3,138 Result(s)
within
**g-Liang Chen
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Article
Oxidation behavior of Ni-based superalloy GH4738 under tensile stress
Revealing the oxidation behavior of superalloys is crucial for optimizing material properties and extending service life. This study investigated the oxidation behavior of superalloy GH4738 under stress states...
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Open AccessSurvival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...
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Article
Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease
Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is related to th...
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Synthesis of SrAl2O4: Eu, DY @ polymer composite membrane using eugenol as a cross-linking agent to minimize nanoparticle agglomeration
Long afterglow nanoparticles, a type of luminescence material, may gradually release stored light energy even after the excitation light has stopped. The modification of polymer membranes by introducing long a...
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Open AccessUltrafast Response and Threshold Adjustable Intelligent Thermoelectric Systems for Next-Generation Self-Powered Remote IoT Fire Warning
The flexible single-walled carbon nanotube/titanium carbide composite films exhibit excellent thermoelectric (TE), high-temperature stable and flame-retardant properties.
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Open AccessReactive oxygen species/glutathione dual sensitive nanoparticles with encapsulation of miR155 and curcumin for synergized cancer immunotherapy
Considerable attention has been directed towards exploring the potential efficacy of miR-155 in the realm of cancer immunotherapy. Elevated levels of miR-155 in dendritic cells (DCs) have been shown to enhance...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the treatment of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Und...
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CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are limited. We developed CRISPRdelight, a DNA-labeling system base...
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Prior herpes zoster occurrence and high-dose corticosteroids increase herpes zoster risk in rheumatoid arthritis patients receiving janus kinase inhibitors in a retrospective and observational study
Herpes zoster (HZ) risk is increased in rheumatoid arthritis (RA) patients receiving Janus kinase inhibitors (JAKi) therapy. Identifying and evaluating the risk factors of HZ development in patients receiving ...
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Article
Foxg1 Modulation of the Prkcd Gene in the Lateral Habenula Mediates Trigeminal Neuralgia-Associated Anxiety-Like Behaviors in Mice
Trigeminal Neuralgia (TN) is a debilitating disorder frequently accompanied by mood complications such as depression and anxiety. The current study sought to elucidate the molecular underpinnings that contribu...
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Open AccessNon-Abelian braiding of Fibonacci anyons with a superconducting processor
Quantum many-body systems with a non-Abelian topological order can host anyonic quasiparticles. It has been proposed that anyons could be used to encode and manipulate information in a topologically protected ...
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Thermoelectric transport properties of p-type Bi2Se3–Sb2Se3–In2Se3 high entropy compounds
The introduction of entropy concept into thermoelectric materials recently has attracted broad interest. Herein, we showed the phase diagram of the ternary systems of Bi2Se3–Sb2Se3–In2Se3. Among the high entropy ...
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Article
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65−/−) mice exhibit a...
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Article
Toward a solid microneedle patch for rapid and enhanced local analgesic action
Analgesic creams find widespread application as adjuncts for localized anesthesia prior to surgical procedures. Nevertheless, the onset of analgesic action is protracted due to the skin barrier’s inherent char...
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Open AccessA Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19
Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of ropeginterferon alfa-2b against SARS-CoV-2 infection.
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Article
Global–local Bi-alignment for purer unsupervised domain adaptation
Unsupervised domain adaptation (UDA) aims to extract domain-invariant features. Existing UDA methods mainly utilize a convolutional neural network (CNN) or vision transformer (ViT) as feature extractor, which ...
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Article
Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Status epilepticus (SE), a serious and often life-threatening medical emergency, is characterized by abnormally prolonged seizures. It is not effectively managed by present first-line anti-seizure medications ...
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Assessing the range of blasting-induced cracks in the surrounding rock of deeply buried tunnels based on the unified strength theory
Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse, posing significant safety risks. However, previous theoretical studies on the range of ...
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Open AccessSearch for long-lived heavy neutrinos in the decays of B mesons produced in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
A search for long-lived heavy neutrinos (N) in the decays of B mesons produced in proton-proton collisions at ...
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Article
H2O2-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors
Photodynamic therapy (PDT) has been emerged as a promising modality for cancer treatment. However, the development of drug delivery system enabling continuous release of photosensitizers (PSs) for long-term PD...
