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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Open AccessPhylodynamics unveils invading and diffusing patterns of dengue virus serotype-1 in Guangdong, China from 1990 to 2019 under a global genoty** framework
The strong invasiveness and rapid expansion of dengue virus (DENV) pose a great challenge to global public health. However, dengue epidemic patterns and mechanisms at a genetic scale, particularly in term of c...
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Soil moisture drives the shift from selection to complementarity effect in the rainfed maize/faba bean intercrop** system
Selection effect (SE) and complementarity effect (CE) are often considered as two key indicators to mediate the positive diversity-productivity relationship in the maize-legume intercrop** system, as intercr...
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Open AccessOsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate
The chromatin modifier GRAIN WEIGHT 6a (GW6a) enhances rice grain size and yield. However, little is known about its gene network determining grain size. Here, we report that MITOGEN-ACTIVED PROTEIN KINASE 6 (...
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Supramolecular systems for bioapplications: recent research progress in China
Supramolecular systems feature dynamic, reversible and stimuli-responsive characteristics, which are not easily achieved by molecular entities. The last decade has witnessed tremendous advances in the investig...
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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating e...
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Effect of Cinnamaldehyde on Systemic Candida albicans Infection in Mice
To investigate the therapeutic efficacy of cinnamaldehyde (CA) on systemic Candida albicans infection in mice and to provide supportive data for the development of novel antifungal drugs.
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Characterization of soil heavy metals at an abandoned smelting site based on particle size fraction and its implications for remediation strategy
Soil particle size plays a crucial role in the distribution and occurrence of soil heavy metals (HMs). Comparative studies on the distribution of HMs across soil particle sizes of various areas affected by sme...
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Structure of GPR101–Gs enables identification of ligands with rejuvenating potential
GPR101 is an orphan G protein-coupled receptor actively participating in energy homeostasis. Here we report the cryo-electron microscopy structure of GPR101 constitutively coupled to Gs heterotrimer, which rev...
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Open AccessCD4+CD25+ regulatory T cells ex vivo generated from autologous naïve CD4+ T cells suppress EAE progression
CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining immune homeostasis in multiple sclerosis (MS). Hence, we aimed to explore the therapeutic efficacy and safety of adoptive cell therapy (A...
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TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling
Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast Asia. Metastasis of NPC remains the main cause of death for ...
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Open AccessModelling the dynamic basic reproduction number of dengue based on MOI of Aedes albopictus derived from a multi-site field investigation in Guangzhou, a subtropical region
More than half of the global population lives in areas at risk of dengue (DENV) transmission. Develo** an efficient risk prediction system can help curb dengue outbreaks, but multiple variables, including mo...
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Open AccessMagnaporthe oryzae effector AvrPik-D targets a transcription factor WG7 to suppress rice immunity
Rice blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the most devastating diseases for rice crops, significantly affecting crop yield and quality. During the infection process, M. oryzae secret...
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Open AccessDysfunction of duplicated pair rice histone acetyltransferases causes segregation distortion and an interspecific reproductive barrier
Postzygotic reproductive isolation, which results in the irreversible divergence of species, is commonly accompanied by hybrid sterility, necrosis/weakness, or lethality in the F1 or other offspring generations. ...
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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n
Nondestructive and noninvasive neutron assays are essential applications of neutron techniques. Neutron resonance transmission analysis (NRTA) is a powerful nondestructive method for investigating the elementa...
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Icariin ameliorates the cuprizone-induced demyelination associated with antioxidation and anti-inflammation
The treatment of immunomodulation in multiple sclerosis (MS) can alleviate the severity and relapses. However, it cannot improve the neurological disability of patients due to a lack of myelin protection and r...
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Vortex identification based on the Liutex method and its effect on fish passage upstream
Fishway research is important for mitigating the fragmentation of river habitats caused by hydraulic projects. The vertical slit fishway is a broadly used fishway type because of its high efficiency and adapta...
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Fungal diversity notes 1717–1817: taxonomic and phylogenetic contributions on genera and species of fungal taxa
As the continuation of Fungal Diversity Notes series, the current paper is the 16th contribution to this series. A total of 103 taxa from seven classes in Ascomycota and Basidiomycota are included here. Of these ...
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Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation
DNA cytosine methylation plays a vital role in repressing retrotransposons, and such derepression is linked with developmental failure, tumorigenesis and aging. DNA methylation patterns are formed by precisely...
