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Article
Efficient molecular conformation generation with quantum-inspired algorithm
Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown g...
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Article
A high-density 1,024-channel probe for brain-wide recordings in non-human primates
Large-scale neural population recordings with single-cell resolution across the primate brain remain challenging. Here we introduce the Neuroscroll probe that isolates single neuronal activities simultaneously...
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Article
Open AccessRapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological processes. In vitro reconstitution of ubiquitinated nucleosomes is pivotal for elucidating t...
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Article
Correction: Roles of estrogen receptors during sexual reversal in pelodiscus sinensis
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Open AccessCorrection to: Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury
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Open AccessPyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation
The endogenous mitochondrial quality control (MQC) system serves to protect mitochondria against cellular stressors. Although mitochondrial dysfunction contributes to cardiac damage during many pathological co...
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Article
Open AccessMolecular epidemiological and clinical infection characteristics analysis of Ralstonia
This study was to clarify the molecular epidemiology and clinical infection characteristics of Ralstonia pickettii and establish sequence ty** system.
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Open AccessXylem adjustment and growth response of early- and late-successional tree species to rapid warming
Climate changes have dramatically affected forest succession. However, how trees at different successional stages respond to climate warming is unclear in the subtropics. Here, we compared the radial growth (R...
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Open AccessNur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy
The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether Nur77 inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not...
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Open AccessOld Pinus massoniana forests benefit more from recent rapid warming in humid subtropical areas of central-southern China
Trees progress through various growth stages, each marked by specific responses and adaptation strategies to environmental conditions. Despite the importance of age-related growth responses on overall forest h...
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Roles of estrogen receptors during sexual reversal in Pelodiscus sinensis
The Chinese soft-shelled turtle, Pelodiscus sinensis, exhibits distinct sexual dimorphism, with the males growing faster and larger than the females. During breeding, all-male offspring can be obtained using 17β-...
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Article
Effect of Zr/Ti Ratio on the Structure and Electrical Properties of 0.7PbZrxTi1−xO3-0.3Pb(Zn1/3Nb2/3)O3 Piezoelectric Ceramics
Ternary system piezoelectric ceramics 0.7PbZrxTi1−xO3-0.3Pb(Zn1/3Nb2/3)O3 (abbreviated as 0.7PZTx-0.3PZN) were prepared by a traditional solid-phase process. With the increase in Zr content, the electrical proper...
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Article
A double Actor-Critic learning system embedding improved Monte Carlo tree search
As the bias between the estimated value and the true value, overestimation is a basic problem in reinforcement learning, which leads to a lower total reward because of the incorrect action decisions. In order ...
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Article
Electroplating sludge-derived magnetic copper-containing catalysts for selective hydrogenation of bio-based furfural
A series of inexpensive electroplating sludge-derived magnetic copper-containing catalysts were developed for the selective hydrogenation of biomass-based furfural (FFR) into furfuryl alcohol (FA) and 2-methyl...
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Long-term changes in radial growth of seven tree species in the mixed broadleaf-Korean pine forest in Northeast China: Are deciduous trees favored by climate change?
The role of the temperate mixed broadleaf-Korean pine forest (BKF) in global biogeochemical cycles will depend on how the tree species community responds to climate; however, species-specific responses and vul...
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Article
Innovation and Firm Co-ownership Network in China’s Electric Vehicle Industry
Firms are embedded in complex networks, where diverse ideas combine and generate new ideas. Shareholders of firms are often seen as critical external resources that have significant influence on firm innovatio...
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Article
Face-to-face contact and university–industry collaboration: evidence from mobile signaling data in Bei**g
The university–industry collaboration is an essential engine of the regional innovation system and can significantly drive regional economic growth. The realization of intellectual collaboration, especially fo...
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Performance evaluation of rhamnolipid biosurfactant produced by Pseudomonas aeruginosa and its effect on marine oil-spill remediation
This study aimed to reveal that the effect of biosurfactant on the dispersion and degradation of crude oil. Whole genome analysis showed that Pseudomonas aeruginosa GB-3 contained abundant genes involved in biosu...
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Open AccessLanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo
Nanothermometers enable the detection of temperature changes at the microscopic scale, which is crucial for elucidating biological mechanisms and guiding treatment strategies. However, temperature monitoring o...
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Article
Open AccessDeep learning-based automated lesion segmentation on pediatric focal cortical dysplasia II preoperative MRI: a reliable approach
Focal cortical dysplasia (FCD) represents one of the most common causes of refractory epilepsy in children. Deep learning demonstrates great power in tissue discrimination by analyzing MRI data. A prediction m...
