21 Result(s)
within
**ao-Feng Gong
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAssociation between serum 25-hydroxyvitamin D and fasting blood glucose in osteoporosis patients
Osteoporosis (OP) is often associated with other complications, such as impaired glucose homeostasis. Vitamin D deficiency is common and has been linked to bone metabolism and the regulation of blood sugar lev...
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Article
Open AccessA longitudinal resource for population neuroscience of school-age children and adolescents in China
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...
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Open AccessSerum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model
Ménière’s disease, a multifactorial disorder of the inner ear, is characterized by severe vertigo episodes and hearing loss. Although the role of immune responses in Ménière’s disease has been proposed, the pr...
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Article
Open AccessSynergistic promotions between CO2 capture and in-situ conversion on Ni-CaO composite catalyst
The integrated CO2 capture and conversion (iCCC) technology has been booming as a promising cost-effective approach for Carbon Neutrality. However, the lack of the long-sought molecular consensus about the synerg...
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Article
Open AccessGrowth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma
Tumour lineage plasticity is an emerging hallmark of aggressive tumours. Tumour cells usually hijack developmental signalling pathways to gain cellular plasticity and evade therapeutic targeting. In the presen...
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Article
Open AccessSynthesized soliton crystals
Dissipative Kerr soliton (DKS) featuring broadband coherent frequency comb with compact size and low power consumption, provides an unparalleled tool for nonlinear physics investigation and precise measurement...
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Article
Open AccessFUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer
Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein. Howe...
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Open Access1/f-noise-free optical sensing with an integrated heterodyne interferometer
Optical evanescent sensors can non-invasively detect unlabeled nanoscale objects in real time with unprecedented sensitivity, enabling a variety of advances in fundamental physics and biological applications. ...
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Open AccessMachine learning based early warning system enables accurate mortality risk prediction for COVID-19
Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. ...
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Article
Open AccessA noise-resisted scheme of dynamical decoupling pulses for quantum memories
Stable quantum memories that capable of storing quantum information for long time scales are an essential building block for an array of potential applications. The long memory time are usually achieved via dy...
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Open AccessAutophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease geneti...
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Open AccessDevelopment of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characteriza...
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Article
Open AccessCaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
Autophagy is a degradative pathway that delivers cellular components to the lysosome for degradation. The role of autophagy in cell differentiation is poorly understood. Here we show that CaMKII can directly p...
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Article
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes
A mutation that increases the secretion of Zika virus non-structural protein 1 (NS1) in infected hosts enhances the ability of the virus to infect its mosquito vector Aedes aegypti and might have contributed to t...
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Article
Open AccessNear-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability
Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths each year in Asia. The structural and molecular ba...
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Article
Open AccessSIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity
The homeodomain transcription factor Nkx2.5/Csx is critically essential for heart specification, morphogenesis, and homeostasis. Acetylation/deacetylation is important for the localization, stability and activ...
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Article
Open AccessRegulation of T cell function by microRNA-720
Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit a...
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Article
Open AccessAcetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth
Beclin 1, a protein essential for autophagy, regulates autophagy by interacting with Vps34 and other cofactors to form the Beclin 1 complex. Modifications of Beclin 1 may lead to the induction, inhibition or f...
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Article
Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2–macroH2A1 (mH...
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Open AccessRegulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection
T cell functional exhaustion during chronic hepatitis B virus (HBV) infection may contribute to the failed viral clearance; however, the underlying molecular mechanisms remain largely unknown. Here we demonstr...
