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Article
Open AccessMicroglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices
Acute brain slices represent a workhorse model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue damage, it is unclear ...
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Article
Open AccessThe impact of provider-patient communication skills on primary healthcare quality and patient satisfaction in rural China: insights from a standardized patient study
In middle-income countries, poor physician-patient communication remains a recognized barrier to enhancing healthcare quality and patient satisfaction. This study investigates the influence of provider-patient...
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Article
Influenza A Virus PB1-F2 Induces Affective Disorder by Interfering Synaptic Plasticity in Hippocampal Dentate Gyrus
Influenza A virus (IAV) infection, which leads to millions of new cases annually, affects many tissues and organs of the human body, including the central nervous system (CNS). The incidence of affective disor...
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Article
Open AccessFoliar application of strigolactones improves the desiccation tolerance, grain yield and water use efficiency in dryland wheat through modulation of non-hydraulic root signals and antioxidant defense
Non-hydraulic root signals (nHRS) are affirmed as a unique positive response to soil drying, and play a crucial role in regulating water use efficiency and yield formation in dryland wheat production. Strigola...
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Article
Construction of pH-universal hydrogen evolution freeway in MoO3-MoNi4@Cu core–shell nanowires via synergetic electronic and geometric effect
Both the adsorption/dissociation of water molecules and hydrogen intermediate (H*) are the major limitations to hydrogen evolution reaction (HER). Herein, the modulation of electronic structure and geometric c...
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Article
Metal-organic framework derived NiFe2O4/FeNi3@C composite for efficient electrocatalytic oxygen evolution reaction
Reducing the cost and improving the electrocatalytic activity are the key to develo** high efficiency electrocatalysts for oxygen evolution reaction (OER). Here, bimetallic NiFe-based metal-organic framework...
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Article
Recent progress of two-dimensional metal-organic-frameworks: From synthesis to electrocatalytic oxygen evolution
High-performance electrocatalysts for oxygen evolution reaction (OER) are crucial for water splitting and metal-air batteries. Two-dimensional (2D) metal-organic framework (MOF) has become a new class of effic...
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Article
Phosphorus-doped iron-nitrogen-carbon catalyst with penta-coordinated single atom sites for efficient oxygen reduction
Single-atomic Fe-N4 is the well-acknowledged active site in iron-nitrogen-carbon (Fe-N-C) material for oxygen reduction reaction (ORR). The adjusting of the electronic distribution of Fe-N4 is promising for furth...
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Article
Open AccessPrevalence and distribution of human papillomavirus genotypes among women attending gynecology clinics in northern Henan Province of China
Human papillomavirus (HPV) infection can cause cervical and other cancers, including vulva, vagina, penis, anus, or oropharynx. However, in China's northern Henan Province, data on the prevalence and genotype ...
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Article
Open AccessA non-printed integrated-circuit textile for wireless theranostics
While the printed circuit board (PCB) has been widely considered as the building block of integrated electronics, the world is switching to pursue new ways of merging integrated electronic circuits with textil...
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Article
Open AccessAstaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats
Ischemia-reperfusion injury of the spinal cord (SCII) often leads to unalterable neurological deficits, which may be associated with apoptosis induced by oxidative stress and inflammation. Astaxanthin (AST) is...
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Article
Open AccessA rare simultaneous coexistence of epithelioid gastrointestinal stromal tumors and schwannoma in the stomach: a case report
Gastrointestinal stromal tumors (GISTs), a type of mesenchymal tumor in the gastrointestinal tract, are believed to be closely associated with PDGFRA and C-KIT mutations. Schwannoma in the stomach, which is an...
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Article
Open AccessIn vitro transcribed sgRNA causes cell death by inducing interferon release
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Open Access5′ capped and 3′ polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system
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Article
Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2/prostaglandin E2 content
Taxifolin is a potent flavonoid with anti-inflammatory activity. Taxifolin has been reported to decrease the accumulation of β-amyloid (Aβ), and reduce Aβ-induced neurotoxicity. However, the detail molecular m...
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Article
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the tr...
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Article
CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells
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Article
Synthesis and tumor cytotoxicity of novel 1,2,3-triazole-substituted 3-oxo-oleanolic acid derivatives
Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1,2,3-triazolyl methyl moiety were synthesized via the method of Copper(I)-catalyzed Huisgen cycloaddition. The cytotoxicity evaluation results o...
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Article
Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway
Bis(propyl)-cognitin (B3C), derived from tacrine linked with three methylene (–CH2–) groups, is a dimerized molecule interacting multiple targets. During the past several years, it has been reported as a promi...
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Article
Chronic inflammatory pain upregulates expression of P2Y2 receptor in small-diameter sensory neurons
Roles of ionotropic purinergic (P2X) receptors in chronic pain have been intensively investigated. However, the contribution of metabotropic purinergic (P2Y) receptors to pathological pain is controversial. In...
