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Open AccessPrognostic analysis of rectal cancer patients after neoadjuvant chemoradiotherapy: different prognostic factors in patients with different TRGs
The extent of tumor regression varies widely among locally advanced rectal cancer (LARC) patients who receive neoadjuvant chemoradiotherapy (NCRT) followed by total mesorectal excision (TME). The purpose of th...
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Article
PRDX1 Interfering Peptide Disrupts Amino Acids 70–90 of PRDX1 to Inhibit the TLR4/NF-κB Signaling Pathway and Attenuate Neuroinflammation and Ischemic Brain Injury
Ischemic stroke ranks among the leading causes of death and disability in humans and is accompanied by motor and cognitive impairment. However, the precise mechanisms underlying injury after stroke and effecti...
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Article
A Higher Stomatal Aperture is Associated with the Growth Promotion of Centipedegrass (Eremochloa ophiuroides (Munro) Hack.) Under High Concentrations of Ammonium
The key to improving the efficiency by which acid-soil-growing plants utilize nitrogen is to improve their efficiency of utilizing ammonium. The carbon deficiency is recognized as the main cause of the failure...
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Article
Secondary Metabolites of Chaetomium angustispirale
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Article
Effects of Three Emerging Non-thermal Pretreatments on Drying Kinetics, Physicochemical Quality, and Microstructure of Garlic Slices
Three emerging non-thermal pretreatment methods, including cold plasma, ultrasound, and ozone water, were utilized to pretreat garlic slices before drying process. The garlic slices were then dried by hot air ...
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Article
Open AccessNanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer
Nanocarrier delivery of small interfering RNAs (siRNAs) to silence cancer-associated genes is a promising method for cancer treatment. Here, we explored the role and mechanisms of PLAG NPs-delivered si-Notch1 ...
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Article
Effect of Artificial Cooling Extrusion on Microstructure and Mechanical Properties of Mg–Zn–Y Alloys
Microstructure and mechanical properties of Mg–Zn–Y alloys with different Zn/Y atomic ratios with or without artificial cooling (AC) extrusion were systematically investigated in this work. The results show th...
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Article
Open AccessEngineering Escherichia coli for high-yielding 2,5-Dimethylpyrazine synthesis from L-Threonine by reconstructing metabolic pathways and enhancing cofactors regeneration
2,5-Dimethylpyrazine (2,5-DMP) is important pharmaceutical raw material and food flavoring agent. Recently, engineering microbes to produce 2,5-DMP has become an attractive alternative to chemical synthesis ap...
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Article
Open AccessEfficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis
This study aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) for infertility and recurrent spontaneous abortion.
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Article
Multifunctional Ti3C2Tx MXene/montmorillonite/cellulose nanofibril films for electromagnetic interference shielding, photothermal conversion, and thermal insulation
Multifunctional electromagnetic interference (EMI) shielding composite films with thermal insulation and photothermal conversion properties are urgently needed for microelectronic devices, especially in extrem...
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Article
Open AccessAuthor Correction: Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma
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Article
Multifunctional MXene-decorated cotton fabric with different weaves, outstanding photothermal effect, and rapid response
The cotton fabric materials have gained widespread attention on account of their tailorable shape, flexible deformable, and lightweight in recent years. Nevertheless, there are still certain challenges in fabr...
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Article
Fabrication and Properties of Mo2FeB2 Cermet Coating on Stainless Steel Surface via One-Step Forming Technology of Powder Metallurgy
Mo2FeB2 cermet coating and stainless steel substrate were integrally fabricated by one-step forming technology of powder metallurgy. The phase and microstructure of the coating and interface were analysed through...
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Article
Efficacy and safety of anti-PD-1 inhibitor combined with nab-paclitaxel in Chinese patients with refractory melanoma
This retrospective study aimed to evaluate the combined effect of anti-PD-1 inhibitor and nanoparticle albumin-bound (nab)-paclitaxel for refractory melanoma among Chinese patients.
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Article
Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling
Vascular calcification (VC) is characterized by pathological depositions of calcium and phosphate in the arteries and veins via an active cell-regulated process, in which vascular smooth muscle cells (VSMCs) t...
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Open AccessDocking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B
Glycosyltransferases typically display acceptor substrate flexibility but more stringent donor specificity. BsGT-1 is a highly effective glycosyltransferase to glycosylate macrolides, including epothilones, pr...
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Article
Open AccessSedentary lifestyle and body composition in type 2 diabetes
Body composition alterations may participate in the pathophysiological processes of type 2 diabetes (T2D). A sedentary lifestyle may be responsible for alterations of body composition and adverse consequences,...
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Open AccessAssociation of sleep quality with glycemic variability assessed by flash glucose monitoring in patients with type 2 diabetes
Deterioration of sleep quality has been reported to contribute to the incidence of diabetes and may be responsible for glycemic status in diabetes. The present study explored the relationship between sleep qua...
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Open AccessDetection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial
It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...
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Open AccessSARS-CoV-2: vaccines in the pandemic era
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As ...
