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1,154 Result(s)
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Article
Open AccessPredictive value of MRI-based deep learning model for lymphovascular invasion status in node-negative invasive breast cancer
To retrospectively assess the effectiveness of deep learning (DL) model, based on breast magnetic resonance imaging (MRI), in predicting preoperative lymphovascular invasion (LVI) status in patients diagnosed ...
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Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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Article
Resolution of anti-LGI1-associated autoimmune encephalitis in a patient after treatment with efgartigimod
Anti leucine-rich, glioma inactivated 1 (LGI1) antibody-associated autoimmune encephalitis (AE) is the second most common AE, where the trafficking and recycling of the pathogenic immunoglobulin (IgG) can be c...
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Open AccessDissecting the vascular-cognitive nexus: energetic vs. conventional hemodynamic parameters
Blood pressure or flow measurements have been associated with vascular health and cognitive function. We proposed that energetic hemodynamic parameters may provide a more nuanced understanding and stronger cor...
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Open AccessExperimental study on the biomechanical stability of complex acetabular fractures in the quadrilateral area: application of a dynamic anterior titanium-plate screw system
Complex acetabular fractures involving quadrilateral areas are more challenging to treat during surgery. To date, there has been no ideal internal fixation for these acetabular fractures. The purpose of this s...
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Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy
Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs) are among the most devastating symptoms of patients with hereditary hemorrhagic telangiectasis (HHT). All available managem...
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Prior herpes zoster occurrence and high-dose corticosteroids increase herpes zoster risk in rheumatoid arthritis patients receiving janus kinase inhibitors in a retrospective and observational study
Herpes zoster (HZ) risk is increased in rheumatoid arthritis (RA) patients receiving Janus kinase inhibitors (JAKi) therapy. Identifying and evaluating the risk factors of HZ development in patients receiving ...
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Clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma
The clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma (ND-DLBCL) remains largely unexplored. One hundred ND-DLBCL patients were consecutively enrolled as training c...
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Assessing the range of blasting-induced cracks in the surrounding rock of deeply buried tunnels based on the unified strength theory
Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse, posing significant safety risks. However, previous theoretical studies on the range of ...
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Article
Analysis of CCND3 mutations in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), accounts for 30–40% of newly diagnosed lymphomas, has an overall cure rate of approximately 60%. Despite previous reports suggesting a negative prognostic association bet...
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Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Cooperative enhancement of mechanical and tribological properties through tailoring TiN transition interface in boron nitride nanosheets reinforced copper composites
Strengthening interface bonding between boron nitride nanosheets (BNNS) and copper matrix is an essential prerequisite for exploiting a new generation of copper matrix composites (CMCs) with high strength and ...
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Open AccessAssociation between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer
Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...
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Phase modulation of nickel-tin alloys in regulating electrocatalytic nitrogen reduction properties
电催化氮还原反应(NRR)是在常规条件下合成氨(NH3)的一种有效方法,但其催化性能(例如:选择性、催化效率等)在很大程度上取决于催化剂的物理性质。在本工作中,物理性能可控的Ni-Sn 合金纳米粒子通过简单的两步法成功合成,并将其用作 NRR 的高效电催化剂。通过调控Ni : Sn的原子比例,分别构建了不同物相的Ni-Sn合金,包括:Ni、Ni-Ni3Sn、Ni3Sn、Ni3Sn2、Ni3Sn4和Sn,其中Ni3Sn合金...
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Article
Damage Recognition of Acoustic Emission and Micro-CT Characterization of Bi-adhesive Repaired Composites Based on the Machine Learning Method
Bi-adhesive repair method is one of several repair technologies that use the adhesive bonding approach for patch-repaired composites. However, these repairs are subject to matrix-cracking and interface debondi...
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Open AccessCritical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury
Maleic acid (MA) induces renal tubular cell dysfunction directed to acute kidney injury (AKI). AKI is an increasing global health burden due to its association with mortality and morbidity. However, targeted t...
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Heavy ion energy influence on multiple-cell upsets in small sensitive volumes: from standard to high energies
The 28 nm process has a high cost-performance ratio and has gradually become the standard for the field of radiation-hardened devices. However, owing to the minimum physical gate length of only 35 nm, the phys...
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Open AccessCircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis
The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed in HCC cases through bioinformatics analysis. This ...
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Article
Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...
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An Effective Approach for the Preparation of High Performance Thermal Conductive Polymer Composites Containing Liquid Metal
The preparation of high-performance thermal conductive composites containing liquid metals (LM) has attracted significant attention. However, the stable dispersion of LM within polymer solution and effective p...