8 Result(s)

Article

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

Hu Dong, Pan Liu, Manyuan Bai, Kang Wang, Rui Feng, Dandan Zhu, Yao Sun… in Protein & Cell (2022)

Article

Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation

Nan Wang, Wenyuan Chen, Ling Zhu, Dongjie Zhu, Rui Feng, Jialing Wang… in Protein & Cell (2020)

Article

Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation

Genome packaging is a fundamental process in a viral life cycle and a prime target of antiviral drugs. Herpesviruses use an ATP-driven packaging motor/terminase complex to translocate and cleave concatemeric d...

Yunxiang Yang, Pan Yang, Nan Wang, Zhonghao Chen, Dan Su, Z. Hong Zhou… in Protein & Cell (2020)

Article

The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection

Entero virus 71 (EV71) causes hand, foot, and mouth disease (HFMD) and occasionally leads to severe neurological complications and even death. Scavenger receptor class B member 2 (SCARB2) is a functional recep...

Xuyuan Zhang, Pan Yang, Nan Wang, Jialong Zhang, **gyun Li, Hao Guo… in Protein & Cell (2017)

Article

TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope

Ebolavirus can cause hemorrhagic fever in humans with a mortality rate of 50%–90%. Currently, no approved vaccines and antiviral therapies are available. Human TIM1 is considered as an at...

Shuai Yuan, Lei Cao, Hui Ling, Minghao Dang, Yao Sun, Xuyuan Zhang… in Protein & Cell (2015)

Article

Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71

Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models ...

Minghao Dang, **angxi Wang, Quan Wang, Yaxin Wang, Jian** Lin, Yuna Sun… in Protein & Cell (2014)

Article

An open conformation determined by a structural switch for 2A protease from coxsackievirus A16

Coxsackievirus A16 belongs to the family Picornaviridae, and is a major agent of hand-foot-and-mouth disease that infects mostly children, and to date no vaccines or antiviral therapies are available. 2A protease...

Yao Sun, **angxi Wang, Shuai Yuan, Minghao Dang, Xuemei Li… in Protein & Cell (2013)

Article

Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c

Disulfide bond-forming (Dsb) protein is a bacterial periplasmic protein that is essential for the correct folding and disulfide bond formation of secreted or cell wallassociated proteins. DsbA introduces disul...

Lu Wang, Jun Li, **angxi Wang, Wu Liu, Xuejun C. Zhang, Xuemei Li… in Protein & Cell (2013)