83 Result(s)
within
**n-Yang Lu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
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Open AccessAuthor Correction: Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats’ choroid plexus
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Open AccessDeficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion
The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identif...
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Open AccessArchitecture of symbiotic dinoflagellate photosystem I–light-harvesting supercomplex in Symbiodinium
Symbiodinium are the photosynthetic endosymbionts for corals and play a vital role in supplying their coral hosts with photosynthetic products, forming the nutritional foundation for high-yield coral reef ecosyst...
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Open AccessGlobal fungal-host interactome map** identifies host targets of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...
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Open AccessDipterocarpoidae genomics reveal their demography and adaptations to Asian rainforests
Dipterocarpoideae species form the emergent layer of Asian rainforests. They are the indicator species for Asian rainforest distribution, but they are severely threatened. Here, to understand their adaptation ...
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Open AccessExperimental evidence for cancer resistance in a bat species
Mammals exhibit different rates of cancer, with long-lived species generally showing greater resistance. Although bats have been suggested to be resistant to cancer due to their longevity, this has yet to be s...
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Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
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Open AccessPIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target
Gastric cancer (GC) is one of the most prevalent malignant tumors of the gastrointestinal system in the globe. The effect of PIEZO2 on the immune function and pathological features of gastric cancer remains to...
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Open AccessTailoring chemical composition of solid electrolyte interphase by selective dissolution for long-life micron-sized silicon anode
Micron-sized Si anode promises a much higher theoretical capacity than the traditional graphite anode and more attractive application prospect compared to its nanoscale counterpart. However, its severe volume ...
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Open AccessA single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia
Achalasia is a rare motility disorder of the esophagus caused by the gradual degeneration of myenteric neurons. Immune-mediated ganglionitis has been proposed to underlie the loss of myenteric neurons. Here, w...
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Open AccessVisualizing the multi-level assembly structures of conjugated molecular systems with chain-length dependent behavior
It remains challenging to understand the structural evolution of conjugated polymers from single chains to solvated aggregates and film microstructures, although it underpins the performance of optoelectrical ...
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Open AccessTranscriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats’ choroid plexus
Manganese dioxide nanoparticles (MnO2-NPs) have a wide range of applications in biomedicine. Given this widespread usage, it is worth noting that MnO2-NPs are definitely toxic, especially to the brain. However, ...
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Open AccessCellular differentiation into hyphae and spores in halophilic archaea
Several groups of bacteria have complex life cycles involving cellular differentiation and multicellular structures. For example, actinobacteria of the genus Streptomyces form multicellular vegetative hyphae, aer...
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Open AccessAllele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine...
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Open AccessAerobic oxidation of methane significantly reduces global diffusive methane emissions from shallow marine waters
Methane is supersaturated in surface seawater and shallow coastal waters dominate global ocean methane emissions to the atmosphere. Aerobic methane oxidation (MOx) can reduce atmospheric evasion, but the magni...
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Open AccessA cross-sectional study of Chinese women facial skin status with environmental factors and individual lifestyles
Geographical, environmental and pollution conditions affect facial skin health, but their effects on skin appearance have not been elucidated. This study aimed to describe the skin barrier and skin tone charac...
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Free-space dissemination of time and frequency with 10−19 instability over 113 km
Networks of optical clocks find applications in precise navigation1,2, in efforts to redefine the fundamental unit of the ‘second’3–6 and in gravitational tests7. As the frequency instability for state-of-the-art...
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Open AccessCare cascade of tuberculosis infection treatment for people living with HIV in the era of antiretroviral therapy scale-up
Testing and treatment of tuberculosis infection (TBI) are recommended for people living with HIV (PLWH). We aimed to evaluate the care cascade of TBI treatment among PLWH in the era of antiretroviral therapy (...
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Open AccessMain-chain engineering of polymer photocatalysts with hydrophilic non-conjugated segments for visible-light-driven hydrogen evolution
Photocatalytic water splitting is attracting considerable interest because it enables the conversion of solar energy into hydrogen for use as a zero-emission fuel or chemical feedstock. Herein, we present a un...
