59 Result(s)

Article

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...

Mengqi Li, Yu Wang, **aoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu… in Cell Research (2024)

Article

The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway

Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells and plays an important role in the occurrence and dev...

Jun-Jun Chen, Tian-Zhu Lu, Tao Wang, Wen-Hui Yan, Fang-Yan Zhong… in Cell Death & Disease (2024)

Article

Adeno-associated virus as a delivery vector for gene therapy of human diseases

Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombin...

Jiang-Hui Wang, Dominic J. Gessler, Wei Zhan… in Signal Transduction and Targeted Therapy (2024)

Article

HMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis

Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying ch...

**g-Yu Yang, **n-Yuan Lei, Kai-Yue He, **-Rong Guo, Meng-Jie Liu… in Cell Death & Disease (2024)

Article

Faecalibacterium prausnitzii as a potential Antiatherosclerotic microbe

The gut microbiota plays a crucial role in coronary artery disease (CAD) development, but limited attention has been given to the role of the microbiota in preventing this disease. This study aimed to identify...

Hai-Tao Yang, Zhi-hui Jiang, Yi Yang, Ting-Ting Wu… in Cell Communication and Signaling (2024)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)

Article

BRD4770 inhibits vascular smooth muscle cell proliferation via SUV39H2, but not EHMT2 to protect against neointima formation

The behavior of vascular smooth muscle cells (VSMCs) contributes to the formation of neointima. We previously found that EHMT2 suppressed autophagy activation in VSMCs. BRD4770, an inhibitor of EHMT2/G9a, play...

Tai-Qiang Chen, **an Guo, Bo Huo, **ao-Xuan Zhong, Qun-Hui Wang, Yue Chen… in Human Cell (2023)

Article

LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney cancer. However, its role in kidney tumorigenesis remains unk...

Jun Lu, Liang-min Fu, Yun Cao, Yong Fang, Jia-zheng Cao, Yi-hui Pan… in Oncogene (2023)

Article

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to ...

Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, **aopeng Luo… in Cell Discovery (2023)

Article

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly exp...

Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu… in Cell Research (2022)

Article

PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy

A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients’ response t...

Min Huang, Fang He, Dan Li, Ya-Jia **e, Ze-Bo Jiang, Ju-Min Huang… in Cell Death & Disease (2022)

Article

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells

Qun Chu, Feifei Liu, Yifang He, **aoyu Jiang, Yusheng Cai, Zeming Wu… in Protein & Cell (2022)

Article

ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed that irreversible myoca...

**ao-Hui Ma, Jiang-Han-Zi Liu, Chun-Yu Liu… in Signal Transduction and Targeted Therapy (2022)

Article

BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific ...

**u-**u Liu, **ng-Hui Chen, Zhi-Wei Zheng… in Signal Transduction and Targeted Therapy (2022)