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Article
Open AccessGrowth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma
Tumour lineage plasticity is an emerging hallmark of aggressive tumours. Tumour cells usually hijack developmental signalling pathways to gain cellular plasticity and evade therapeutic targeting. In the presen...
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Article
Identification of prognostic claudins signature in hepatocellular carcinoma from a hepatocyte differentiation model
Loss of terminal differentiation markers and gain of stem cell-like properties are a major hallmark of cancer malignant progression. Identification of novel biomarkers representing tumor developmental progeny ...
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Article
Open AccessLncRNA AC093818.1 accelerates gastric cancer metastasis by epigenetically promoting PDK1 expression
Gastric cancer (GC) is a highly prevalent type of metastatic tumor. The mechanisms underlying GC metastasis are poorly understood. Some long noncoding RNAs (lncRNAs) reportedly play key roles in regulating met...
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Article
Open AccessDevelopment of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma
Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression. The stem cell pluripotent transcriptional factor SOX family play cri...
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Article
Open AccessEndothelial progenitor cells in cardiovascular diseases: from biomarker to therapeutic agent
Regenerative medicine techniques to recover cardiac and vascular function are being increasingly investigated as management strategies for cardiovascular diseases. Circulating endothelial progenitor cells (EPC...
