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Article
Open AccessSingle-cell and spatial architecture of primary liver cancer
Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity and heterogeneity among PLCs remains challenging. Here, usi...
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Article
The role and mechanisms of microvascular damage in the ischemic myocardium
Following myocardial ischemic injury, the most effective clinical intervention is timely restoration of blood perfusion to ischemic but viable myocardium to reduce irreversible myocardial necrosis, limit infar...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
QTL-seq and transcriptomic integrative analyses reveal two positively regulated genes that control the low-temperature germination ability of MTP–maize introgression lines
Two candidate genes (ZmbZIP113 and ZmTSAH1) controlling low-temperature germination ability were identified by QTL-seq and integrative transcriptomic analyses. The functional verification results showed that t...
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Article
ACC deaminase-encoding Pseudomonas putida arrests seed germination: an alternative strategy for grass and weed control
A recent report indicated that 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase-encoding Pseudomonas aeruginosa inhibited Arabidopsis germination. The aim of this study was to understand the role of ACC deam...
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Article
Open AccessArtemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha
Ten new germacrane-type sesquiterpenoids, artemyrianosins A–J (1–10), were isolated from the aerial parts of Artemisia myriantha. Their structures were elucidated by spectral analyses including UV, IR, HRESIMS, 1...
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Article
Open AccessComparative transcriptome and DNA methylation analysis in temperature-sensitive genic male sterile wheat BS366
Known as the prerequisite component for the heterosis breeding system, the male sterile line determines the hybrid yield and seed purity. Therefore, a deep understanding of the mechanism and gene network that ...
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Article
Open AccessThe intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression
It has been recently reported that CD38 expressed on tumor cells of multiple murine and human origins could be upregulated in response to PD-L1 antibody therapy, which led to dysfunction of tumor-infiltrating CD8
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Article
Enhancing extracellular production of recombinant proteins in Escherichia coli by co-expressing with a haloarchaeal protein containing a putative LolA-like domain
Escherichia coli represents one of the most widely used hosts for recombinant protein production, but its limited capacity for producing extracellular proteins is often cited as a drawback. NJ7G_0991 is an extrac...
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Article
Open AccessOsthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling
Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG.
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Open AccessComparative transcriptomic analysis reveals female-biased olfactory genes potentially involved in plant volatile-mediated oviposition behavior of Bactrocera dorsalis
Olfactory systems take on important tasks to distinguish salient information from a complex olfactory environment, such as locating hosts, mating, aggression, selecting oviposition sites, and avoiding predator...
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Article
Open AccessCorrection to: The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest
An amendment to this paper has been published and can be accessed via the original article.
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Open AccessThe genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest
Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on ...
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Article
Open AccessRpfC regulates the expression of the key regulator hrpX of the hrp/T3SS system in Xanthomonas campestris pv. campestris
The Gram-negative phytopathogenic bacterium Xanthomonas campestris pv. campestris recruits the hrp/T3SS system to inject pathogenicity effector proteins into host cells and uses the rpf/DSF cell-cell signaling sy...
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Article
Endophytic effects of Aspergillus oryzae on radish (Raphanus sativus) and its herbivore, Plutella xylostella
We provide evidence that Aspergillus oryzae not only acts as an endophyte in Raphanus sativus, but also works as a plant growth promoter and provides some protection against its herbivore, Plutella xylostella aff...
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Article
Autocatalytic activation of a thermostable glutamyl endopeptidase capable of hydrolyzing proteins at high temperatures
Glutamyl endopeptidases (GSEs) specifically hydrolyze peptide bonds formed by α-carboxyl groups of Glu and Asp residues. We cloned the gene for a thermophilic GSE (designated TS-GSE) from Thermoactinomyces sp. CD...
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Article
A high-efficiency Agrobacterium tumefaciens mediated transformation system using cotyledonary node as explants in soybean (Glycine max L.)
A high-efficiency Agrobacterium tumefaciens mediated transformation system was established through testing and optimising a range of variables using soybean cotyledonary as explants and glufosinate as selective a...
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Article
Physiological and proteomic analysis in two wild tomato lines under waterlogging and high temperature stress
Tomato yields are reduced under waterlogging and high temperature stress condition. Ascorbic acid (ASA) was shown to be involved in tolerance to waterlogging and heat stresses in tomato. Among 44 wild tomato l...
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Article
Degradation of intact chicken feathers by Thermoactinomyces sp. CDF and characterization of its keratinolytic protease
Thermoactinomyces is known for its resistance to extreme environmental conditions and its ability to digest a wide range of hard-to-degrade compounds. Here, Thermoactinomyces sp. strain CDF isola...
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ABI-like transcription factor gene TaABL1 from wheat improves multiple abiotic stress tolerances in transgenic plants
The phytohormone abscisic acid (ABA) plays crucial roles in adaptive responses of plants to abiotic stresses. ABA-responsive element binding proteins (AREBs) are basic leucine zipper transcription factors that...