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Article
Prediction of Bone Remodeling in Rat Caudal Vertebrae Based on Fluid-Solid Coupling Simulation
Some previous researches have demonstrated that appropriate mechanical stimulation can enhance bone formation. However, most studies have employed the strain energy density (SED) method for predicting bone rem...
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Article
Open AccessEffects of poling camber angle on the biomechanics of cross-country sit-skiing
Cross-country sit-skiers use double poling (DP) technique to drive the slide. The aim of this study is to analyze how poling camber angle affect the capacity of power output and biomechanical parameters of the...
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Article
Open AccessBRD4770 inhibits vascular smooth muscle cell proliferation via SUV39H2, but not EHMT2 to protect against neointima formation
The behavior of vascular smooth muscle cells (VSMCs) contributes to the formation of neointima. We previously found that EHMT2 suppressed autophagy activation in VSMCs. BRD4770, an inhibitor of EHMT2/G9a, play...
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Article
Open AccessThe roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1
Aberrant proliferation of vascular smooth muscle cells (VSMCs) is the cause of neointima formation followed by vascular injury. Autophagy is involved in this pathological process, but its function is controver...
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Article
Open AccessHistone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis
E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase, contributes to modifications of the chromatin landscape of genes involved in multiple cardiovascular diseases. Ferroptosis of vas...
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Article
Detection of the effect of microvibrational stimulation on human discarded immature oocytes by single-cell transcriptome sequencing technology
This study aimed to investigate the changes in oocytes at the transcriptome level after applying continuous microvibrational mechanical stimulation to human immature oocytes during in vitro maturation.
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Article
Open AccessAn integrated evaluation approach of wearable lower limb exoskeletons for human performance augmentation
Wearable robots have been growing exponentially during the past years and it is crucial to quantify the performance effectiveness and to convert them into practical benchmarks. Although there exist some common...
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Article
Bilateral upper extremity trunk model for cross-country sit-skiing double poling propulsion: model development and validation
The subacromial im**ement syndrome is a high-incidence injury for cross-country sit-skiing skier, which is often accompanied by muscle imbalance. However, at present, no musculoskeletal model has been identi...
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Article
Finite element analysis on mechanical state on the osteoclasts under gradient fluid shear stress
Mechanical loading, such as fluid shear stress (FSS), is regarded as the main factor that regulates the biological responses of bone cells. Our previous studies have demonstrated that the RAW264.7 osteoclast p...
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Article
Regulation of substrate surface topography on differentiation of mesenchymal stem cells
Mesenchymal stem cells (MSCs) have been extensively used in the field of tissue engineering and regenerative medicine. The effect of surface properties on the differentiation of MSCs is a very important issue ...
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Article
Cell–substrate traction force regulates the fusion of osteoclast precursors through cell–cell interaction
The adhesion morphology of a cell monolayer results in a mechanical force inside cells, between cells, or between cells and substrates. The mechanical force regulates the differentiation of stem cells, but its...
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Article
Spreading Shape and Area Regulate the Osteogenesis of Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) have strong self-renewal ability and multiple differentiation potential. Some studies confirmed that spreading shape and area of single MSCs influence cell differentiation, but fe...
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Article
Migration and differentiation of osteoclast precursors under gradient fluid shear stress
The skeleton can adapt to mechanical loading through bone remodeling, and osteoclasts close to microdamages are believed to initiate bone resorption. However, whether local mechanical loading, such as fluid fl...
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Article
Open AccessHDAC6 is associated with the formation of aortic dissection in human
The pathological features of aortic dissection (AD) include vascular smooth muscle cell (VSMC) loss, elastic fiber fraction, and inflammatory responses in the aorta. However, little is known about the post-tra...
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Article
Open AccessEZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection
Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di- and tri-methylates lysine-27 of histone H3, largely functions as a transcriptional repressor, and plays a critical role in various kinds of canc...
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Article
Open AccessAberrant Epicardial Adipose Tissue Extracellular Matrix Remodeling in Patients with Severe Ischemic Cardiomyopathy: Insight from Comparative Quantitative Proteomics
There is ample evidence indicating that epicardial adipose tissue (EAT) volume and thickness is positively associated with coronary artery disease (CAD). However, the exact pathological changes in the human EA...
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Article
Flow-Induced Migration of Osteoclasts and Regulations of Calcium Signaling Pathways
Osteoclasts are large multinucleate cells originating from the fusion of monocytes that are differentiated from hematopoietic stem cells. Although activated osteoclasts preferentially move to the area of micro...
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Article
Open AccessStiff substrates enhance cultured neuronal network activity
The mechanical property of extracellular matrix and cell-supporting substrates is known to modulate neuronal growth, differentiation, extension and branching. Here we show that substrate stiffness is an import...
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Article
Fluid Flow-Induced Calcium Response in Osteoclasts: Signaling Pathways
Intracellular calcium oscillation and its downstream signaling in osteoclasts is believed to play critical roles in regulating bone resorption. Our previous study demonstrated that fluid shear stress (FSS) ind...
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Article
Probing the mechanosensitivity in cell adhesion and migration: Experiments and modeling
Cell adhesion and migration are basic physiological processes in living organisms. Cells can actively probe their mechanical micro-environment and respond to the external stimuli through cell adhesion. Cells n...
