204 Result(s)

Article

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration

Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and ...

Fenglian He, Zhongen Wu, Chenglong Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Deep learning to assess microsatellite instability directly from histopathological whole slide images in endometrial cancer

Molecular classification, particularly microsatellite instability-high (MSI-H), has gained attention for immunotherapy in endometrial cancer (EC). MSI-H is associated with DNA mismatch repair defects and is a ...

Ching-Wei Wang, Hikam Muzakky, Nabila Puspita Firdi, Tzu-Chien Liu… in npj Digital Medicine (2024)

Article

Preoperative chemoradiotherapy in older patients with rectal cancer guided by comprehensive geriatric assessment within a multidisciplinary team—a multicenter phase II trial

The purpose of this study was to evaluate the safety and efficacy of preoperative concurrent chemoradiotherapy (preCRT) for locally advanced rectal cancer in older people who were classified as “fit” by compre...

Wen-Yang Liu, Yuan Tang, Ning Li, Yu Tang, Yun-Jie Cheng, Lin Yang… in BMC Geriatrics (2024)

Article

Association between mechanical power during one-lung ventilation and pulmonary complications after thoracoscopic lung resection surgery: a prospective observational study

The role of mechanical power on pulmonary outcomes after thoracic surgery with one-lung ventilation was unclear. We investigated the association between mechanical power and postoperative pulmonary complicatio...

Hong-Mei Liu, Gong-Wei Zhang, Hong Yu, Xue-Fei Li, Hai Yu in BMC Anesthesiology (2024)

Article

Precise planning based on 3D-printed dry-laboratory models can reduce perioperative complications of laparoscopic surgery for complex hepatobiliary diseases: a preoperative cohort study

Complications after laparoscopic liver resection (LLR) are important factors affecting the prognosis of patients, especially for complex hepatobiliary diseases. The present study aimed to evaluate the value of...

Wei-Feng Yao, **ao-Kun Huang, Tian-Wei Fu, Lei **, Cheng-Fei Du… in BMC Surgery (2024)

Article

Skin mottling score assesses peripheral tissue hypoperfusion in critically ill patients following cardiac surgery

Skin mottling is a common manifestation of peripheral tissue hypoperfusion, and its severity can be described using the skin mottling score (SMS). This study aims to evaluate the value of the SMS in detecting ...

**g-chao Luo, Ming-hao Luo, Yi-jie Zhang, Wen-jun Liu, Guo-guang Ma… in BMC Anesthesiology (2024)

Article

Evaluation of disease severity and prediction of severe cases in children hospitalized with influenza A (H1N1) infection during the post-COVID-19 era: a multicenter retrospective study

The rebound of influenza A (H1N1) infection in post-COVID-19 era recently attracted enormous attention due the rapidly increased number of pediatric hospitalizations and the changed characteristics compared to...

Hai-Feng Liu, **ao-Zhong Hu, Rong-Wei Huang, Zheng-Hong Guo, **-Rong Gao… in BMC Pediatrics (2024)

Article

Correction to: Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study

Ko-Ting Chen, Chiung-Yin Huang, **-Ching Pai, Wen-Chi Yang… in Journal of Neuro-Oncology (2024)

Article

Early and mid-term outcomes of open thoracoabdominal aortic aneurysm repair after thoracic endovascular aortic repair

To evaluate the early and mid-term outcomes of open repair in patients with thoracoabdominal aortic aneurysm (TAAA) after thoracic endovascular aortic repair (TEVAR).

Ji Lin, Wei Liu, Cheng-Wei Yang, Kaitao Jian, Yu **a… in BMC Cardiovascular Disorders (2024)

Article

Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure

Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data of elevated INR l...

Dong-Dong Wang, Meng-Meng Dong, Ya-Ming **e, Fei-Qi Xu, Tian-Wei Fu… in Discover Oncology (2024)

Article

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

The autonomic nervous system plays a crucial role in regulating bone metabolism, with sympathetic activation stimulating bone resorption and inhibiting bone formation. We found that fractures lead to increased...

Jie Huang, Tong Wu, Yi-Rong Jiang, Xuan-Qi Zheng, Huan Wang, Hao Liu… in Bone Research (2024)

Article

Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the spec...

Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui **ong, **g-Ru Lv… in Military Medical Research (2024)

Article

Effect of Postoperative Prolonged sedation with Dexmedetomidine after successful reperfusion with Endovascular Thrombectomy on long-term prognosis in patients with acute ischemic stroke (PPDET): study protocol for a randomized controlled trial

Endovascular thrombectomy (EVT) is a standard treatment for acute ischemic stroke (AIS) with large vessel occlusion. Hypertension and increased blood pressure variability within the first 24 h after successful...

Li-na Yang, Yi Sun, Yu-zhu Wang, **g Wang, Yi-sha Qi, Shan-shan Mu, Yun-peng Liu… in Trials (2024)

Article

The body mass index and the risk of ectopic pregnancy: a 5-year retrospective case-control study

Acknowledging the associated risk factors may have a positive impact on reducing the incidence of ectopic pregnancy (EP). In recent years, body mass index (BMI) has been mentioned in research. However, few stu...

**-Shuang Ji, Ling Liu, Huan Huang, Hong-Wei Chen, Li **ao… in BMC Pregnancy and Childbirth (2024)

Article

Risk, Predictive, and Preventive Factors for Noninfectious Ventriculitis and External Ventricular Drain Infection

External ventricular drain (EVD) is used for monitoring intracranial pressure or diverting cerebrospinal fluid. However, confirmation of an infection is not immediate and requires obtaining culture results, of...

Tzu-Fen Huang, Yu-Kai Su, I-Chang Su, Yun-Kai Yeh, Heng-Wei Liu… in Neurocritical Care (2024)

Article

A literature review and meta-analysis of the optimal factors study of repetitive transcranial magnetic stimulation in post-infarction aphasia

The existing literature indicates that repetitive transcranial magnetic stimulation (rTMS) can potentially enhance the prognosis of poststroke aphasia (PSA). Nevertheless, these investigations did not identify...

Yang Tan, Lin-Ming Zhang, **ng-ling Liang… in European Journal of Medical Research (2024)

Article

Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis

Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been proposed as an early indicator of acute kidney injur...

Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng… in Critical Care (2023)

Article

Probucol attenuates high glucose-induced Müller cell damage through enhancing the Nrf2/p62 signaling pathway

This study investigated the protective effect of probucol on Müller cells exposed to high glucose conditions and examined potential mechanisms of action.

Yu-Fan Zhou, Heng-Wei Liu, Xu Yang, Chen-**ang Li… in International Ophthalmology (2023)

Article

Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study

High-power short-duration (HPSD) ablation strategy has emerged as a popular approach for treating atrial fibrillation (AF), with shorter ablation time. The utilized Smart Touch Surround Flow (STSF) catheter, w...

Wei-Jie Chen, Chun-**a Gan, Yang-Wei Cai, Yang-Yang Liu, Pei-Lin **ao… in BMC Medicine (2023)

Article

A modified Blumgart anastomosis with a simple and practicable procedure after laparoscopic pancreaticoduodenectomy: our center’s experience

Laparoscopic pancreaticoduodenectomy(LPD) has become the goal of lots of minimally invasive surgical centers in recent years. Postoperative pancreatic fistula(POPF) is still the barrier to attaining the above ...

Guo-Hua Liu, **ao-Yu Tan, Jia-**ng Li, Guo-Hui Zhong, **g-Wei Zhai… in BMC Surgery (2023)