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Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes in energy metabolic pathways in cancer cells has become key to address this issue. Euka...
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Ultrathin GaN Film Derived from Amorphous Ga2O3 Film
It remains a big challenge to synthesize two-dimensional (2D) GaN material for applications in power nanodevices. Traditional synthetic methods require complex equipment and processes and time consuming. Here,...
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Open AccessInvestigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma
Osteosarcoma (OS), the most common primary malignant bone tumor, predominantly affects children and young adults and is characterized by high invasiveness and poor prognosis. Despite therapeutic advancements, ...
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Open AccessPerturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging
Cellular senescence is characterized by a decrease in protein synthesis, although the underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) frequently influence tRNA activity...
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Open AccessMachine learning models to predict systemic inflammatory response syndrome after percutaneous nephrolithotomy
The objective of this study was to develop and evaluate the performance of machine learning models for predicting the possibility of systemic inflammatory response syndrome (SIRS) following percutaneous nephro...
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Open AccessWorking with AI: the impact of organizational intelligent service strategy on employees’ perception of career achievement
In the artificial intelligence (AI) environment, there is limited research on employees’ perception of career achievement. Previous literature has presented two different viewpoints: AI either reduces or incre...
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A randomized block Douglas–Rachford method for solving linear matrix equation
The Douglas-Rachford method (DR) is one of the most computationally efficient iterative methods for the large scale linear systems of equations. Based on the randomized alternating reflection and relaxation st...
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Effects of ionic strength and bentonite ratio on the migration of Cr(VI) in clayey soil-bentonite engineered barrier
Soil-bentonite (S-B) barriers have been widely used for heavy metal pollution containment. This study conducted batch adsorption tests and diffusion-through tests to evaluate how ionic strength and bentonite r...
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Open AccessAdvances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune...
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Open AccessCRISPR-Cas3 and type I restriction-modification team up against blaKPC-IncF plasmid transfer in Klebsiella pneumoniae
We explored whether the Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas and restriction-modification (R-M) systems are compatible and act together to resist plasmid attacks.
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Preparation, Curing and Properties of Liquid Amine-Terminated Fluoroelastomers
A two-step nucleophilic substitution mechanism was used and described to prepare liquid amine-terminated fluoroelastomers (LTAFs) by using liquid hydroxy-terminated fluoroelastomers (LTHFs) as raw materials, b...
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Open AccessZona incerta mediates early life isoflurane-induced fear memory deficits
The potential long-term effects of anesthesia on cognitive development, especially in neonates and infants, have raised concerns. However, our understanding of its underlying mechanisms and effective treatment...
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Enhancing conductivity of Si anode enabled by selecting Si particle size for interface stabilized all-solid-state batteries
Silicon (Si) particle with small size used as anode material has been recognized for its ability to reduce the damage caused by volume expansion in liquid lithium-ion batteries. However, whether the same mecha...
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High-resolution tsunami hazard assessment for the Guangdong-Hong Kong-Macao Greater Bay Area based on a non-hydrostatic tsunami model
The Guangdong-Hong Kong-Macao Greater Bay Area (GBA) is threatened by potential tsunami hazards from the Littoral Fault Zone (LFZ) and the Manila subduction zone (MSZ), and may suffer huge damage because of it...
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Economic Evaluation of COVID-19 Immunization Strategies: A Systematic Review and Narrative Synthesis
This study aimed to systematically assess global economic evaluation studies on COVID-19 vaccination, offer valuable insights for future economic evaluations, and assist policymakers in making evidence-based d...
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Simulation and prediction of the dynamic evolution characteristics of resource- and technology-driven economic development models: a case study of the Yangtze River economic belt in China
Resource-driven models and technology-driven models appear in different stages of economic development. In the early stage of industrialization, resource-driven economic development is usually the main develop...
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Article
Observation of robust anisotropy in WS2/BP heterostructures
Two-dimensional (2D) anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical, optical, thermal, and mechanical properties...
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Simulation analysis of the start-up process of Carreau-type fluid slot die coating
The start-up process is important for ensuring the end quality of slot coating products. This study uses ANSYS Fluent to explore the start-up process of slot coating with Carreau-type non-Newtonian fluid. The ...
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Open AccessInfluenza virus uses mGluR2 as an endocytic receptor to enter cells
Influenza virus infection is initiated by the attachment of the viral haemagglutinin (HA) protein to sialic acid receptors on the host cell surface. Most virus particles enter cells through clathrin-mediated e...
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Isoflurane Preconditioning Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting miR-195-3p Expression
To investigate the role of microRNA-195-3p (miR-195-3p) in hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury. AC16 human cardiomyocyte cells were cultured and pretreated with different concentrations of...
