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Article
Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families
To examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype deficiency.
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Article
Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke: Insights from Network Pharmacology and in vivo Experiments
To explore the neuroprotective effects and mechanism of Tanreqing Injection (TRQ) on treating ischemic stroke based on network pharmacology and in vivo experimental validation.
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Article
Open AccessCorrection: Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease
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Article
Open AccessTwo Decades of Publications in Journals Dedicated to Autoimmunity: A Bibliometric Analysis of the Autoimmunity Field from 2004 to 2023
To carry out an in-depth analysis of the scientific research on autoimmunity, we performed the first bibliometric analysis focusing on publications in journals dedicated to autoimmunity (JDTA) indexed by scien...
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Article
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass ...
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Article
Two New Anti-SARS-CoV-2 Naphthoquinones from Cigar-Tobacco-Derived Endophytic Fusarium oxysporum
In this study, two new naphthoquinones, 6-isopropyl-7-methoxy-2-(2-oxopropyl)naphthalene-1,4-dione (1) and 7-hydroxy-6-isopropyl-2-(2-oxopropyl)naphthalene-1,4-dione (2), together with five known new naphthoquino...
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Article
Bioactivity Isochromenes from Cigar Tobacco-Derived Endophytic Fungus Aspergillus fumigatus
Two new isochromenes, 1-(8-methoxy-3-methyl-1H-isochromen-6-yl)propan-1-one (1) and 3-hydroxy-1-(8- methoxy-3-methyl-1H-isochromen-7-yl)propan-1-one (2), along with five known ones, (3–7) were isolated from the f...
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Article
Chromium stabilization by polysulfide supported nZVI@biochar in contaminated soil: Cr bioavailability and stabilization mechanism
Chromium (Cr) contamination in soil is one of the most severe environmental issues, which poses significant health hazards to humans. In this study, the stabilization mechanism of Cr-contaminated soil by polys...
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Article
Detection of Novel BEST1 Variations in Autosomal Recessive Bestrophinopathy Using Third-generation Sequencing
Autosomal recessive bestrophinopathy (ARB), a retinal degenerative disease, is characterized by central visual loss, yellowish multifocal diffuse subretinal deposits, and a dramatic decrease in the light peak ...
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Article
A Dietary Supplement **ghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides
To determine the possible protective effects of **ghuosu, a dietary supplement (DS), on tripterygium glycosides (TG)-induced reproductive system injury in rats and its underlying mechanisms.
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Article
Open AccessAssembly and characterization of the complete mitochondrial genome of Descurainia sophia: a medical plant producing glucosinolate
As a commonly used traditional Chinese medicine, Descurainia sophia has various reported pharmacological activities such as prevention of chronic diseases, cardiovascular protection, neuroprotection, anticancer, ...
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Article
Effect of preform structure on mechanical and thermal properties of SiCf/SiC composites
In this paper, SiCf/SiC composites with three kinds of preform structures, namely 2D multilayered, 3D angle-interlock and multiaxis 3D braided, were prepared by chemical vapor infiltration. The influences of pref...
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Article
Two New Antibacterial Naphthoquinones from a Cigar Tobacco-Derived Endophytic Fusarium solani
In this study, two new (1 and 2), together with five known (3–7) naphthoquinones were isolated from the cigar tobacco-derived endophytic Fusarium solani. Their structures were determined by means of HR-ESI-MS and...
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Article
Open AccessPrenylated flavonoids isolated from the twigs of Artocarpus champeden as potential activators for tobacco powdery mildew and their mode of actions
Golovinomyces cichoracearum (DC.) is the main pathogen for tobacco powdery mildew fungus disease. Its outbreaks often result in severe harvest losses for the yield and quality of tobacco. Artocarpus champeden is ...
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Article
Open AccessBRD4770 inhibits vascular smooth muscle cell proliferation via SUV39H2, but not EHMT2 to protect against neointima formation
The behavior of vascular smooth muscle cells (VSMCs) contributes to the formation of neointima. We previously found that EHMT2 suppressed autophagy activation in VSMCs. BRD4770, an inhibitor of EHMT2/G9a, play...
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Article
Open Access3D simulation of percutaneous sustentaculum tali screw insertion in calcaneal fractures
In calcaneal fractures, the percutaneous screw fixation (PSF) is currently considered to be the better choice, but it is difficult to accurately place the screw into the sustentaculum tali (ST) during the oper...
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Article
Antiviral Chromone Alkaloids from the Cigar Tobacco Leaves Derived Endophytic Fungus Aspergillus lentulus
The chromone alkaloids have attracted the widespread attention of chemists and biologists due to their complex structures and prominent bioactivities. With the aim of screening more antiviral activity metaboli...
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Article
Open AccessThe shock, the co**, the resilience: smartphone application use reveals Covid-19 lockdown effects on human behaviors
Human mobility restriction policies have been widely used to contain the coronavirus disease-19 (COVID-19). However, a critical question is how these policies affect individuals’ behavioral and psychological w...
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Article
Open AccessIntegrative multi-omics analysis depicts the methylome and hydroxymethylome in recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression
Urinary bladder cancer (UBC) is a common malignancy of the urinary tract; however, the mechanism underlying its high recurrence and responses to immunotherapy remains unclear, making clinical outcome predictio...
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Article
CircMAN1A2 contributes to nasopharyngeal carcinoma progression via enhancing the ubiquitination of ATMIN through miR-135a-3p/UBR5 axis
Recently, the dysregulation of circRNAs has been increasingly implicated in the pathogenesis of nasopharyngeal carcinoma (NPC). Among these circRNAs, circMAN1A2 has been highlighted for the up-regulated expres...
