the transmission of Mycobacterium tuberculosis in China revealed by whole genome sequencing

This study aims to examine the impact of PE/PPE gene mutations on the transmission of Mycobacterium tuberculosis (M. tuberculosis) in China.

Wei-wei Fang, **ang-long Kong, Jie-yu Yang, Ning-ning Tao, Ya-meng Li… in BMC Microbiology (2024)

Article

Author Correction: PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy

Xuefeng Dou, Qiang Fu, Qilai Long, Shuning Liu, Yejun Zou, Da Fu… in Nature Metabolism (2024)

Article

Dynamic Arabidopsis P5CS filament facilitates substrate channelling

In plants, the rapid accumulation of proline is a common response to combat abiotic stress^1–7. Delta-1-pyrroline-5-carboxylate synthase (P5CS) is a rate-limiting enzyme in proline synthesis, catalysing the initia...

Chen-Jun Guo, Tianyi Zhang, Qingqing Leng, **an Zhou, Jiale Zhong… in Nature Plants (2024)

Article

Genome-wide identification and expression analysis of the SPL transcription factor family and its response to abiotic stress in Pisum sativum L

Squamous promoter binding protein-like (SPL) genes encode plant-specific transcription factors (TFs) that play essential roles in modulating plant growth, development, and stress response. Pea (Pisum sativum L.) ...

Long Li, Jian bo Xu, Zhi wen Zhu, Rui Ma, **ao zong Wu, Yu ke Geng in BMC Genomics (2024)

Article

Identification of Eleutherococcus senticosus NAC transcription factors and their mechanisms in mediating DNA methylation of EsFPS, EsSS, and EsSE promoters to regulate saponin synthesis

The formation of pharmacologically active components in medicinal plants is significantly impacted by DNA methylation. However, the exact mechanisms through which DNA methylation regulates secondary metabolism...

**g Dong, Xuelei Zhao, **n Song, Shuo Wang, Xueying Zhao, Baoxiang Liang… in BMC Genomics (2024)

Article

Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing

Diabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened endothelial apoptosis and impaired an...

Peiliang Qin, Peng Zhou, Yating Huang, Binbin Long, Ruikang Gao… in Cell Death Discovery (2024)