62 Result(s)
within
**g-Shan Yang
English
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessThe sequence and de novo assembly of the giant panda genome
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% o...
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Article
Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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Article
Open AccessZebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress
Aberrant DNA hypermethylation is frequently found in tumor cells and inhibition of DNA methylation is an effective anticancer strategy. In this study, the therapeutic effect of DNA methyltransferase (DNMT) inh...
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Article
Open AccessCharge deformation and orbital hybridization: intrinsic mechanisms on tunable chromaticity of Y3Al5O12:Ce3+ luminescence by do** Gd3+ for warm white LEDs
The deficiency of Y3Al5O12:Ce (YAG:Ce) luminescence in red component can be compensated by do** Gd3+, thus lead to it being widely used for packaging warm white light-emitting diode devices. This article presen...
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Open AccessTransforming berberine into its intestine-absorbable form by the gut microbiota
The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on the interaction between intestinal bacteria and orally administered chemical drugs. Oral administration ...
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Open AccessThe structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division
During the asymmetric division of Drosophila neuroblasts (NBs), the scaffold Miranda (Mira) coordinates the subcellular distribution of cell-fate determinants including Staufen (Stau) and segregates them into the...
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Open AccessLoss of KLF14 triggers centrosome amplification and tumorigenesis
Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice causes centrosome amplification, ane...
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Open AccessCarrier-mediated ferromagnetism in the magnetic topological insulator Cr-doped (Sb,Bi)2Te3
Magnetically doped topological insulators, possessing an energy gap created at the Dirac point through time-reversal-symmetry breaking, are predicted to exhibit exotic phenomena including the quantized anomalo...
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Open AccessThe Dendrobium catenatum Lindl. genome sequence provides insights into polysaccharide synthase, floral development and adaptive evolution
Orchids make up about 10% of all seed plant species, have great economical value and are of specific scientific interest because of their renowned flowers and ecological adaptations. Here, we report the first ...
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Article
Open AccessFlavone synthases from Lonicera japonica and L. macranthoides reveal differential flavone accumulation
Flavones are important secondary metabolites found in many plants. In Lonicera species, flavones contribute both physiological and pharmaceutical properties. However, flavone synthase (FNS), the key enzyme respon...
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Open AccessAltered brain activation and functional connectivity in working memory related networks in patients with type 2 diabetes: An ICA-based analysis
Type 2 diabetes mellitus (T2DM) can cause multidimensional cognitive deficits, among which working memory (WM) is usually involved at an early stage. However, the neural substrates underlying impaired WM in T2...
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Open AccessSegregation between the parietal memory network and the default mode network: effects of spatial smoothing and model order in ICA
A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with t...
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Open AccessContrast-enhanced transrectal ultrasound for prediction of prostate cancer aggressiveness: The role of normal peripheral zone time-intensity curves
To assess the role of time-intensity curves (TICs) of the normal peripheral zone (PZ) in the identification of biopsy-proven prostate nodules using contrast-enhanced transrectal ultrasound (CETRUS). This study...
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Article
Open AccessSerotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease
Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and...
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Open AccessPhenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters
Parkinson disease (PD) is identified as tremor-dominant (TD) and postural instability and gait difficulty (PIGD) phenotypes. The relationships between motor phenotypes and cognitive impairment and the underlyi...
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Open AccessIdentification of a nanobody specific to human pulmonary surfactant protein A
Nanobody (Nb) is a promising vector for targeted drug delivery. This study aims to identify an Nb that can specifically target the lung by binding human pulmonary surfactant protein A (SP-A). Human lung frozen...
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Article
Open AccessMicroRNA-29a Counteracts Synovitis in Knee Osteoarthritis Pathogenesis by Targeting VEGF
Synovitis contributes to the development of osteoarthritis (OA) of the knee. MicroRNAs regulate joint microenvironment homeostasis and deterioration. This study was undertaken to characterize the actions of mi...
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Open AccessCbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full activation of JAK2 are unclear. Here, we report a positive role for ...
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Open AccessInfluence of Latent Heating over the Asian and Western Pacific Monsoon Region on Sahel Summer Rainfall
There has been an interdecadal shift towards a less humid state in Sahel summer rainfall since the 1960s. The decreased Sahel summer rainfall was associated with enhanced summer latent heating over the South A...
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Open AccessSusceptibility of influenza A(H1N1)/pdm2009, seasonal A(H3N2) and B viruses to Oseltamivir in Guangdong, China between 2009 and 2014
Nasopharyngeal swabs were collected from patients through the influenza surveillance network of the CDC of Guangdong. All specimens between 2009 and 2014 were checked for influenza virus using MDCK cells and f...
