14 Result(s)
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Article
Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding ...
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Open AccessStructural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies
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Article
Ferritinophagy is Involved in Experimental Subarachnoid Hemorrhage-Induced Neuronal Ferroptosis
Ferroptosis is a novel form of regulated cell death involved in the pathophysiological process of experimental subarachnoid hemorrhage (SAH), but how neuronal ferroptosis occurs remains unknown. In this study,...
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Open AccessStructures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation
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Open AccessArchitecture of the herpesvirus genome-packaging complex and implications for DNA translocation
Genome packaging is a fundamental process in a viral life cycle and a prime target of antiviral drugs. Herpesviruses use an ATP-driven packaging motor/terminase complex to translocate and cleave concatemeric d...
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Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury
Anisodamine protects against free radical-induced cellular damage. This study aimed to investigate the protective effect of anisodamine on rhabdomyolysis-induced acute kidney injury (RIAKI). C57BL/6 J mice, TXNIP
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Article
Open AccessThe binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection
Entero virus 71 (EV71) causes hand, foot, and mouth disease (HFMD) and occasionally leads to severe neurological complications and even death. Scavenger receptor class B member 2 (SCARB2) is a functional recep...
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The Rab1 in host cells modulates Brucella intracellular survival and binds to Brucella DnaK protein
The intracellular pathogen Brucella abortus (B. abortus) survives and replicates inside host cells within the Brucella-containing vacuole, in which membrane contains a small GTPase Rab1. Here, we reported that Ra...
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Open AccessTIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope
Ebolavirus can cause hemorrhagic fever in humans with a mortality rate of 50%–90%. Currently, no approved vaccines and antiviral therapies are available. Human TIM1 is considered as an at...
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Open AccessMolecular mechanism of SCARB2-mediated attachment and uncoating of EV71
Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models ...
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Article
More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules
Enterovirus HEV71 is responsible for recurring epidemics in develo** countries. New structural analyses coupled with in silico docking methods have allowed for the generation of potent inhibitors of viral-envel...
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An open conformation determined by a structural switch for 2A protease from coxsackievirus A16
Coxsackievirus A16 belongs to the family Picornaviridae, and is a major agent of hand-foot-and-mouth disease that infects mostly children, and to date no vaccines or antiviral therapies are available. 2A protease...
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Article
Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c
Disulfide bond-forming (Dsb) protein is a bacterial periplasmic protein that is essential for the correct folding and disulfide bond formation of secreted or cell wallassociated proteins. DsbA introduces disul...
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Article
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of the mature virus and natural empty particles reveals...
