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Article
Open AccessNT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma
Most hepatocellular carcinoma (HCC) patients are diagnosed at an advanced stage; however, the effect of systemic therapy on advanced HCC remains undetermined. Therefore, new treatment targets must be identifie...
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Article
Open AccessUSP49 participates in the DNA damage response by forming a positive feedback loop with p53
The p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB)...
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Article
Open AccessPFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key molecule of glucose metabolism in cytoplasm, has been found in various tumors. Emerging evidence has suggested that PFKFB...
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