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1,122 Result(s)
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Article
SPD-YOLOv8: an small-size object detection model of UAV imagery in complex scene
Traditional camera sensors rely on human observation. However, in complex scenes, people often experience fatigue when observing objects of various sizes. Moreover, human cognitive abilities have inherent limi...
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Open AccessUltrabroadband valley transmission and corner states in valley photonic crystals with dendritic structure
In photonic crystal systems, topologically protected edge states and corner states can be achieved by breaking spatial inversion symmetry, which is expected to be applied to topologically protected lasers, opt...
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Open AccessPharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders
Medications are urgently needed to treat symptoms of drug withdrawal and mitigate dysphoria and psychiatric comorbidities that drive opioid abuse and relapse. ITI-333 is a novel molecule in development for tre...
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Metal complexes of bipyridine-functionalized covalent organic frameworks as efficient electrocatalysts for oxygen evolution reaction
Electrocatalytic water splitting is considered a clean and practical method for producing energy. In this study, COF-Bpy, a bipyridine-functionalized covalent organic framework (COF), was prepared via post-syn...
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Open AccessWhich factors are associated with adverse prognosis in multiple myeloma patients after surgery? - preliminary establishment and validation of the nomogram
To investigate the prognosis of patients with Multiple Myeloma (MM) after surgery, analyze the risk factors leading to adverse postoperative outcomes, and establish a nomogram.
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Prenatal Inflammatory Exposure Predisposes Offspring to Chronic Kidney Diseases Via the Activation of the eIF2α-ATF4 Pathway
It has recently become more recognized that renal diseases in adults can originate from adverse intrauterine (maternal) environmental exposures. Previously, we found that prenatal lipopolysaccharide (LPS) expo...
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The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been associated with potential cardiovascular benefits, partly attributed to their bioactive metabolites. However, the underlying mechanisms responsible for...
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Open AccessCholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated promising efficacy in early trials for relapsed/refractory diffuse large B cell lymphoma (DLBCL). However, its efficacy in treating primary ref...
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Open AccessThe comparison of white-to-white via triple person-times caliper measuring and machine-measuring in V4c implantable collamer lens implantation
This study aimed to compare the differences and characteristics of white-to-white (WTW) values obtained before V4c implantation using triple person-times caliper, IOL-Master 700, Pentacam HR, and UBM, and to a...
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Open AccessMitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption
Interactions between osteolineage cells and myeloid cells play important roles in maintaining skeletal homeostasis. Herein, we find that osteolineage cells transfer mitochondria to myeloid cells. Impairment of...
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Article
MWformer: a novel low computational cost image restoration algorithm
The development of the Internet of Things has led to a surge in edge devices. The image detection algorithm, one of the commonly used algorithms in edge computing, is affected by environments such as weather, ...
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Open AccessAttenuation of osteoarthritis progression via locoregional delivery of Klotho-expressing plasmid DNA and Tanshinon IIA through a stem cell-homing hydrogel
Osteoarthritis (OA) is an aging-related degenerative joint disorder marked by joint discomfort and rigidity. Senescent chondrocytes release pro-inflammatory cytokines and extracellular matrix-degrading protein...
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Leveraging crystal symmetry for thermoelectric performance optimization in cubic GeSe
In thermoelectrics, the manipulation of crystal symmetry is instrumental in optimizing the electrical and thermal transport parameters. Within this context, the present study explored the largely overlooked hi...
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Open AccessShort-term culture for rapid identification by mass spectrometry and automated antimicrobial susceptibility testing from positive bottles
Early and appropriate antibiotic treatment improves the clinical outcome of patients with sepsis. There is an urgent need for rapid identification (ID) and antimicrobial susceptibility testing (AST) of bacteri...
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Enhanced Grain Refining Effect of Mg–Zr Master Alloy on Magnesium Alloys via a Synergistic Strategy Involving Heterogeneous Nucleation and Solute-Driven Growth Restriction
Zirconium (Zr) emerges as the most effective grain refiner for magnesium (Mg) alloys incorporating Zr. Typically, Zr is introduced in the form of an Mg–Zr master alloy. However, within Mg–Zr master alloys, Zr ...
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A state-of-the-art review on delayed expansion of cemented paste backfill materials
Utilizing delayed expansion cemented paste backfill materials (DECPB) in mine backfill operations offers an effective solution to the challenge of achieving proper contact between the in-situ cemented backfill...
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ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and regulates the Warburg effect in breast cancer
Pyruvate kinase M2 (PKM2) is a central metabolic enzyme driving the Warburg effect in tumor growth. Previous investigations have demonstrated that PKM2 is subject to O-linked β-N-acetylglucosamine (O-GlcNAc) m...
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Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis
Osteoarthritis (OA) is a prevalent chronic condition that primarily impacts the articular cartilage and surrounding bone tissue, resulting in joint inflammation and structural deterioration. The etiology of OA...
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Article
TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation
Non-alcoholic steatohepatitis (NASH) is rapidly surpassing viral hepatitis as the primary cause of hepatocellular carcinoma (HCC). However, understanding of NASH-progressed HCC remains poor, which might impede...
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Open AccessA lightweight contour detection network inspired by biology
In recent years, the field of bionics has attracted the attention of numerous scholars. Some models combined with biological vision have achieved excellent performance in computer vision and image processing t...