Parallel and Distributed Computing, Applications and Technologies
Proceedings of PDCAT 2023
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Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Article
Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study
To describe the treatment patterns and survival status of advanced gastric cancer (AGC) in China in the past two decades, and objectively evaluate the impact of standardized Chinese medicine (CM) treatment on ...
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Article
Prevalence, predictors, and outcomes of acute respiratory distress syndrome in severe stroke
Patients with severe stroke are at high risk of develo** acute respiratory distress syndrome (ARDS), but this severe complication was often under-diagnosed and rarely explored in stroke patients. We aimed to...
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Article
Open AccessThe effect of illness perception on psychosocial adjustment of patients with breast cancer and their spouses: actor–partner independence model
With the increase in the prevalence rate and improvements in the survival of breast cancer patients, there is a growing interest in understanding the level of psychosocial adjustment in these patients. The stu...
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial
To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction (TW) in treating patients with diabetic peripheral neuropathy (DPN).
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Article
Translation, cultural adaptation, and validation of the Chinese standardized outcomes in nephrology–hemodialysis fatigue (C-SONG–HD fatigue) scale: a study of Chinese patients undergoing hemodialysis
This study aimed to translate and culturally adapt the standardized outcomes in nephrology–hemodialysis fatigue (SONG–HD fatigue) scale and to assess the psychometric properties of the Chinese version of the S...
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Article
Open AccessChromosome-level genome provides insight into the evolution and conservation of the threatened goral (Naemorhedus goral)
Gorals Naemorhedus resemble both goats and antelopes, which prompts much debate about the intragenus species delimitation and phylogenetic status of the genus Naemorhedus within the subfamily Caprinae. Their evol...
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Article
Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain
Chronic pain often develops severe mood changes such as depression. However, how chronic pain leads to depression remains elusive and the mechanisms determining individuals’ responses to depression are largely...
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Article
Fungal diversity notes 1717–1817: taxonomic and phylogenetic contributions on genera and species of fungal taxa
As the continuation of Fungal Diversity Notes series, the current paper is the 16th contribution to this series. A total of 103 taxa from seven classes in Ascomycota and Basidiomycota are included here. Of these ...
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Book and Conference Proceedings
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Chapter and Conference Paper
Research and Application of Special Completion Technology in Complex Wellbore Conditions of Ultra-Deep Carbonate Reservoirs
The oil and gas resources over 6000 m in Tarim Basin account for 83.2% and 63.9% of the total oil and gas resources in China’s ultra-deep reservoirs respectively, and the prospect of exploration and developmen...
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Chapter and Conference Paper
Preliminary Study on Oil Test and Completion Technology of Over 9000 m Deep Wells—Taking Guole X Well as an Example
In recent years, the exploration and development of Tarim Basin has been develo** in the vertical direction, and the oil and gas in deep and ultra-deep depths has gradually increased from 8000 m to 9000 m. T...
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Chapter and Conference Paper
Irreducible Water Saturation Determination and Fluid Identification Methods in Carbonate Reservoirs: A Middle Eastern Case Study
In the H oilfield, there are many technical challenges in the effective fluid identifications of carbonate reservoirs with complex pore structures and diversified reservoir spaces when water flooding problems ...
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Article
Open AccessNeoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...
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Article
Efficacy and safety of sacubitril/allisartan for the treatment of primary hypertension: a phase 2 randomized, double-blind study
This randomized, double-blind phase 2 study assessed the efficacy and safety of sacubitril/allisartan, an angiotensin receptor neprilysin inhibitor, compared with placebo in Chinese patients with mild to moder...
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Article
Inconsistent increasing of climate potential productivity resulting from global warming and land use transitions in the Dongting Lake Basin, from 2000 to 2020
In the face of global warming and increasing impervious surfaces, quantifying the change of climate potential productivity (CPP) is of great significance for the food production planning. Targeting the Dongtin...
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Article
Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails
The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses challenges to the effectiveness of neutralizing antibodies. Rational design of antibody cocktails is a re...
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Article
Open AccessEnhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics
Glioma stem cells (GSCs) are responsible for glioma recurrence and drug resistance, yet the mechanisms underlying their maintenance remains unclear. This study aimed to identify enhancer-controlled genes invol...
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Article
Open AccessSingle-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function
Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting in aggravated clinical outcomes. However, due to the substantial heterogeneity within septic patients, precise ind...
