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Article
BIS5k: a large-scale dataset for medical segmentation task based on HE-staining images of breast cancer
Breast cancer, a high-incidence cancer among female, occupies a large incidence of total female patients with cancer. Pathological examination is the gold standard for breast cancer in clinic diagnosis. Howeve...
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Article
Research on highly sensitive detection of clenbuterol hydrochloride based on THz metamaterial enhancement
The abuse of clenbuterol hydrochloride (CL) is a serious threat to people’s life and health. The traditional THz detection method can only detect the sample at the milligram level, which is not suitable for tr...
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Article
Cas13a-based multiplex RNA targeting for potato virus Y
The Cas13a-based multiplex RNA targeting system can be engineered to confer resistance to RNA viruses, whereas the number and expression levels of gRNAs have no significant effect on viral interference.
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Article
Open AccessCas13d-mediated multiplex RNA targeting confers a broad-spectrum resistance against RNA viruses in potato
CRISPR-Cas systems endow the bacterial and archaeal species with adaptive immune mechanisms to fend off invading phages and foreign plasmids. The class 2 type VI CRISPR/Cas effector Cas13d has been harnessed t...
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Article
Open AccessCausal Associations Between Tobacco, Alcohol Use and Risk of Infectious Diseases: A Mendelian Randomization Study
The causal effects of smoking and alcohol use on the risk of infectious diseases are unclear, and it is hard investigate them in an observational study due to the potential confounding factors. The aim of this...
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Chapter
Image Domain Performance Evaluation of a Photon-counting ASIC Using a Multilayer Perceptron Network
Photon-Counting Computed Tomography (PCCT) has great potential to transform clinical applications. One of the essential tasks during system development is to compare performance between different ASIC designs....
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Chapter and Conference Paper
Constrained Graph Searching on Trees
Megiddo et al. (1988) introduced the edge searching problem, which is to find the minimum number of searchers to capture the robber in the edge searching model. Dyer et al. (2008) introduced the fast searching...
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Article
Open AccessIn silico Methods for Identification of Potential Therapeutic Targets
At the initial stage of drug discovery, identifying novel targets with maximal efficacy and minimal side effects can improve the success rate and portfolio value of drug discovery projects while simultaneously...
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Article
Author Correction: Measurement of the generalized spin polarizabilities of the neutron in the low-Q2 region
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Article
Open AccessTetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects
Recently, DNA nanostructures with vast application potential in the field of biomedicine, especially in drug delivery. Among these, tetrahedral DNA nanostructures (TDN) have attracted interest worldwide due to...
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Article
Measurement of the generalized spin polarizabilities of the neutron in the low-Q2 region
Understanding the nucleon spin structure in the regime where the strong interaction becomes truly strong poses a challenge to both experiment and theory. At energy scales below the nucleon mass of about 1 GeV,...
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Article
Hyperconnection and hyperperfusion of overlap** brain regions in patients with menstrual-related migraine: a multimodal neuroimaging study
Menstrual-related migraine (MRM) results in moderate to severe intensity headaches accompanied by physical and emotional disability over time in women. Neuroimaging methodologies have advanced our understandin...
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Chapter and Conference Paper
Generating Pseudo Connectives with MLMs for Implicit Discourse Relation Recognition
Due to the lack of connectives, the recognition of implicit discourse relations faces a big challenge. An early attempt overcomes this difficulty by predicting connectives with the use of the statistical langu...
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Chapter and Conference Paper
The Privacy Data Protection Model Based on Random Projection Technology
In general, as the technology developed, big data analysis provides opportunities to reduce the implementation time and budget. Compared with traditional methods, big data analysis has a greater advantage. It ...
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Article
Open AccessA pan-kidney cancer study identifies subtype specific perturbations on pathways with potential drivers in renal cell carcinoma
Renal cell carcinoma (RCC) is a complex disease and is comprised of several histological subtypes, the most frequent of which are clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (PRCC) ...
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Article
Open AccessDeep learning-based cancer survival prognosis from RNA-seq data: approaches and evaluations
Recent advances in kernel-based Deep Learning models have introduced a new era in medical research. Originally designed for pattern recognition and image processing, Deep Learning models are now applied to sur...
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Article
Surfactant-enhanced biodegradation of crude oil by mixed bacterial consortium in contaminated soil
This study evaluated the effects of two surfactants (i.e., Tween 80 and SDS) on biodegradation of crude oil by mixed bacterial consortium in soil-aqueous system. The mixed bacterial consortium was domesticated...
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Article
Open AccessGenomics alterations of metastatic and primary tissues across 15 cancer types
Metastasis is an important event for cancer evolution and prognosis. In this article, we analyzed the differences in genomic alterations between primary and metastatic tissues at hotspot regions in 15 cancer t...
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Article
Open AccessStrong and highly asymmetrical optical absorption in conformal metal-semiconductor-metal grating system for plasmonic hot-electron photodetection application
We propose an architecture of conformal metal-semiconductor-metal (MSM) device for hot-electron photodetection by asymmetrical alignment of the semiconductor barrier relative to the Fermi level of metals and s...
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Article
Von Hippel-Lindau disease type 2 in a Chinese family with a VHL p.W88X truncation
Von Hippel-Lindau (VHL) disease is an autosomal dominant syndrome caused by germline mutations in the synonymous VHL gene encoding a tumor suppressor. Affected individuals are susceptible to various benign and...
