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Open AccessDetection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics
Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers. The a...
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Article
Open AccessLocal resection via partial lamellar sclerouvectomy for ciliary body tumors — a case series
Ciliary body tumor is extremely rare and treatment is challenging. The aim of this study is to present our experience in treating this rare entity, especially large tumors with more than 5 clock hours of invol...
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Article
Open AccessClinicopathological characteristics and prognosis of metaplastic breast cancer versus triple-negative invasive ductal carcinoma: a retrospective analysis
Metaplastic breast cancer(MBC) is a specific pathological type of invasive breast cancer. There are few studies related to MBC due to its rarity. This study aimed to analyse the differences in clinicopathologi...
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Article
Open AccessRelationship between C2 slope with sagittal parameters and clinical function of degenerative cervical kyphosis
To explore the relationship between C2 slope with sagittal parameters and clinical function of degenerative cervical kyphosis (DCK).
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Article
Open AccessAuthor Correction: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
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Article
Open AccessEpigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34...
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Article
Open AccessUltra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma: a prospective study
This single-arm, prospective, exploratory study investigated the effectiveness of ultra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma (OAL).
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Article
Open AccessDietary exposure of radionuclides and heavy metals in adult residents in a high background natural radiation area using duplicate diet method
Intake of radionuclides and heavy metals through food consumption is one of the important pathways for long-term health considerations. In this paper, the dietary exposure to radionuclides (210Pb, 210Po, 226Ra, 2...
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Article
Programmable RNA sensing for cell monitoring and manipulation
RNA is a central and universal mediator of genetic information underlying the diversity of cell types and cell states, which together shape tissue organization and organismal function across species and lifesp...
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Article
Open AccessSpatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucle...
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Article
Open AccessDivergent patterns of selection on metabolite levels and gene expression
Natural selection can act on multiple genes in the same pathway, leading to polygenic adaptation. For example, adaptive changes were found to down-regulate six genes involved in ergosterol biosynthesis—an esse...
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Article
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination
The extracellular-signal-regulated kinases ERK1 and ERK2 (hereafter ERK1/2) represent the foremost mitogenic pathway in mammalian cells, and their dysregulation drives tumorigenesis and confers therapeutic res...
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Article
DAXX represents a new type of protein-folding enabler
Protein quality control systems are crucial for cellular function and organismal health. At present, most known protein quality control systems are multicomponent machineries that operate via ATP-regulated int...
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Article
Evaluation of the natural radioactivity in food and soil around uranium mining region
To evaluate the radiological risk to human health associated with the ingestion of radionuclides in foods, some different plant foods cultivated in the mining area were collected and analyzed. Results showed t...
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Natural radionuclides distribution, depth profiles of caesium-137 and risk assessment for soil samples in west regions of China
An analysis of natural radioactivity in soils collected around Chinese Nuclear Test site is presented. The radioactivities of 238U, 226Ra, 232Th, 40K, and 137Cs were determined by HPGe gamma-ray spectrometry, and...
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Article
Open AccessTRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
Tumor cells often exhibit augmented capacity to maintain endoplasmic reticulum (ER) homeostasis under adverse conditions, yet the underlying mechanisms are not well defined. Here, through the evaluation of all...
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Open AccessKS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
Uveitis is a potentially sight-threatening form of ocular inflammation that affects the uvea in the wall of the eye. Currently available treatments for uveitis have exhibited profound adverse side effects. How...
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Open AccessThe lncRNA Neat1 promotes activation of inflammasomes in macrophages
The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several inflammasomes. Neat1 associates with the...
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Assessment of radioactivity level and associated radiation exposure in topsoil from eastern region of Shangrao Prefecture, China
Natural and fallout radioactivity were estimated in topsoil samples collected in eastern region of Shangrao Prefecture, China. The average activity concentrations of 238U, 226Ra, 232Th and 40K in the soil were ne...
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Article
Grammatical Aspect in Early Child Mandarin: Evidence from a Preferential Looking Experiment
The study assessed 30-month-old Mandarin-speaking children’s awareness of aspectual distinctions involving the perfective marker le and the imperfective marker zhe in a preferential looking experiment. In the exp...
