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Article
Long-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation
Preserving the functionality of hepatocytes in vitro poses a significant challenge in liver tissue engineering and bioartificial liver, as these cells rapidly lose their metabolic and functional characteristics a...
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Article
Open AccessAuthor Correction: Regulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury
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Article
Open AccessThe Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2
Transcription factors are essential for the development and regeneration of the nervous system. The current study investigated key regulatory transcription factors in rat spinal cord development via RNA sequen...
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Article
Open AccessThe impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies
Immunotherapy is one of the fastest develo** areas in the field of oncology. Many immunological treatment strategies for refractory tumors have been approved and marketed. Nevertheless, much clinical and pre...
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Article
Controlled delivery of a neurotransmitter–agonist conjugate for functional recovery after severe spinal cord injury
Despite considerable unmet medical needs, effective pharmacological treatments that promote functional recovery after spinal cord injury remain limited. Although multiple pathological events are implicated in ...
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Article
Open AccessAuthor Correction: Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury
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Open AccessPorous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury
The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation. However, efficient delive...
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Article
Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration
Repair of long-distance peripheral nerve defects remains an important clinical problem. Nerve grafts incorporated with extracellular vesicles (EVs) from various cell types have been developed to bridge periphe...
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Article
Open AccessSpatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors – the glial scar is triggered by injury and inhibits or promotes regener...
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Article
Open AccessIntegrated analyses reveal evolutionarily conserved and specific injury response genes in dorsal root ganglion
Rodent dorsal root ganglion (DRG) is widely used for studying axonal injury. Extensive studies have explored genome-wide profiles on rodent DRGs under peripheral nerve insults. However, systematic integration ...
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Article
CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer
Circular RNA (circRNA) tubulin gamma complex associated protein 3 (circTUBGCP3) has been reported to play an oncogenic role in colorectal cancer and osteosarcoma.
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Article
Molecular landscapes of human hippocampal immature neurons across lifespan
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents1,2 and are dysregulated in multiple human neurological disorders3–
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Article
Open AccessBUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability
Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow characterized by chromosome instability (CIN), which contributes to the acquisition of heterogeneity, along with MM progression, ...
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Article
Open AccessIdentification of prognostic immune-related gene signature associated with tumor microenvironment of colorectal cancer
The tumor microenvironment (TME) has significantly correlation with tumor occurrence and prognosis. Our study aimed to identify the prognostic immune-related genes (IRGs)in the tumor microenvironment of colore...
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Article
miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3
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Open AccessMolecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson’s Disease Mice Model Revealed by Transcriptome
Parkinson’s disease (PD) is a neurodegenerative disease caused by a variety of unclear complex pathogenic factors. The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/probenecid (MPTP/p)-induced progressive PD...
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Article
Open AccessOpen versus endoscopic carpal tunnel release: a systematic review and meta-analysis of randomized controlled trials
Endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR) both have advantages and disadvantages for the treatment of carpal tunnel syndrome (CTS). We compared the effectiveness and safety ...
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Article
Visible-light-responsive photocatalyst with a microsphere structure: preparation and photocatalytic performance of CQDs@BiOCl
In this study, the effects of carbon quantum dot (CQD) do** on the photocatalytic performance of semiconductor BiOCl microspheres were investigated. Highly dispersed CQDs with up-conversion luminescence prop...
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Article
The preparation and photocatalytic performance of BiOCl@Ag, a visible-light responsive catalyst
The effect of noble metal silver (Ag) modification on the photocatalytic performance of layered BiOCl microspheres was investigated herein. BiOCl@Ag, a visible-light-responsive photocatalyst with regular morph...
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Article
Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury
The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby th...
