179 Result(s)
within
Life Sciences
Human Genetics
**ng Long
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Article
Open AccessAn integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs
Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, imp...
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Open AccessLABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA
Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, po...
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Open AccessStructural variant landscapes reveal convergent signatures of evolution in sheep and goats
Sheep and goats have undergone domestication and improvement to produce similar phenotypes, which have been greatly impacted by structural variants (SVs). Here, we report a high-quality chromosome-level refere...
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Assessing the causal relationship between immune cells and prostatitis: evidence from bidirectional mendelian randomization analysis
Prostatitis represents a common disease of the male genitourinary system, significantly impacting the physical and mental health of male patients. While numerous studies have suggested a potential link between...
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Environmental Effects on Nocturnal Encounters of Two Sympatric Bushbabies, Galago moholi and Otolemur crassicaudatus, in a High-Altitude South African Northern Mistbelt Montane Habitat
Temperate living primates cope with a variety of environmental stressors, which may vary by body mass. We studied two sympatric galagos, the thick-tailed greater galago, Otolemur crassicaudatus (1.5 kg) and the s...
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Open AccessPancreatitis affects gut microbiota via metabolites and inflammatory cytokines: an exploratory two-step Mendelian randomisation study
Previous studies have observed relationships between pancreatitis and gut microbiota; however, specific changes in gut microbiota abundance and underlying mechanisms in pancreatitis remain unknown. Metabolites...
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Open AccessUndetectable off-target effects induced by FokI catalytic domain in mouse embryos
The FokI catalytic domain can be fused to various DNA binding architectures to improve the precision of genome editing tools. However, evaluation of off-target effects is essential for develo** these tools. ...
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Integration of genome-wide association studies reveal loci associated with salt tolerance score of rice at the seedling stage
Salt threatens rice cultivation in many countries. Hence, breeding new varieties with high salt tolerance is important.
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Ongoing Bidirectional Introgression and the Maintenance of Species Boundaries in Hemiculter Hybrid Zone
The proper delimitation of species plays an important role in taxonomy as well as in studies related to speciation. However, introgressive hybridization can confuse our ability to accurately construct phylogen...
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Open AccessSeasonal Effects on the Fecal Microbial Composition of Wild Greater Thick-Tailed Galagos (Otolemur crassicaudatus)
Bacterial communities present in the host digestive tract are important for the breakdown and absorption of nutrients required by the host. Changes in diet and the environment are major factors affecting the c...
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Characterization and diversity of CRISPR/Cas systems in Klebsiella oxytoca
CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) system is a crucial adaptive immune system for bacteria to resist foreign DNA infection. In this study, we inv...
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Allometric brain reduction in an insular, dwarfed population of black-tailed deer
Insular populations of mammals have been shown to undergo drastic morphological changes relative to mainland counterparts, and these adaptations can provide insight into the evolutionary effects of predation a...
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Open AccessEffective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes
RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues a...
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Open AccessPlasma cell-free DNA promise monitoring and tissue injury assessment of COVID-19
Coronavirus 2019 (COVID-19) is a complex disease that affects billions of people worldwide. Currently, effective etiological treatment of COVID-19 is still lacking; COVID-19 also causes damages to various orga...
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Open AccessCharacterization of novel loci controlling seed oil content in Brassica napus by marker metabolite-based multi-omics analysis
Seed oil content is an important agronomic trait of Brassica napus (B. napus), and metabolites are considered as the bridge between genotype and phenotype for physical traits.
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Transcriptomic profiling of the cold stress and recovery responsiveness of two contrasting Guizhou HE rice genotypes
At the seed germination stage, rice is sensitive to cold stress, which adversely affects its growth and development. Guizhou HE rice comprises several different landraces, most of which are cold tolerant.
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Comparative transcriptome analysis to reveal key ethylene genes involved in a Lonicera macranthoides mutant
Lonicera macranthoides Hand.-Mazz. is an important medicinal plant. **anglei-type (XL) L. macranthoides was formed after many years of cultivation by researchers on the basis of the natural mutant. The corolla of...
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Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to promote a cancer stem cell phenotype in hepatocellular carcinoma
Deubiquitinating enzymes (DUBs) have been shown to be possible targets for hepatocellular carcinoma (HCC) treatment.
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Methylophiopogonanone a Inhibits LPS/ATP-Induced Macrophage Pyroptosis via ROS/NLRP3 Pathway
As a byproduct of mitochondrial respiration or metabolism, reactive oxygen species (ROS) can act as a signaling molecule to activate NLR family pyrin domain containing 3 (NLRP3) inflammasome, thereby triggerin...
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Open AccessDynamic chromatin regulatory programs during embryogenesis of hexaploid wheat
Plant and animal embryogenesis have conserved and distinct features. Cell fate transitions occur during embryogenesis in both plants and animals. The epigenomic processes regulating plant embryogenesis remain ...
