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Open AccessDeep learning model for the prediction of all-cause mortality among long term care people in China: a prospective cohort study
This study aimed to develop a deep learning model to predict the risk stratification of all-cause death for older people with disability, providing guidance for long-term care plans. Based on the government-le...
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Open AccessSafety and immunogenicity of Ad5-nCoV immunization after three-dose priming with inactivated SARS-CoV-2 vaccine in Chinese adults
Data on the safety and immunity of a heterologous booster (fourth dose) after three-doses of inactivated SARS-CoV-2 vaccine in Chinese adults are limited. We evaluate the safety and immunogenicity of Ad5-nCoV ...
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Open AccessPublisher Correction: Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study
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Open AccessLong-term measles antibody profiles following different vaccine schedules in China, a longitudinal study
Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. Based on two prospective cohorts of ch...
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Open AccessAuthor Correction: Interpretable design of Ir-free trimetallic electrocatalysts for ammonia oxidation with graph neural networks
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Open AccessInterpretable design of Ir-free trimetallic electrocatalysts for ammonia oxidation with graph neural networks
The electrochemical ammonia oxidation to dinitrogen as a means for energy and environmental applications is a key technology toward the realization of a sustainable nitrogen cycle. The state-of-the-art metal c...
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Open AccessSeroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the Natio...
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Open AccessUltrafast inactivation of SARS-CoV-2 with 266 nm lasers
Disinfection eliminates pathogenic microorganisms and ensures a biosafe environment for human beings. The rapid spread of COVID-19 is challenging traditional disinfection methods in terms of reducing harmful s...
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Open AccessUntangling the changing impact of non-pharmaceutical interventions and vaccination on European COVID-19 trajectories
Non-pharmaceutical interventions (NPIs) and vaccination are two fundamental approaches for mitigating the coronavirus disease 2019 (COVID-19) pandemic. However, the real-world impact of NPIs versus vaccination...
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Open AccessTime-varying optimization of COVID-19 vaccine prioritization in the context of limited vaccination capacity
Dynamically adapting the allocation of COVID-19 vaccines to the evolving epidemiological situation could be key to reduce COVID-19 burden. Here we developed a data-driven mechanistic model of SARS-CoV-2 transm...
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Open AccessMultilayer stabilization for fabricating high-loading single-atom catalysts
Metal single-atom catalysts (M-SACs) have emerged as an attractive concept for promoting heterogeneous reactions, but the synthesis of high-loading M-SACs remains a challenge. Here, we report a multilayer stab...
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Open AccessDisease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
The novel coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, where the initial wave of intense community transmissions was cut short by interventions. Using multiple data sources, here we ...
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Open AccessMolecular basis for assembly of the shieldin complex and its implications for NHEJ
Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions as a bridge linking 53BP1-RIF1 and single-strand DNA to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). Howe...
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Open AccessPreoperative Serum Fibrinogen is Associated With Acute Kidney Injury after Cardiac Valve Replacement Surgery
Acute kidney injury (AKI) after open cardiac surgery is associated with a longer hospital stay and higher risk of mortality. We aimed to explore the association between preoperative serum fibrinogen level and ...
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Open AccessTranslational Inhibition of α-Neurexin 2
Neurexins are extensively investigated presynaptic cell-adhesion molecules which play important roles in transmitting signals and processing information at synapses that connect neurons into a vast network of ...
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Open AccessPatterns of human social contact and contact with animals in Shanghai, China
East Asia is as a principal hotspot for emerging zoonotic infections. Understanding the likely pathways for their emergence and spread requires knowledge on human-human and human-animal contacts, but such stud...
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Open AccessInter-annual variation in seasonal dengue epidemics driven by multiple interacting factors in Guangzhou, China
Vector-borne diseases display wide inter-annual variation in seasonal epidemic size due to their complex dependence on temporally variable environmental conditions and other factors. In 2014, Guangzhou, China ...
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Open AccessGlycolate oxidase gene family in Nicotiana benthamiana: genome-wide identification and functional analyses in disease resistance
Glycolate oxidase (GOX)-dependent production of H2O2 in response to pathogens and its function in disease resistance are still poorly understood. In this study, we performed genome-wide identification of GOX gene...
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Open AccessPretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
Cisplatin is a commonly used chemotherapeutic agent in the treatment of different types of malignant tumors, but nephrotoxicity limits its usage. Therefore, in this study, we aimed to determine the possible pr...
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Open AccessA Facile Approach to Prepare Multiple Heteroatom-Doped Carbon Materials from Imine-Linked Porous Organic Polymers
In this paper, we proposed a new strategy to prepare multiple heteroatom doped (N, P-doped) porous carbon materials with high surface area of ~1,535 m2 g−1 simply by pyrolysis of imine-linked porous organic polym...