-
Article
Open AccessEZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby EZH2 promotes cancer....
-
Article
Porous organic polymer/MMT hybrid supports for efficient metallocene catalysts
The preparation of organic/inorganic hybrid materials has been proven to be an effective method to overcome the drawbacks of organic or inorganic materials. In this paper, porous organic polymer/montmorillonit...
-
Article
USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression
Tumor cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation. How these metabolic processes are integrated to fuel cancer cell growth remains largely unknown. Deciph...
-
Article
Open AccessInvestigation of anti-osteoporosis mechanisms of Rehmanniae Radix Preparata based on network pharmacology and experimental verification
Rehmanniae Radix Preparata (RRP) can effectively improve the symptoms of osteoporosis, but its molecular mechanism for treating osteoporosis is still unclear. The objective of this study is to investigate the ant...
-
Article
Open AccessUSP49 participates in the DNA damage response by forming a positive feedback loop with p53
The p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB)...
