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Life Sciences
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Article
Open AccessLRIG1 controls proliferation of adult neural stem cells by facilitating TGFβ and BMP signalling pathways
Adult Neural Stem Cells (aNSCs) in the ventricular-subventricular zone (V-SVZ) are largely quiescent. Here, we characterize the mechanism underlying the functional role of a cell-signalling inhibitory protein,...
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Open AccessDecoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing
Dysfunction or deficiency of corneal epithelium results in vision impairment or blindness in severe cases. The rapid and effective regeneration of corneal epithelial cells relies on the limbal stem cells (LSCs...
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Mitigation of Desulfovibrio ferrophilus IS5 degradation of X80 carbon steel mechanical properties using a green biocide
Most microbiologically influenced corrosion (MIC) studies focus on the threat of pinhole leaks caused by MIC pitting. However, microbes can also lead to structural failures. Tetrakis hydroxymethyl phosphonium ...
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Open AccessPUB40 attenuates Phytophthora capsici resistance by destabilizing the MEK2-SIPK/WIPK cascade in Nicotiana benthamiana
The mitogen-activated protein kinase (MAPK) cascade MEK2-SIPK/WIPK is essential for immunity in Solanaceae plants. This cascade is tightly controlled to prevent harmful hyperactivation. However, the E3 ubiquit...
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Open AccessControl of coptis root rot by combination of Bacillus cereus isolate Y9 and other antagonistic microorganisms
Root rot is a destructive soil-borne disease of Coptis chinensis, which depends on chemical control at present, and more attention should be paid to biocontrol of disease. In the present research, isolate Y9 isol...
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Open AccessReciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer
Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activat...
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Open AccessInhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury
Obstructive sleep apnea (OSA) can lead to intestinal injury, endotoxemia, and disturbance of intestinal flora. Additionally, as a crucial component of the endocannabinoid system, some studies have demonstrated...
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Open AccessGreen or grain? Impact of green space expansion on grain production in Chinese cities and its implications for national urban greening schemes
Expansion of urban green space (UGS) enhances greenery and its benefits in cities. However, the impacts of such expansions on regional landscape sustainability and their spatiotemporal traits across the nation...
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Mendelian randomization evidence for the causal effect of mental well-being on healthy aging
Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and...
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Open AccessDDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease
The loss of dopaminergic neurons in the substantia nigra is a hallmark of pathology in Parkinson’s disease (PD). Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is the critical enzyme responsible for the de...
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Open AccessAuthor Correction: PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
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SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Mu...
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Culture of cerebrospinal fluid-contacting neurons from neonatal mouse spinal cord
Cerebrospinal fluid-contacting neurons (CSF-cNs) act crucial role in chemosensory and mechanosensory function in spinal cord. Recently, CSF-cNs were found to be an immature neuron and may be involved in spinal...
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Differences among active toluene-degrading microbial communities in farmland soils with different levels of heavy metal pollution
Heavy metals can severely influence the mineralisation of organic pollutants in a compound-polluted environment. However, to date, no study has focused on the effects of heavy metals on the active organic poll...
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Hormonal regulation changes in shrimp infected with Enterocytozoon hepatopenaei: a transcriptomic analysis
Enterocytozoon hepatopenaei (EHP) is a fungal pathogen that causes hepatopancreatic microsporidiosis (HPM) in shrimp, resulting in significant economic losses for the shrimp culture industry. Although the impact...
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Open AccessComparative chloroplast-specific SNP and nSCoT markers analysis and population structure study in kiwifruit plants
Kiwifruit (Actinidiaceae family) is an economically important fruit tree in China and New Zealand. It is a typical dioecious plant that has undergone frequent natural hybridization, along with chromosomal ploi...
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Open AccessThe effect of lipid-lowering therapy on lipid-related residual risk factors: a prospective study
Remnant cholesterol (RC) and nonhigh-density lipoprotein cholesterol (nonHDL-C) are key risk factors for atherosclerotic cardiovascular disease (ASCVD), with apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)] ...
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The Effects of Zinc Oxide Nanoparticles on Antioxidation, Inflammation, Tight Junction Integrity, and Apoptosis in Heat-Stressed Bovine Intestinal Epithelial Cells In Vitro
Zinc oxide nanoparticles (nano-ZnO) have diverse applications in numerous biomedical processes. The present study explored the effects of these nanoparticles on antioxidation, inflammation, tight junction inte...
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Open AccessAuthor Correction: PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
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Article
Dynamic simulation of photosynthate distribution parameters and biomass of summer maize under water stress
Water shortages and population surges pose notable challenges to food security. North China is an important grain base of the country, with limited available water resources. Therefore, it is necessary to rese...
