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  1. No Access

    Article

    STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion

    Acute lung injury (ALI) is a common and devastating clinical disorder featured by excessive inflammatory responses. Stimulator of interferon genes (STING) is an indispensable molecule for regulating inflammati...

    Bing Wu, Meng-meng Xu, Chen Fan, Chun-lan Feng, Qiu-kai Lu… in Acta Pharmacologica Sinica (2022)

  2. Article

    2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

    Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,...

    ** Zhang, Li-na Zhang, Dong-mei Chen, Yan-yun Fu, Feng Zhang… in Acta Pharmacologica Sinica (2015)

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  3. Article

    Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation

    To investigate the action of isothiafludine (NZ-4), a derivative of bis-heterocycle tandem pairs from the natural product leucamide A, on the replication cycle of hepatitis B virus (HBV) in vitro and in vivo.

    Li Yang, Li-** Shi, Hai-jun Chen, **an-Kun Tong… in Acta Pharmacologica Sinica (2014)

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  4. Article

    Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy

    To investigate the drug interactions between ilaprazole, a new proton pump inhibitor, and clarithromycin following ilaprazole, clarithromycin and amoxicillin combination therapy.

    Shan Cao, Gan Zhou, Dong-sheng Ou-YANG, Hui-zi Wu, Kui **ao… in Acta Pharmacologica Sinica (2012)

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  5. No Access

    Article

    Immunologic Analysis of HIV-Uninfected Taiwanese Children with BCG-Induced Disease

    The aim of this study was to evaluate immunity in HIV-uninfected children with bacille Calmette–Guerin-induced disease (BCG-ID) over an 8-year period, with particular emphasis on underlying diseases.

    Wen-I Lee, Fang-Chen Liang, **g-Long Huang… in Journal of Clinical Immunology (2009)

  6. Article

    Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes

    To characterize the molecular mechanisms of nitrofen-induced pulmonary hypoplasia.

    Qiang-song Tong, Li-duan Zheng, Shao-tao Tang, Guo-song Jiang… in Acta Pharmacologica Sinica (2007)

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