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  1. Article

    Open Access

    Real-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan

    Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is commit...

    Chun-Chi Yang, Chung-Feng Huang, Te-Sheng Chang in Infectious Diseases and Therapy (2024)

  2. Article

    Open Access

    The risk factors of the 72-h unscheduled return visit admission to emergency department in adults below 50 years old

    An unscheduled return visit (URV) to the emergency department (ED) within 72-h is an indicator of ED performance. An unscheduled return revisit (URV) within 72-h was used to monitor adverse events and medical ...

    Chia-Lung Kao, Chia-Chang Chuang, Chi-Yuan Hwang in European Journal of Medical Research (2023)

  3. Article

    Open Access

    Predictive models for short-term mortality and length of hospital stay among adults with community-onset bacteraemia before and during the COVID-19 pandemic: application of early data dynamics

    The development of scoring systems to predict the short-term mortality and the length of hospital stay (LOS) in patients with bacteraemia is essential to improve the quality of care and reduce the occupancy va...

    Ching-Chi Lee, Yuan-Pin Hung, Chih-Chia Hsieh, Ching-Yu Ho in BMC Infectious Diseases (2023)

  4. Article

    Open Access

    Near-infrared cholangiography can increase the chance of success in laparoscopic approaches to common bile duct stones, even with previous abdominal surgery

    The treatment of common bile duct (CBD) stones with minimally invasive surgery (MIS) is more technical demanding than laparoscopic cholecystectomy (LC), especially in patients with history of previous abdomina...

    Wei-Juo Tzeng, Yu-Hung Lin, Teng-Yuan Hou, Shih‑Min Yin, Yu-Cheng Lin in BMC Surgery (2023)

  5. Article

    Open Access

    Prognostic value of computed tomographic findings in acute respiratory distress syndrome and the response to prone positioning

    Prone positioning enables the redistribution of lung weight, leading to the improvement of gas exchange and respiratory mechanics. We aimed to evaluate whether the initial findings of acute respiratory distres...

    You-Yi Chen, Jerry Shu-Hung Kuo, Sheng-Yuan Ruan, Ying-Chun Chien in BMC Pulmonary Medicine (2022)

  6. Article

    Open Access

    Sofosbuvir/Velpatasvir for Hepatitis C Virus Infection: Real-World Effectiveness and Safety from a Nationwide Registry in Taiwan

    Pangenotypic direct-acting antivirals are expected to cure hepatitis C virus (HCV) in more than 95% of treated patients. However, data on the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) in Tai...

    Pin-Nan Cheng, Lein-Ray Mo, Chun-Ting Chen, Chi-Yi Chen in Infectious Diseases and Therapy (2022)

  7. Article

    Open Access

    Suppressor of variegation 3–9 homologue 1 impairment and neutrophil-skewed systemic inflammation are associated with comorbidities in COPD

    Systemic manifestations and comorbidities are characteristics of chronic obstructive pulmonary disease (COPD) and are probably due to systemic inflammation. The histone methyltransferase SUV39H1 controls the T...

    Tzu-Tao Chen, Sheng-Ming Wu, Kuan-Yuan Chen, Chien-Hua Tseng in BMC Pulmonary Medicine (2021)

  8. Article

    Open Access

    Etiology-associated heterogeneity in acute respiratory distress syndrome: a retrospective cohort study

    Heterogeneity in acute respiratory distress syndrome (ARDS) has led to many statistically negative clinical trials. Etiology is considered an important source of pathogenesis heterogeneity in ARDS but previous...

    Sheng-Yuan Ruan, Chun-Ta Huang, Ying-Chun Chien, Chun-Kai Huang in BMC Pulmonary Medicine (2021)

  9. Article

    Open Access

    Severe, but not mild to moderate, non-alcoholic fatty liver disease associated with increased risk of subclinical coronary atherosclerosis

    Non-alcoholic fatty liver disease (NAFLD) is associated with high risk of cardiovascular disease. The prevalence is increasing to 45–65% in the general population with routine health check-up, and most subject...

    Chia-Chi Hsiao, Pai-Hsueh Teng, Yun-Ju Wu, Yi-Wen Shen in BMC Cardiovascular Disorders (2021)

  10. Article

    Open Access

    MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner

    MRE11, the nuclease component of RAD50/MRE11/NBS1 DNA repair complex which is essential for repair of DNA double-strand-breaks in normal cells, has recently garnered attention as a critical factor in solid tum...

    Yen-Yun Wang, Yuk-Kwan Chen, Steven Lo, Tsung-Chen Chi, Yi-Hua Chen in Oncogene (2021)

  11. Article

    Open Access

    Natural course of coronary artery calcium progression in Asian population with an initial score of zero

    We aimed to investigate the natural course of coronary artery calcium progression in an Asian population with a baseline coronary artery calcium (CAC) score of zero, and to determine subclinical coronary ather...

    Yi-Wen Shen, Yun-Ju Wu, Yi-Chi Hung, Chia-Chi Hsiao in BMC Cardiovascular Disorders (2020)

  12. Article

    Open Access

    Litchi seed extract inhibits epidermal growth factor receptor signaling and growth of Two Non-small cell lung carcinoma cells

    Litchi seeds possess rich amounts of phenolics and have been shown to inhibit proliferation of several types of cancer cells. However, the suppression of EGFR signaling in non-small cell lung cancer (NSCLC) by...

    Yuan-Chiang Chung, Chin-Hui Chen in BMC Complementary and Alternative Medicine (2017)

  13. No Access

    Article

    Improved outcomes of colorectal cancer patients with liver metastases in the era of the multidisciplinary teams

    The use of multidisciplinary teams (MDTs), which address colorectal cancer treatment planning through weekly regular group meetings, was begun in October 2007. We analyzed and compared the outcomes of colorect...

    Yuan-Tzu Lan, Jeng-Kai Jiang in International Journal of Colorectal Disease (2016)

  14. Article

    Open Access

    The use of corticosteroids in patients with COPD or asthma does not decrease lung squamous cell carcinoma

    Asthma and COPD (chronic obstructive pulmonary disease) lead to persistent airway inflammation and are associated with lung cancer. The objective of the study was to assess the relationship between inhaled (IC...

    Zhi-Hong Jian, **g-Yang Huang, Frank Cheau-Feng Lin in BMC Pulmonary Medicine (2015)

  15. Article

    Open Access

    Integrating team resource management program into staff training improves staff’s perception and patient safety in organ procurement and transplantation: the experience in a university-affiliated medical center in Taiwan

    The process involved in organ procurement and transplantation is very complex that requires multidisciplinary coordination and teamwork. To prevent error during the processes, teamwork education and training m...

    Ya-Chi Hsu, Jih-Shuin Jerng, Ching-Wen Chang, Li-Chin Chen, Ming-Yuan Hsieh in BMC Surgery (2014)

  16. Article

    Open Access

    Antidepressant-like activity of turmerone in behavioral despair tests in mice

    The present study was undertaken to evaluate the anti-depressive activity of turmerone after one-week administration by using a mouse forced swimming test (FST) and tail suspension test (TST).

    Jung-Chun Liao, Jen-Chieh Tsai, Chia-Yu Liu in BMC Complementary and Alternative Medicine (2013)

  17. No Access

    Article

    Reliable categorisation of visual scoring of coronary artery calcification on low-dose CT for lung cancer screening: validation with the standard Agatston score

    To validate the reliability of the visual coronary artery calcification score (VCACS) on low-dose CT (LDCT) for concurrent screening of CAC and lung cancer.

    Yi-Luan Huang, Fu-Zong Wu, Yen-Chi Wang, Yu-Jeng Ju, Guang-Yuan Mar in European Radiology (2013)

  18. No Access

    Article

    Pulmonary embolism after tadalafil ingestion

    Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor that is used to treat male erectile dysfunction. It is currently undergoing clinical trials for the treatment of pulmonary hypertension. Although at present ...

    Huang-Chi Chen, Chuan-Sheng Wang, Shu-Hui Chuang in Pharmacy World & Science (2008)

  19. No Access

    Article

    Marked thrombocytosis during treatment with ceftazidime for pulmonary infection

    When an infected patient suffers from thrombocytosis, it is very difficult to identify beta-lactam antibiotic induced cases of the disease and separate these from the possibility that the disease is an acute-p...

    Huang-Chi Chen, Cheng-Yuan Wang, Chuan-Sheng Wang in Pharmacy World & Science (2008)