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  1. Article

    Open Access

    Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy

    The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether Nur77 inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not...

    Huanying Shi, Lu Chen, Tianxiao Wang, Wenxin Zhang, Jiafeng Liu… in Cell Death Discovery (2024)

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  2. Article

    Open Access

    Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer

    The efficacy of anti-PD-1 therapy is primarily hindered by the limited T-cell immune response rate and immune evasion capacity of tumor cells. Autophagy-related protein 7 (ATG7) plays an important role in auto...

    Wenxin Zhang, Lu Chen, Jiafeng Liu… in Journal of Experimental & Clinical Cancer … (2024)

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  3. No Access

    Article

    FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models

    FTY720 (fingolimod) is the first oral drug approved for treating relapsing-remitting forms of multiple sclerosis. It is also protective in other neurological models including ischemia, Alzheimer’s disease, Hun...

    Manru Ren, Minxing Han, **nbing Wei, Ying Guo, Huanying Shi… in Neurochemical Research (2017)

  4. No Access

    Article

    Eriodictyol Attenuates β-Amyloid 25–35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2

    Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). Eriodictyol, a flavonoid isolated from the Chinese herb Dracocephalum rupestre, has ...

    Xu **g, Huanying Shi, **uying Zhu, **nbing Wei, Manru Ren… in Neurochemical Research (2015)

  5. No Access

    Article

    (−)-Epigallocatechin Gallate Protects Against Cerebral Ischemia-Induced Oxidative Stress via Nrf2/ARE Signaling

    (−)-Epigallocatechin gallate (EGCG) has recently been shown to exert neuroprotection in a variety of neurological diseases; however, its role and the underlying mechanisms in cerebral ischemic injury are not f...

    Jie Han, Miaomiao Wang, Xu **g, Huanying Shi, Manru Ren… in Neurochemical Research (2014)