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  1. Article

    Open Access

    Single-cell and spatial architecture of primary liver cancer

    Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity and heterogeneity among PLCs remains challenging. Here, usi...

    Pei-Yun Zhou, Cheng Zhou, Wei Gan, Zheng Tang, Bao-Ye Sun in Communications Biology (2023)

  2. No Access

    Article

    The role and mechanisms of microvascular damage in the ischemic myocardium

    Following myocardial ischemic injury, the most effective clinical intervention is timely restoration of blood perfusion to ischemic but viable myocardium to reduce irreversible myocardial necrosis, limit infar...

    Bang-Hao Zhao, Amanguli Ruze, Ling Zhao, Qiu-Lin Li in Cellular and Molecular Life Sciences (2023)

  3. Article

    Biomarkers of aging

    Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...

    Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen in Science China Life Sciences (2023)

  4. No Access

    Article

    QTL-seq and transcriptomic integrative analyses reveal two positively regulated genes that control the low-temperature germination ability of MTP–maize introgression lines

    Two candidate genes (ZmbZIP113 and ZmTSAH1) controlling low-temperature germination ability were identified by QTL-seq and integrative transcriptomic analyses. The functional verification results showed that t...

    Ru-Yu He, Jun-Jun Zheng, Yu Chen, Ze-Yang Pan, Tao Yang in Theoretical and Applied Genetics (2023)

  5. No Access

    Article

    ACC deaminase-encoding Pseudomonas putida arrests seed germination: an alternative strategy for grass and weed control

    A recent report indicated that 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase-encoding Pseudomonas aeruginosa inhibited Arabidopsis germination. The aim of this study was to understand the role of ACC deam...

    Di Zhou, Jia-Ling Zhao, Rui Wang, Hai-Lin Wang in Plant and Soil (2022)

  6. Article

    Open Access

    Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha

    Ten new germacrane-type sesquiterpenoids, artemyrianosins A–J (110), were isolated from the aerial parts of Artemisia myriantha. Their structures were elucidated by spectral analyses including UV, IR, HRESIMS, 1...

    **n Zhang, Yun-Bao Ma, **ao-Feng He, Tian-Ze Li in Natural Products and Bioprospecting (2022)

  7. Article

    Open Access

    Comparative transcriptome and DNA methylation analysis in temperature-sensitive genic male sterile wheat BS366

    Known as the prerequisite component for the heterosis breeding system, the male sterile line determines the hybrid yield and seed purity. Therefore, a deep understanding of the mechanism and gene network that ...

    Yong-jie Liu, Dan Li, Jie Gong, Yong-bo Wang, Zhao-bo Chen, Bin-shuang Pang in BMC Genomics (2021)

  8. Article

    Open Access

    The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression

    It has been recently reported that CD38 expressed on tumor cells of multiple murine and human origins could be upregulated in response to PD-L1 antibody therapy, which led to dysfunction of tumor-infiltrating CD8

    Long Gao, Yuan Liu, **aohong Du, Sai Ma, Minmin Ge, Haijun Tang in Cell Death & Disease (2021)

  9. No Access

    Article

    Enhancing extracellular production of recombinant proteins in Escherichia coli by co-expressing with a haloarchaeal protein containing a putative LolA-like domain

    Escherichia coli represents one of the most widely used hosts for recombinant protein production, but its limited capacity for producing extracellular proteins is often cited as a drawback. NJ7G_0991 is an extrac...

    Jian Wang, Chuang Hao, Lei Cao, Yitong Yao in Applied Microbiology and Biotechnology (2021)

  10. Article

    Open Access

    Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling

    Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG.

    Zhen-**ong **, **n-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao in Stem Cell Research & Therapy (2021)

  11. Article

    Open Access

    Comparative transcriptomic analysis reveals female-biased olfactory genes potentially involved in plant volatile-mediated oviposition behavior of Bactrocera dorsalis

    Olfactory systems take on important tasks to distinguish salient information from a complex olfactory environment, such as locating hosts, mating, aggression, selecting oviposition sites, and avoiding predator...

    Li Xu, Kai-Yue Tang, **ao-Feng Chen, Yong Tao, Hong-Bo Jiang, **-Jun Wang in BMC Genomics (2021)

  12. Article

    Open Access

    Correction to: The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest

    An amendment to this paper has been published and can be accessed via the original article.

    Claude Rispe, Fabrice Legeai, Paul D. Nabity, Rosa Fernández in BMC Biology (2020)

  13. Article

    Open Access

    The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest

    Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on ...

    Claude Rispe, Fabrice Legeai, Paul D. Nabity, Rosa Fernández in BMC Biology (2020)

  14. Article

    Open Access

    RpfC regulates the expression of the key regulator hrpX of the hrp/T3SS system in Xanthomonas campestris pv. campestris

    The Gram-negative phytopathogenic bacterium Xanthomonas campestris pv. campestris recruits the hrp/T3SS system to inject pathogenicity effector proteins into host cells and uses the rpf/DSF cell-cell signaling sy...

    Bo-Le Jiang, Guo-Feng Jiang, Wei Liu, Li-Chao Yang, Li-Yan Yang in BMC Microbiology (2018)

  15. No Access

    Article

    Endophytic effects of Aspergillus oryzae on radish (Raphanus sativus) and its herbivore, Plutella xylostella

    We provide evidence that Aspergillus oryzae not only acts as an endophyte in Raphanus sativus, but also works as a plant growth promoter and provides some protection against its herbivore, Plutella xylostella aff...

    Bo-Tong Sun, Komivi Senyo Akutse, **ao-Feng **a, Jun-Hui Chen, **n Ai, Yang Tang in Planta (2018)

  16. No Access

    Article

    Autocatalytic activation of a thermostable glutamyl endopeptidase capable of hydrolyzing proteins at high temperatures

    Glutamyl endopeptidases (GSEs) specifically hydrolyze peptide bonds formed by α-carboxyl groups of Glu and Asp residues. We cloned the gene for a thermophilic GSE (designated TS-GSE) from Thermoactinomyces sp. CD...

    Feng Liu, Zhong-Shu Zhao, Yuxia Ren, Guyue Cheng in Applied Microbiology and Biotechnology (2016)

  17. No Access

    Article

    A high-efficiency Agrobacterium tumefaciens mediated transformation system using cotyledonary node as explants in soybean (Glycine max L.)

    A high-efficiency Agrobacterium tumefaciens mediated transformation system was established through testing and optimising a range of variables using soybean cotyledonary as explants and glufosinate as selective a...

    **ao-feng Yang, **ao-qian Yu, Zheng Zhou, Wu-Jun Ma in Acta Physiologiae Plantarum (2016)

  18. No Access

    Article

    Physiological and proteomic analysis in two wild tomato lines under waterlogging and high temperature stress

    Tomato yields are reduced under waterlogging and high temperature stress condition. Ascorbic acid (ASA) was shown to be involved in tolerance to waterlogging and heat stresses in tomato. Among 44 wild tomato l...

    Hsin-Hung Lin, Kuan-Hung Lin, Jia-Yu Syu in Journal of Plant Biochemistry and Biotechn… (2016)

  19. No Access

    Article

    Degradation of intact chicken feathers by Thermoactinomyces sp. CDF and characterization of its keratinolytic protease

    Thermoactinomyces is known for its resistance to extreme environmental conditions and its ability to digest a wide range of hard-to-degrade compounds. Here, Thermoactinomyces sp. strain CDF isola...

    Liyuan Wang, Guyue Cheng, Yuxia Ren, Zheng Dai in Applied Microbiology and Biotechnology (2015)

  20. No Access

    Article

    ABI-like transcription factor gene TaABL1 from wheat improves multiple abiotic stress tolerances in transgenic plants

    The phytohormone abscisic acid (ABA) plays crucial roles in adaptive responses of plants to abiotic stresses. ABA-responsive element binding proteins (AREBs) are basic leucine zipper transcription factors that...

    Dong-Bei Xu, Shi-Qing Gao, You-Zhi Ma, Zhao-Shi Xu in Functional & Integrative Genomics (2014)

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