-
Article
Open AccessAmino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice
H7N9 subtype avian influenza viruses (AIVs) cause 1567 human infections and have high mortality, posing a significant threat to public health. Previously, we reported that two avian-derived H7N9 isolates (A/ch...
-
Article
Open AccessComparative policy analysis of national rare disease funding policies in Australia, Singapore, South Korea, the United Kingdom and the United States: a sco** review
Rare diseases pose immense challenges for healthcare systems due to their low prevalence, associated disabilities, and attendant treatment costs. Advancements in gene therapy, such as treatments for Spinal Mus...
-
Article
Open AccessDevelo** a production workflow for 3D-printed temporal bone surgical simulators
3D-printed temporal bone models enable the training and rehearsal of complex otological procedures. To date, there has been no consolidation of the literature regarding the developmental process of 3D-printed ...
-
Article
Open AccessIsolated flat band in artificially designed Lieb lattice based on macrocycle supramolecular crystal
Isolated flat bands are known to host various strongly correlated phases due to the enhanced Coulomb interactions when the flat bands are gapped from dispersive bands. One way to achieve an isolated flat band ...
-
Article
Open AccessPredicting factors for acute encephalopathy in febrile seizure children with SARS-CoV-2 omicron variant: a retrospective study
SARS-CoV-2 posed a threat to children during the early phase of Omicron wave because many patients presented with febrile seizures. The study aimed to investigate predicting factors for acute encephalopathy of...
-
Article
The economic burden of inherited retinal disease in Singapore: a prevalence-based cost-of-illness study
To assess the economic impact of inherited retinal disease (IRD) among Singaporeans.
-
Article
Open AccessComparative study on main compounds and hypoglycemic effects of dispensing granules of Coptidis Rhizoma and Scutellaria–Coptis herb couple with traditional decoction
The clinical applications of dispensing granules (DG) have increased dramatically. However, it is controversial whether the DG has the same quality and efficacy compared with traditional decoction (TD). In thi...
-
Article
Open AccessTargeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats
The dysregulation of local circadian clock has been implicated in the pathogenesis of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks Rev-Erbα in ischemia-reper...
-
Article
Open AccessA novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example
The oral bioavailability and blood–brain barrier permeability of many herbal products are too low to explain the significant efficacy fully. Gut microbiota and liver can metabolize herbal ingredients to more a...
-
Article
Two patients with KDM3B variants and new presentations of Diets–Jongmans syndrome
KDM3B is located on chromosome 5q31 and encodes KDM3B, which is involved in histone demethylation and epigenetic regulation. Pathogenic KDM3B variants cause a dominantly inherited disorder presenting with intelle...
-
Article
Open AccessOn-surface synthesis and spontaneous segregation of conjugated tetraphenylethylene macrocycles
Creating conjugated macrocycles has attracted extensive research interest because their unique chemical and physical properties, such as conformational flexibility, intrinsic inner cavities and aromaticity/ant...
-
Article
Open AccessLocally invasive recurrence or metastasis of pheochromocytoma into the liver?—clinicopathological challenges
Pheochromocytomas (PCC) are rare and functional neuroendocrine tumors develo** from adrenal chromaffin cells. Predicting malignant behavior especially in the absence of metastasis can be quite challenging ev...
-
Article
Open AccessAssociation between socioeconomic status and severity of oral epithelial dysplasia using a Taiwanese Nationwide Oral Mucosal Screening Program: a retrospective analysis
The study aimed to investigate the association between socioeconomic status and severity of oral epithelial dysplasia (OED) using current data from the Taiwanese Nationwide Oral Mucosal Screening Program (TNOM...
-
Article
Open AccessGrowth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma
Tumour lineage plasticity is an emerging hallmark of aggressive tumours. Tumour cells usually hijack developmental signalling pathways to gain cellular plasticity and evade therapeutic targeting. In the presen...
-
Article
Qaidamihabitans albus gen. nov., sp. nov., a new member of the family Pseudonocardiaceae, and transfer of Prauserella shu**wangii to Qaidamihabitans gen. nov. as Qaidamihabitans shu**wangii comb. nov.
A novel mycelium-forming actinomycete strain, designated YIM S01255T were isolated from a salt lake. Optimal growth occurred in the presence of 0–5.0% (w/v) NaCl, at pH 7.0–8.0, and at 37 °C. Strain YIM S01255T c...
-
Article
A natural nanozyme in life is found: the iron core within ferritin shows superoxide dismutase catalytic activity
-
Article
Open AccessA novel nonsense variant of the AGXT identified in a Chinese family: special variant research in the Chinese reference genome
Primary hyperoxaluria(PH)is a rare autosomal recessive genetic disease that contains three subtypes (PH1, PH2 and PH3). Approximately 80% of PH patients has been reported as subtype PH1, this subtype of PH has...
-
Chapter and Conference Paper
Resiliency of Power Grid Infrastructure Under Extreme Hazards - Observations and Lessons Learned from Hurricane Maria in Puerto Rico
On the morning of Wednesday, September 20, 2017, Hurricane Maria made landfall near the southeastern town of Yabucoa, Puerto Rico (PR), as a powerful Category 4 storm on the Saffir-Simpson hurricane wind scale...
-
Article
Click-ExM enables expansion microscopy for all biomolecules
Expansion microscopy (ExM) allows super-resolution imaging on conventional fluorescence microscopes, but has been limited to proteins and nucleic acids. Here we develop click-ExM, which integrates click labeli...
-
Article
Identification of prognostic claudins signature in hepatocellular carcinoma from a hepatocyte differentiation model
Loss of terminal differentiation markers and gain of stem cell-like properties are a major hallmark of cancer malignant progression. Identification of novel biomarkers representing tumor developmental progeny ...
