15 Result(s)

Article

Personal characteristics related to the risk of adolescent internet addiction: a survey in Shanghai, China

Paralleling the rapid growth in computers and internet connections, adolescent internet addiction (AIA) is becoming an increasingly serious problem, especially in develo** countries. This study aims to explo...

Jian Xu, Li-xiao Shen, Chong-huai Yan, Howard Hu, Fang Yang, Lu Wang… in BMC Public Health (2012)

Article

Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015

A1 Hope and despair in the current treatment of nasopharyngeal cancer

IB Tan, Ellen T. Chang, Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien… in BMC Proceedings (2016)

Article

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the A...

Jun Wang, Bin-Lu Sun, Yang **ang, Ding-Yuan Tian, Chi Zhu… in Translational Psychiatry (2020)

Article

C/EBPβ promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer

PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, they exhibit suboptimal efficiency in HR-proficient cancers...

Jiahong Tan, Xu Zheng, Mengchen Li, Fei Ye, Chunyan Song, Cheng Xu… in Oncogene (2021)

Article

Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interv...

**aofen Ruan, Yi** Li, Yuanlong Sun, Meijun Jia, **aowen Xu, Li Huo, Wei Song… in Trials (2021)

Article

Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

ASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually heterozygous frameshift or nonsense mutations leading to C-termi...

**ao Fang, Song’en Xu, Yiyue Zhang, ** Xu, Zhibin Huang, Wei Liu… in Leukemia (2021)

Article

Single VHH-directed BCMA CAR-T cells cause remission of relapsed/refractory multiple myeloma

Lu Han, Ji-Shuai Zhang, Jian Zhou, Ke-Shu Zhou, Ben-Ling Xu, Lin-Lin Li… in Leukemia (2021)

Article

Disrupted intrinsic functional brain topology in patients with major depressive disorder

Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, w...

Hong Yang, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Molecular Psychiatry (2021)

Article

Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...

Yu-Dan Ding, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Translational Psychiatry (2022)

Article

Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype

Lung adenocarcinoma (LUAD) exhibits high heterogeneity and is well known for its high genetic variation. Recently, the understanding of non-genetic variation provides a new perspective to study the heterogenei...

Xuming Song, Te Zhang, Hanlin Ding, Yipeng Feng, Wenmin Yang, Xuewen Yin… in Oncogenesis (2022)

Article

Spatiotemporal trends and ecological determinants of cardiovascular mortality among 2844 counties in mainland China, 2006–2020: a Bayesian modeling study of national mortality registries

Cardiovascular disease (CVD) is the leading cause of death in China. No previous study has reported CVD mortality at county-level, and little was known about the nonmedical ecological factors of CVD mortality ...

Wei Wang, Junming Li, Yunning Liu, Pengpeng Ye, Chengdong Xu, Peng Yin… in BMC Medicine (2022)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

Research on obesity- and diabetes mellitus (DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as important risk factors for cancers. The growing interest in this ar...

Rexiati Ruze, Jianlu Song, **npeng Yin… in Signal Transduction and Targeted Therapy (2023)

Article

Status quo of the public’s knowledge of probiotics based on video-sharing platforms

Probiotics have been deemed multipotent and unprecedentedly applied in the health field recently. However, there are challenges in promoting credible and reliable resources while avoiding misinformation regard...

Chun-Hui Jiang, Jia-Jia Xu, Chao Xu, Shi-Yue Chen, Jia-Yun Chen… in BMC Public Health (2023)

Article

AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved trea...

Iris Wu, Aliya Zeng, Amara Greer-Short, J. Alex Aycinena… in Communications Medicine (2024)