21 Result(s)

Article

The Shigella kinase effector OspG modulates host ubiquitin signaling to escape septin-cage entrapment

Shigella flexneri is a Gram-negative bacterium causing severe bloody dysentery. Its pathogenesis is largely dictated by a plasmid-encoded type III secretion system (T3SS) and its associated effectors. Among these...

Wei **an, Jiaqi Fu, Qinxin Zhang, Chuang Li, Yan-Bo Zhao… in Nature Communications (2024)

Article

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major fa...

Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li… in Nature Communications (2024)

Article

Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential

Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection a...

**g Wang, Yuan-fei Pan, Li-fen Yang, Wei-hong Yang, Kexin Lv… in Nature Communications (2023)

Article

Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila

Toxin-antitoxin (TA) systems are ubiquitous genetic modules in bacteria and archaea. Here, we perform structural and biochemical characterization of the Legionella pneumophila effector Lpg2370, demonstrating that...

**angkai Zhen, Yongyu Wu, **li Ge, Jiaqi Fu, Le Ye, Niannian Lin… in Nature Communications (2022)

Article

Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular calcificati...

Zhen-**ng Wang, Zhong-Wei Luo, Fu-**ng-Zi Li, Jia Cao… in Nature Communications (2022)

Article

A bacterial kinase phosphorylates OSK1 to suppress stomatal immunity in rice

The Xanthomonas outer protein C2 (XopC2) family of bacterial effectors is widely found in plant pathogens and Legionella species. However, the biochemical activity and host targets of these effectors remain enigm...

Shanzhi Wang, Shuai Li, Jiyang Wang, Qian Li, … in Nature Communications (2021)

Article

Author Correction: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

Huan Lian, ** Wei, Ru Zang, Wen Ye, Qing Yang, **a-Nan Zhang… in Nature Communications (2021)

Article

Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes

Autoinducer-2 (AI-2) is a quorum sensing signal that mediates communication within and between many bacterial species. However, its known receptors (LuxP and LsrB families) are not found in all the bacteria ca...

Lei Zhang, Shuyu Li, **aozhen Liu, Zhuo Wang, Mei Jiang… in Nature Communications (2020)

Article

Author Correction: The Apostasia genome and the evolution of orchids

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Guo-Qiang Zhang, Ke-Wei Liu, Zhen Li, Rolf Lohaus, Yu-Yun Hsiao, Shan-Ce Niu… in Nature (2020)

Article

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

The bacterial effector MavC modulates the host immune response by blocking Ube2N activity employing an E1-independent ubiquitin ligation, catalyzing formation of a γ-glutamyl-ε-Lys (Gln40^Ub-Lys92^Ube2N) isopeptide...

Kedar Puvar, Shalini Iyer, Jiaqi Fu, Sebastian Kenny… in Nature Communications (2020)

Article

Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC

Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in eukaryotic cells. Recently, the Legionella effector MavC was found to mediate a unique ...

Yajuan Mu, Yue Wang, Yanfei Huang, Dong Li, Youyou Han, Min Chang… in Nature Communications (2020)

Article

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

Cyclic GMP-AMP synthase (cGAS) senses double-strand (ds) DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the adaptor MITA/STING to initiate innate antiviral respo...

Huan Lian, ** Wei, Ru Zang, Wen Ye, Qing Yang, **a-Nan Zhang… in Nature Communications (2018)

Article

Spectral features of the tunneling-induced transparency and the Autler-Townes doublet and triplet in a triple quantum dot

We theoretically investigate the spectral features of tunneling-induced transparency (TIT) and Autler-Townes (AT) doublet and triplet in a triple-quantum-dot system. By analyzing the eigenenergy spectrum of th...

**ao-Qing Luo, Zeng-Zhao Li, Jun **g, Wei **ong, Tie-Fu Li, Ting Yu in Scientific Reports (2018)

Article

Dynamic profile of differentiated thyroid cancer in male and female patients with thyroidectomy during 2000–2013 in China: a retrospective study

The study aimed to investigate the gender-related differences of disease onset, age distribution, blood type, clinical characteristics, and malignant behaviors of differentiated thyroid carcinoma (DTC) in Chin...

Hui-xian Yan, ** Pang, Fu-lin Wang, Wen Tian, Yu-kun Luo, Wei Huang… in Scientific Reports (2017)

Article

Observation of the exceptional point in cavity magnon-polaritons

Magnon–polaritons are hybrid light–matter quasiparticles originating from the strong coupling between magnons and photons. They have emerged as a potential candidate for implementing quantum transducers and me...

Dengke Zhang, **ao-Qing Luo, Yi-Pu Wang, Tie-Fu Li, J. Q. You in Nature Communications (2017)

Article

The Apostasia genome and the evolution of orchids

WebComparing the whole genome sequence of Apostasia shenzhenica with transcriptome and genome data from five orchid subfamilies permits the reconstruction of an ancestral gene toolkit, providing insight into orch...

Guo-Qiang Zhang, Ke-Wei Liu, Zhen Li, Rolf Lohaus, Yu-Yun Hsiao, Shan-Ce Niu… in Nature (2017)

Article

A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition

Iron sequestration by host proteins contributes to the defence against bacterial pathogens, which need iron for their metabolism and virulence. A Pseudomonas aeruginosa mutant lacking all three known iron acquisi...

**shui Lin, Weipeng Zhang, Juanli Cheng, Xu Yang, Kaixiang Zhu… in Nature Communications (2017)

Article

A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer

Forty-nine patients with stage II_b cervical cancer were included to investigate the changes in bladder volume in response to different approaches to maintaining consistent bladder filling. The impacts of age (P ...

Fu **, Huan-Li Luo, Juan Zhou, Ding-Yi Yang, Li Yin, **ao-Qing Yang… in Scientific Reports (2017)

Article

Integrated photonics with programmable non-volatile memory

Silicon photonics integrated circuits (Si-PIC) with well-established active and passive building elements are progressing towards large-scale commercialization in optical communications and high speed optical ...

Jun-Feng Song, **an-Shu Luo, Andy Eu-** Lim, Chao Li, Qing Fang… in Scientific Reports (2016)

Article

SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril) -Induced Cough: a Pharmacogenetic Study

Clinical observations suggest that incidence of cough in Chinese taking angiotensin converting enzyme inhibitors is much higher than other racial groups. Cough is the most common adverse reaction of enalapril....

Jian-Quan Luo, Fa-Zhong He, Zhen-Min Wang, Ning-Ling Sun, Lu-Yan Wang… in Scientific Reports (2015)