180 Result(s)

Article

Advancing targeted combination chemotherapy in triple negative breast cancer: nucleolin aptamer-mediated controlled drug release

Triple-negative breast cancer (TNBC) is a recurrent, heterogeneous, and invasive form of breast cancer. The treatment of TNBC patients with paclitaxel and fluorouracil in a sequential manner has shown promisin...

Yuan Ma, Duoli **e, Zefeng Chen, … in Journal of Translational Medicine (2024)

Article

Deciphering the tumor immune microenvironment from a multidimensional omics perspective: insight into next-generation CAR-T cell immunotherapy and beyond

Tumor immune microenvironment (TIME) consists of intra-tumor immunological components and plays a significant role in tumor initiation, progression, metastasis, and response to therapy. Chimeric antigen recept...

Zhaokai Zhou, Jiahui Wang, Jiaojiao Wang, Shuai Yang, Ruizhi Wang… in Molecular Cancer (2024)

Article

Assessment of subclinical LV myocardial dysfunction in T2DM patients with diabetic peripheral neuropathy: a cardiovascular magnetic resonance study

Diabetic peripheral neuropathy (DPN) is the most prevalent complication of diabetes, and has been demonstrated to be independently associated with cardiovascular events and mortality. This aim of this study wa...

Xue-Ming Li, Ke Shi, Li Jiang, **g Wang, Wei-Feng Yan… in Cardiovascular Diabetology (2024)

Article

Molecular subtypes of ischemic heart disease based on circadian rhythm

Coronary atherosclerotic heart disease (CAD) is among the most prevalent chronic diseases globally. Circadian rhythm disruption (CRD) is closely associated with the progression of various diseases. However, th...

Zhaokai Zhou, Ge Zhang, Zhan Wang, Yudi Xu, Hongzhuo Qin… in Scientific Reports (2024)

Article

Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response

Psychiatric comorbidity is common in symptom-based diagnoses like autism spectrum disorder (ASD), attention/deficit hyper-activity disorder (ADHD), and obsessive-compulsive disorder (OCD). However, these co-oc...

Shaoling Zhao, Qian Lv, Ge Zhang, Jiangtao Zhang, Heqiu Wang… in Neuroscience Bulletin (2024)

Article

Enantioselective synthesis of chiral amides by carbene insertion into amide N–H bond

Chiral amides are important structure in many natural products and pharmaceuticals, yet their efficient synthesis from simple amide feedstock remains challenge due to its weak Lewis basicity. Herein, we descri...

Xuan-Ge Zhang, Zhi-Chun Yang, Jia-Bin Pan, **ao-Hua Liu… in Nature Communications (2024)

Article

The Characteristics of the Influenza Virus Epidemic Around the SARS-CoV-2 Epidemic Period in the Pudong New Area of Shanghai

The concurrent impact of COVID-19 and influenza on disease burden is a topic of great concern. This discussion delves into the epidemiological characteristics of seasonal influenza activity in Shanghai within ...

Ge Zhang, Anran Zhang, Li Zhang, Aiqin Zhu… in Journal of Epidemiology and Global Health (2024)

Article

Physical frailty intensifies the positive association of oral frailty with poor global cognitive function and executive function among older adults especially for females: a cross-sectional study

Oral frailty is reported to increase the risk of new onset of mild cognitive impairment. Whereas, the association of oral frailty with cognition among older adults in both physical frail and non-physical frail...

Yang Fei, Shuzhen Niu, Xueru **, Wen** Tang, Yue Zhao, Ge Zhang… in BMC Geriatrics (2024)

Article

MicroRNA-451 Regulates Angiogenesis in Intracerebral Hemorrhage by Targeting Macrophage Migration Inhibitory Factor

Intracerebral hemorrhage (ICH) is a subtype of stroke with the highest fatality and disability rate. Up to now, commonly used first-line therapies have limited value in improving prognosis. Angiogenesis is ess...

Shuang Bai, Ge Zhang, Shiling Chen, Xuan Wu, Jiarui Li… in Molecular Neurobiology (2024)

Article

Glycemic control and clinical outcomes in diabetic patients with heart failure and reduced ejection fraction: insight from ventricular remodeling using cardiac MRI

Glycemic control, as measured by glycosylated hemoglobin (HbA1c), is an important biomarker to evaluate diabetes severity and is believed to be associated with heart failure development. Type 2 diabetes mellit...

Ke Shi, Ge Zhang, Hang Fu, Xue-Ming Li, Yue Gao, Rui Shi… in Cardiovascular Diabetology (2024)

Article

Responses of soil microbial community activities and soil physicochemical properties to coal fly ash soil amendment

Hundreds of millions of tons coal fly ash are produced annually to support economic development and industrial production. However, directly applying coal fly ash to agricultural production can decrease the la...

Fangze Li, Tianqi Qi, Ge Zhang, **ngjie Lin, **aohua Li… in Annals of Microbiology (2024)

Article

Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia

To investigate the efficacy of different doses of corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia.

Ge zhang, Lin Su, Wenwen Wu, Qing Qiao, Shuncui Gao, Yan Zhang… in Virology Journal (2024)

Article

The association between physical activity, self-efficacy, stress self-management and mental health among adolescents

This study aimed to explore the interplay between physical activity, self-efficacy, stress self-management and mental health among adolescents. The study gathered data from an online survey conducted among 400...

Ge Zhang, Wanxuan Feng, Liangyu Zhao, **uhan Zhao, Tuojian Li in Scientific Reports (2024)

Article

Abnormalities of retinal function in type 2 diabetes mellitus patients without clinical diabetic retinopathy detected by multifocal electroretinogram

To study the changes of retinal function in type 2 diabetes mellitus(DM) patients without apparently diabetic retinopathy via multifocal electroretinogram. Methods: Thirty-six type 2 DM patients (72 eyes) with...

Rong-Rong Li, Yang Yang, Meng-Ge Zhang, Jie Wang, Hong Chen, Shan Liu… in BMC Ophthalmology (2024)

Article

Correction to: Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages

Ying Xue, Han **ao, Songhe Guo, Banglao Xu, Yuehua Liao, Yixian Wu… in Cell Death & Disease (2024)

Article

A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis

The common human SNP rs3820282 is associated with multiple phenotypes including gestational length and likelihood of endometriosis and cancer, presenting a paradigmatic pleiotropic variant. Deleterious pleiotr...

Mihaela Pavličev, Caitlin E. McDonough-Goldstein… in Nature Communications (2024)

Article

Reduced thoracic skeletal muscle size is associated with adverse outcomes in diabetes patients with heart failure and reduced ejection fraction: quantitative analysis of sarcopenia by using cardiac MRI

Sarcopenia is frequently found in patients with heart failure with reduced ejection fraction (HFrEF) and is associated with reduced exercise capacity, poor quality of life and adverse outcomes. Recent evidence...

Ke Shi, Ge Zhang, Hang Fu, Xue-Ming Li, Shi-Qin Yu, Rui Shi… in Cardiovascular Diabetology (2024)

Article

Uncovering impaired mitochondrial and lysosomal function in adipose-derived stem cells from obese individuals with altered biological activity

Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those ...

Bo Wang, Ge Zhang, Yuwen Hu, Ali Mohsin, Zhimin Chen… in Stem Cell Research & Therapy (2024)

Article

The Role of ICP Monitoring in Minimally Invasive Surgery for the Management of Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is the second major stroke type, with high incidence, high disability rate, and high mortality. At present, there is no effective and reliable treatment for ICH. As a result, mos...

Ge Zhang, Yunjie Li, Danyang Chen, Zhuo** Wu, Chao Pan… in Translational Stroke Research (2023)

Article

Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer

Ferroptosis is a new type of iron-dependent programmed cell death induced by lipid peroxidation. However, the underlying mechanisms and function in tumor therapy still remain undisclosed especially in post-tra...

Ge Zhang, Wunan Mi, Chuyue Wang, Jiehan Li, Yizheng Zhang… in Cell Death Discovery (2023)