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Article
Dual roles of progesterone in embryo implantation in mouse
Progesterone (P4) is essential for the development of endometrial receptivity for blastocyst implantation and pregnancy maintenance. Many studies have demonstrated that P4 restrains endometrial tissue breakdown b...
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Article
Models of glycoprotein hormone receptor interaction
The glycoprotein hormones regulate reproduction and development through their interactions with receptors in ovarian, testicular, and thyroid tissues. Efforts to design hormone agonists and antagonists useful ...
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Article
Sex-specific effects of androgen and estrogen on proliferation of the embryonic chicken hypothalamic neurons
Effects of androgen and estrogen on proliferation of hypothalamic neurons were evaluated by a chicken hypothalamic neuron-glia coculture model. Hypothalamic cells were dispersed from 17-day-old embryos and cha...
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Article
Lack of association between interleukin-1a gene (IL-1a) C (-889) T variant and polycystic ovary syndrome in chinese women
Polycystic ovary syndrome (PCOS) is associated with the spontaneous development of an aberrant heterogeneous hormonal environment that thought to be related to multiple genetic or environmental factors remain ...
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Article
Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic ovary syndrome in Chinese
Polycystic ovary syndrome (PCOS) is a complex multi-factorial disorder involving a number of genetic and environmental factors. CYP1A1 (Cytochrome P450, family 1, subfamily A, polypeptide 1) gene, which belongs t...
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Article
FABP4: a novel candidate gene for polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder involving a number of genetic and environmental factors. Adipocyte-fatty acid-binding protein (FABP4) is an adipokine regulating systemic i...
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Article
Differential expression of gonadotropin-releasing hormone (GnRH) in pancreas during rat pregnancy
Many studies have shown that there is a relationship between gonadotropin-releasing hormone (GnRH) and glucose metabolism, but little is known about the effects of GnRH on the pancreas. Our experiment investig...
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Article
Interleukin 1 beta (IL-1β) promoter C [−511] T polymorphism but not C [+3953] T polymorphism is associated with polycystic ovary syndrome
PCOS is a complex multifactorial disorder involving a number of genetic and environmental factors. One of the genetic factors that has been associated with PCOS is Interleukin 1 beta (IL-1β), is an important i...
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Article
A polymorphism near osteoprotegerin gene confer risk of obesity in Uyghurs
To investigate the association of single nucleotide polymorphism (SNP) rs4355801 near osteoprotegerin (OPG) gene and rs3736228 in low-density lipoprotein receptor-related protein 5 (LRP5) gene with metabolic p...
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Article
Adiponectin protects endothelial cells from the damages induced by the intermittent high level of glucose
Globular adiponectin (gAd) has anti-atherogenic effects on the vascular wall. Intermittent hyperglycemia induces endothelial cells (ECs) injury but the physiological factors that may protect against ECs damage...
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Article
Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case–control study of Chinese Han population
This study was to evaluate the association between ADIPOQ gene variants and type 2 diabetes mellitus (T2DM). TaqMan® assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal control subje...
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Article
Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development
We aim to investigate the preventive and therapeutic effects of ghrelin on a rat NAFLD model and possible underlying mechanism. Sprague–Dawley rats were fed with high-fat diet for 8 weeks to induce NAFLD. A gr...
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Article
The effects of sulfonylureas plus metformin on lipids, blood pressure, and adverse events in type 2 diabetes: a meta-analysis of randomized controlled trials
To compare the effects of sulfonylureas and metformin versus metformin on lipid profiles, blood pressure, and adverse events. PubMed, EMbase, Chinese BioMedical Literature on disc, China National Knowledge Inf...
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Article
Ultrasound-guided fine-needle aspiration for solid thyroid nodules larger than 10 mm: correlation between sonographic characteristics at the needle tip and nondiagnostic results
The objective of this study was to investigate the effect of the ultrasonographic (US) characteristics and ultrasound elastography (UE) patterns on the probability of a nondiagnostic result when performing ult...
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Article
Effects of dihydrotestosterone on adhesion and proliferation via PI3-K/Akt signaling in endothelial progenitor cells
The protective effects of male hormones on the cardiovascular system are still in dispute. There is now ample evidence that testosterone level is negatively correlated to the incidence and mortality of cardiov...
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Article
Association between calcaneus quantitative ultrasound (QUS) parameters and thyroid status in middle-aged and elderly Chinese men with euthyroidism: a population-based cross-sectional study
Although it is generally accepted that thyroid hormones affect bone metabolism, there is little data on the association of thyroid antibodies with bone status. We aimed to investigate the association between ...
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Article
Meta-analysis of the association of ADIPOQ G276T polymorphism with insulin resistance and blood glucose
Insulin resistance (IR) is a major risk for the development of type 2 diabetes (T2D). Numerous studies have been conducted to determine the relationship of ADIPOQ G276T with IR and blood glucose, but the results...
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Article
Should we still be concerned about the potential side effects of glucagon-like peptide-1 receptor agonists on thyroid C cells?
In recent years, numerous novel anti-diabetic drugs have emerged. Among them, glucagon-like peptide-1 receptor (GLP-1R) agonists developed on the basis of the incretin theory are the most popular and surprisin...
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Article
A novel function for fibroblast growth factor 21: stimulation of NADPH oxidase-dependent ROS generation
Fibroblast growth factor 21 (FGF-21) is a major paracrine and endocrine regulator of metabolic homeostasis. Here we demonstrate that FGF-21 is also a potent mediator of innate immunity. Double-staining flow cy...
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Article
USP8: a novel therapeutic target for Cushing’s disease
Cushing’s disease (CD), caused by an adrenocorticotropin-secreting pituitary adenoma, leads to hypercortisolemia and causes serious morbidity and increased mortality when suboptimally treated. Currently, the g...