27 Result(s)

Article

Correction: Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease

Yan-fang Hou, Chang Shan, Si-yue Zhuang, Qian-qian Zhuang, Arijit Ghosh… in Microbiome (2024)

Article

Idebenone Antagonizes P53-Mediated Neuronal Oxidative Stress Injury by Regulating CD38-SIRT3 Protein Level

Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD...

Hao Xu, Ying Guo, **ao-Jun Liu, Ying Liu, Shi Yin, Qi-Ying Bao… in Neurochemical Research (2024)

Article

Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...

**u-chun Li, **a-yan Zhu, Yang-yue Wang, Shuo-lan Tong… in Acta Pharmacologica Sinica (2024)

Article

Association between irritable bowel syndrome and Parkinson’s disease by Cohort study and Mendelian randomization analysis

This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson’s disease (PD) utilizing prospective cohort study and Mendelian randomization. The dataset contained a subst...

Zhi-yun Wang, Dong-rui Ma, Meng-jie Li, Yuan-yuan Liang… in npj Parkinson's Disease (2024)

Article

Monitoring trends in the absolute lymphocyte count and the neutrophil-to-lymphocyte ratio in patients with breast cancer receiving eribulin

Studies have shown that the absolute lymphocyte count (ALC) and the neutrophil-to-lymphocyte ratio (NLR) are related to the outcomes in patients with breast cancer receiving specific chemotherapies. However, t...

Meng-**a Su, Hsiang-Wen Lin, Hanh T. H. Nguyen, Tien-Chao Lin, Chih-Jung Chen… in BMC Cancer (2024)

Article

Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2

The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, of...

Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu… in BMC Cancer (2023)

Article

Construction and validation of a nomogram to predict the overall survival of small cell lung cancer: a multicenter retrospective study in Shandong province, China

Patients diagnosed with small cell lung cancer (SCLC) typically experience a poor prognosis, and it is essential to predict overall survival (OS) and stratify patients based on distinct prognostic risks.

Ziqian Song, Hengmin Ma, Hao Sun, Qiuxia Li, Yan Liu, **g **e, Yukun Feng… in BMC Cancer (2023)

Article

The effects of the prognostic biomarker SAAL1 on cancer growth and its association with the immune microenvironment in lung adenocarcinoma

Inhibition of Serum Amyloid A-like 1 (SAAL1) expression could inhibit cancer progression and improve the prognosis of cancer patients. At present, the correlation between SAAL1 and lung adenocarcinoma (LAC) re...

Song Tong, Ni Jiang, Jun-Hao Wan, Chong-Rui Chen, Si-Hua Wang, Chuang-Yan Wu… in BMC Cancer (2023)

Article

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice

The wide spread of coronavirus disease 2019 (COVID-19) has significantly threatened public health. Human herd immunity induced by vaccination is essential to fight the epidemic. Therefore, highly immunogenic a...

Zhuo-xin Li, Sheng Feng, He Zhang, **n-yu Zhuang, Chao Shang… in Archives of Virology (2022)

Article

CD206⁺CD68⁺ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis

Antineutrophil Cytoplasmic Antibodies (ANCA) associated glomerulonephritis (AGN) is a group of autoimmune diseases and mono-macrophages are involved in its glomerular injuries. In this study, we aim to investi...

**ao-Ning An, Zhao-Nan Wei, Yin-Yin **e, **g Xu, Yan Shen, Li-Yan Ni… in BMC Immunology (2022)

Article

Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury

Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in p...

Fei Yao, Yang Luo, Yan-Chang Liu, Yi-Hao Chen, Yi-Teng Li… in Inflammation and Regeneration (2022)

Article

Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived fr...

Yan-fang Hou, Chang Shan, Si-yue Zhuang, Qian-qian Zhuang, Arijit Ghosh… in Microbiome (2021)

Article

Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study

Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be eva...

Shao-rui Hao, Ren Yan, Shan-yan Zhang… in Journal of Zhejiang University-SCIENCE B (2020)

Article

Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure

A novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan, China, has been rapidly spreading around the world. This study investigates the epidemiologic...

Jiang-shan Lian, Huan Cai, Shao-rui Hao, ** **… in Journal of Zhejiang University-SCIENCE B (2020)

Article

Correction to: The polymorphism and geographical distribution of knockdown resistance of adult Anopheles sinensis populations in eastern China

Please be advised that since publication of the original article [1] the authors have flagged that they omitted to provide the up-to-date version of Fig. 1 and, as such, the wrong version of Fig. 1 is present ...

Wei-Long Tan, Chun-**ao Li, Rui-Chen Lv, Yan-De Dong, **ao-**a Guo… in Malaria Journal (2019)

Article

The polymorphism and geographical distribution of knockdown resistance of adult Anopheles sinensis populations in eastern China

Anopheles sinensis is one of the major malaria vectors in China and other southeast Asian countries, including Vietnam, Cambodia, Thailand. Vector control is considered to be the critical measure for malaria cont...

Wei-Long Tan, Chun-**ao Li, Rui-Chen Lv, Yan-De Dong, **ao-**a Guo… in Malaria Journal (2019)

Article

EGb761 improves the cognitive function of elderly db/db^−/− diabetic mice by regulating the beclin-1 and NF-κB signaling pathways

To assess whether EGb761 could protect elderly diabetic mice with cognitive disorders and explore the role of beclin-1-mediated autophagy in these protective effects. Two-month-old male db/db^−/− mice and wild-typ...

Zhu-Fei Guan, **ao-Ming Zhang, Ying-Hong Tao, Yu Zhang… in Metabolic Brain Disease (2018)

Article

Time-dependent pharmacokinetics of dexamethasone and its efficacy in human breast cancer xenograft mice: a semi-mechanism-based pharmacokinetic/pharmacodynamic model

Dexamethasone (DEX) is the substrate of CYP3A. However, the activity of CYP3A could be induced by DEX when DEX was persistently administered, resulting in auto-induction and time-dependent pharmacokinetics (ph...

Jian Li, Rong Chen, Qing-yu Yao, Sheng-jun Liu, **u-yun Tian… in Acta Pharmacologica Sinica (2018)

Article

Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway

Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. We previously demonstrated that pretreatment with Xyl-B exerted neuroprotective effects and attenuated hypoxic-ischemic ...

Ni Pan, Liu-yi Lu, Mei Li, Guo-hao Wang, Fang-yun Sun… in Acta Pharmacologica Sinica (2017)

Article

Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL

As one of the major treatment obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph⁺ALL), relapse of Ph⁺ALL may result from the persistence of leukemia-propagating cells (LPCs). Research ...

Yuan Kong, Yi-Lin Wu, Yang Song, Min-Min Shi… in Journal of Translational Medicine (2017)