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Article
Open AccessA glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation
Coronaviruses employ various strategies for survival, among which the activation of endogenous or exogenous apoptosis stands out, with viral proteins playing a pivotal role. Notably, highly pathogenic coronavi...
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Article
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...
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Article
Prevalent landscape of tumor genomic alterations of luminal B1 breast cancers using a comprehensive genomic profiling assay in Taiwan
The human epidermal growth factor receptor 2 (HER2) negative luminal B1 subtype of breast cancer has been reported with a poorer outcome than luminal A in recent studies. This study aimed to investigate the mo...
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Article
Tuning the Properties of Bio-based Thermoplastic Polyurethane Derived from Polylactic Acid by Varying Chain Extenders and Hard Segment Contents
Currently, the preparation and application of bio-based thermoplastic polyurethane (TPU) are hot research topics in the field of polyurethane. In the present work, a series of polylactic acid (PLA)-based TPUs ...
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Chapter and Conference Paper
From the Perspective of High-Risk Leisure Environment: A Study of the Impact of Green Education Literacy on River Water, Ecology, Surrounding Rural Economic Development, and Youth Well-Being
This study aims to discuss the impact of green education literacy on lake water, rural economic development, and youth well-being in a high-risk leisure environment. A mixed methods approach was adopted. First...
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Chapter and Conference Paper
Experimental Study on Enhanced Oil Recovery by Microbial Chemical Flooding in High Pour Point Oil Reservoir
High pouching oil is characterized by high freezing point, high wax content and high wax extraction temperature. During the development process, the oil reservoir is prone to wax precipitation, forming cold da...
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Measurement of Br(n,γ) cross sections up to stellar s-process temperatures at the CSNS Back-n
The neutron capture cross sections ( \({n,\gamma }\) n , ...
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Article
Open AccessID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer
Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the prominant population of immune ce...
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Article
Open AccessSingle-cell and spatial architecture of primary liver cancer
Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity and heterogeneity among PLCs remains challenging. Here, usi...
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Article
Clinical characteristics and treatment outcomes of invasive ductal and lobular carcinoma: analyses of 54,832 taiwan cancer registry index cases
Invasive lobular cancer (ILC) is the second most common histology type of breast cancer followed by invasive ductal carcinoma (IDC). This study aimed to investigate the characteristic, treatment strategies, an...
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Article
Functional screening and rational design of compounds targeting GPR132 to treat diabetes
Chronic inflammation due to islet-residing macrophages plays key roles in the development of type 2 diabetes mellitus. By systematically profiling intra-islet lipid–transmembrane receptor signalling in islet-r...
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Article
Flat-leaf submerged plants are more sensitive to invasion intensity and water nutrition levels than needle-leaf ones
Plant invasion and water eutrophication severely damage wetland plant growth. However, the effects of plant invasion and water nutrient levels on the growth of submerged plants with different leaf types remain...
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Article
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition
Suprachiasmatic nucleus (SCN) in mammals functions as the master circadian pacemaker that coordinates temporal organization of physiological processes with the environmental light/dark cycles. But the causativ...
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Article
Open AccessThe STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay
Ischemic stroke is a leading cause of global mortality and long-term disability. However, there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in limited knowledge of the interpl...
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Article
Open AccessEffect of a novel telehealth device for dietary cognitive behavioral intervention in overweight or obesity care
Obesity has become a major public health issue which relate to numerous physical problems and highly comorbid with depression and anxiety. Recently, some studies of technology-based interventions for weight re...
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Article
Treatment of Irritable Bowel Syndrome by Chinese Medicine: A Review
Irritable bowel syndrome (IBS) is a common refractory disease. Chinese medicine (CM) has remarkable efficacy and advantages on the treatment of IBS. This review summarized the articles focusing on the treatmen...
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Article
IiSVP of Isatis indigotica can reduce the size and repress the development of floral organs
IiSVP of Isatis indigotica was cloned and its expression pattern was analyzed. Ectopic expression of IiSVP in Arabidopsis could delay the flowering time and reduce the size of the floral organs.
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Article
Open AccessExosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation
The activation of the complement system and subsequent inflammatory responses are important features of myocardial ischemia/reperfusion (I/R) injury. Exosomes are nanoscale extracellular vesicles that play a s...
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Article
Static superconducting gantry-based proton CT combined with X-ray CT as prior image for FLASH proton therapy
Proton FLASH therapy with an ultra-high dose rate is in urgent need of more accurate treatment plan system (TPS) to promote the development of proton computed tomography (CT) without intrinsic error compared w...
