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Open AccessBiological characteristics of molecular subtypes of ulcerative colitis characterized by ferroptosis and neutrophil infiltration
Clinical ulcerative colitis (UC) is a heterogeneous condition. Moreover, medical interventions are nonspecific, and thus, treatment responses are inconsistent. The aim of this study was to explore the molecula...
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Article
Open AccessUndrained shear behavior of silty sand with a constant state parameter considering initial stress anisotropy effect
Field observations in sedimentation and erosion-prone areas indicate that most natural sand deposits may contain a certain amount of non-plastic fines and are often under anisotropic stress conditions. A serie...
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Article
Open AccessA chromosome-level genome assembly of tomato pinworm, Tuta absoluta
The tomato pinworm, Tuta absoluta, or Phthorimaea absouta, is native to South America, but quickly spread to other regions of world, including Europe, Africa, and Asia, devastating to global tomato production....
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Open AccessA new protective gel to facilitate ulcer healing in artificial ulcers following oesophageal endoscopic submucosal dissection: a multicentre, randomized trial
There are significant risks of adverse events following oesophageal endoscopic submucosal dissection (ESD), such as stricture, delayed bleeding and perforation. Therefore, it is necessary to protect artificial...
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Open AccessMitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression
Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitocho...
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Open AccessIdentification of AKIRIN2 as a potential biomarker and correlation with immunotherapy in gastric adenocarcinoma by integrated bioinformatics analysis
Gastric adenocarcinoma is major type of gastric cancer that endangers human health. AKIRIN2 has been shown to be associated with cholangiocarcinoma promoting invasion and angiogenesis. In this study, AKIRIN2 i...
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Article
Genome-edited powdery mildew resistance in wheat without growth penalties
Disruption of susceptibility (S) genes in crops is an attractive breeding strategy for conferring disease resistance1,2. However, S genes are implicated in many essential biological functions and deletion of thes...
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Open AccessAuthor Correction: Climate variations of Central Asia on orbital to millennial timescales
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessAuthor Correction: Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
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Open AccessQuantitative analysis of contrast enhanced spectral mammography grey value for early prediction of pathological response of breast cancer to neoadjuvant chemotherapy
A quantitative analysis of contrast-enhanced spectral mammography (CESM) enhancement was conducted for the early prediction of the pathological response after neoadjuvant chemotherapy (NAC). Retrospective anal...
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Open AccessSingle-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major ce...
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Open AccessCo-expression of mFat-1 and pig IGF-1 genes by recombinant plasmids in modified chitosan nanoparticles and its synergistic effect on mouse immunity
To develop a cost-effective molecular regulator to improve growth metabolism and immunity of animals, a recombinant plasmid co-expressing fatty acid desaturase (mFat-1) and pig insulin growth like factor 1 (IG...
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Open AccessHeart function and thoracic aorta gene expression profiling studies of ginseng combined with different herbal medicines in eNOS knockout mice
Ginseng, a popular herbal remedy, is often used in combination with other drugs to achieve the maximum therapeutic response. Shenfu (SFI) and Shenmai injection (SMI) have been widely used to treat cardiovascul...
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Open AccessPrenatal chromium exposure and risk of preterm birth: a cohort study in Hubei, China
Few studies have investigated the association of environmental chromium exposure and preterm birth in general population. This study was designed to investigate whether maternal chromium exposure during pregna...
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Article
Open AccessPrognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors
Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and t...
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Open AccessEvaluation of the Effects of Conjunctivochalasis Excision on Tear Stability and Contrast Sensitivity
Conjunctivochalasis (CCh) disrupts tear flow and damages tear film stability. This study sought to evaluate the tear stability and contrast sensitivity of patients with CCh on whom CCh excision was performed. ...
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Open AccessClimate variations of Central Asia on orbital to millennial timescales
The extent to which climate variability in Central Asia is causally linked to large-scale changes in the Asian monsoon on varying timescales remains a longstanding question. Here we present precisely dated hig...
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Open AccessLncRNA PANDAR regulates the G1/S transition of breast cancer cells by suppressing p16INK4A expression
It has been reported that lncRNA PANDAR (promoter of CDKN1A antisense DNA damage-activated RNA) is induced as a result of DNA damage, and it regulates the reparation of DNA damage. In this study, we investigat...
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Open AccessSUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer
SUN2, a key component of LINC (linker of nucleoskeleton and cytoskeleton) complex located at the inner nuclear membrane, plays unknown role in lung cancer. We found that SUN2 expression was decreased in lung c...
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BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10
BRMS1L (breast cancer metastasis suppressor 1 like, BRMS1-like) is a component of Sin3A–histone deacetylase (HDAC) co-repressor complex that suppresses target gene transcription. Here we show that reduced BRMS...