95 Result(s)

Article

Prognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy

The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...

Cheng-Fei Du, Zhen-Yu Gao, Zhu-Ding Xu, Zheng-Kang Fang, Zi-Chen Yu… in BMC Cancer (2024)

Article

Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...

Yue Zeng, Chun-Hong Hu, Yi-Zheng Li, Jian-Song Zhou, Shu-**ng Wang… in Nature Medicine (2024)

Article

CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis

The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed in HCC cases through bioinformatics analysis. This ...

**ao-Yu Zhang, Shan-Shan Li, Yu-Rong Gu, Le-**n **ao, **n-Yi Ma… in Molecular Cancer (2024)

Article

The selective sponging of miRNAs by OIP5-AS1 regulates metabolic reprogramming of pyruvate in adenoma-carcinoma transition of human colorectal cancer

RNA interactomes and their diversified functionalities have recently benefited from critical methodological advances leading to a paradigm shift from a conventional conception on the regulatory roles of RNA in...

**g-Yu Wang, **ao-** Zhang, Hong-Kun Zhou, Hong-**n Cai, **-Biao Xu… in BMC Cancer (2024)

Article

Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Shu-Qiang Yuan, Run-Cong Nie, Ying **, Cheng-Cai Liang, Yuan-Fang Li… in Nature Medicine (2024)

Article

Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...

Guo-Tian Ruan, Li Deng, Hai-Lun **e, **-Yu Shi, **ao-Yue Liu… in Cancer & Metabolism (2024)

Article

Mutation status of the KMT2 family associated with immune checkpoint inhibitors (ICIs) therapy and implicating diverse tumor microenvironments

Mounting evidence suggests a strong association between tumor immunity and epigenetic regulation. The histone-lysine N-methyltransferase 2 (KMT2) family plays a crucial role in the methylation of histone H3 at...

Dong-Xu Wang, Jun-Yu Long, Rui-Zhe Li, Dao-Lin Zhang, Hui Liu… in Molecular Cancer (2024)

Article

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang… in Genome Medicine (2024)

Article

Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2

The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, of...

Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu… in BMC Cancer (2023)

Article

Retraction Note: A synthetic dsRNA, as a TLR3 pathwaysynergist, combined with sorafenib suppresses HCC in vitro and in vivo

Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-**n Zhang, Yin-Ze Wei… in BMC Cancer (2023)

Article

Integrated analysis of intratumoral biomarker and tumor-associated macrophage to improve the prognosis prediction in cancer patients

The lack of effective and accurate predictive indicators remains a major bottleneck for the improvement of the prognosis of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Hepatit...

Ming-Da Wang, Hao **ang, Tian-Yu Hong, Abudurexiti Mierxiati, Fei-Hu Yan… in BMC Cancer (2023)

Article

Spatial analysis of stromal signatures identifies invasive front carcinoma-associated fibroblasts as suppressors of anti-tumor immune response in esophageal cancer

Increasing evidence indicates that the tumor microenvironment (TME) is a crucial determinant of cancer progression. However, the clinical and pathobiological significance of stromal signatures in the TME, as a...

Jian-Zhong He, Yang Chen, Fa-Min Zeng… in Journal of Experimental & Clinical Cancer … (2023)

Article

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases ...

Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang… in Genome Medicine (2023)

Article

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in...

Marie-Gabrielle Duperron, Maria J. Knol, Quentin Le Grand… in Nature Medicine (2023)

Article

Publisher Correction: A T cell resilience model associated with response to immunotherapy in multiple tumor types

Yu Zhang, Trang Vu, Douglas C. Palmer, Rigel J. Kishton, Lanqi Gong… in Nature Medicine (2022)

Article

Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao… in Journal of Experimental & Clinical Cancer … (2022)

Article

Current status of neoadjuvant therapy for locally advanced rectal cancer in Wuhan Union Hospital Cancer Center

To analyze and explore the evolution and short-term efficacy of neoadjuvant therapy for patients with mid and low LARC in Wuhan Union Hospital Cancer Center.

Meng-Lan Zhai, Fang-Yuan Zhang, **-Ru Yang, Sheng Zhang, Lei Zhao… in Radiation Oncology (2022)

Article

Targeting TROY-mediated P85a/AKT/TBX3 signaling attenuates tumor stemness and elevates treatment response in hepatocellular carcinoma

Previous in vitro hepatocyte differentiation model showed that TROY was specifically expressed in liver progenitor cells and a small proportion of hepatocellular carcinoma cells, suggesting that TROY may parti...

Beilei Liu, **aona Fang, Dora Lai-Wan Kwong… in Journal of Experimental & Clinical Cancer … (2022)

Article

KMT2B promotes the growth of renal cell carcinoma via upregulation of SNHG12 expression and promotion of CEP55 transcription

This study aims to clarify the mechanistic action of long non-coding RNA (lncRNA) SNHG12 in the development of renal cell carcinoma (RCC), which may be associated with promoter methylation modification by KMT2...

Jia-fu Feng, Jun Wang, Gang **e, Yao-dong Wang, **ao-han Li… in Cancer Cell International (2022)

Article

Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway

Triple negative breast cancer (TNBC) is highly malignant and has a worse prognosis, compared with other subtypes of breast cancer due to the absence of therapeutic targets. KIF23 plays a crucial role in the tu...

Zhi Li, Hai-Yan Yang, **ao-Lan Zhang… in Journal of Experimental & Clinical Cancer … (2022)