15 Result(s)
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Article
Open AccessAPC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation
The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a nor...
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Article
Role of P53 Mediated Molecular Regulation in Starvation-Induced Autophagy in HCT-116 and HT-29 Colorectal Carcinoma Cells
The tumor suppressor P53 is a known regulator of autophagy, which has been reported to be associated with colorectal cancer (CRC) cells’ drug resistance. However, the molecular mechanisms of P53 regulating aut...
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Open AccessIGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer ...
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Article
Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast–myofibroblast differentiation and myocardial fibrosis
The transdifferentiation from cardiac fibroblasts to myofibroblasts is an important event in the initiation of cardiac fibrosis. However, the underlying mechanism is not fully understood. Circ-sh3rf3 (circular...
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Open AccessRetraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway
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Open AccessTargeting NAD+: is it a common strategy to delay heart aging?
Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numero...
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Open AccessUpregulation of lncRNA NONRATG019935.2 suppresses the p53-mediated apoptosis of renal tubular epithelial cells in septic acute kidney injury
Although increasing evidence has confirmed that the apoptosis of renal tubular epithelial cells (RTECs) is a crucial contributor to the onset and development of septic acute kidney injury (AKI), the pathologic...
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Open AccessRETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway
Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the ro...
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Article
ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation
α-Tubulin acetyltransferase 1 (ATAT1) catalyzes acetylation of α-tubulin at lysine 40 in various organisms ranging from Tetrahymena to humans. Despite the importance in mammals suggested by studies of cultured ce...
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Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment
Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitato...
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Open AccessIschemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia
Ischemic postconditioning provides robust neuroprotection, therefore, determining the molecular events may provide promising targets for stroke treatment. Here, we showed that the expression of functional mito...
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Open AccessInterferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells
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Article
Tubulin acetylation: responsible enzymes, biological functions and human diseases
Microtubules have important functions ranging from maintenance of cell morphology to subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the organismal level, microtub...
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Covalent Protein Modification as a Mechanism for Dynamic Recruitment of Specific Interactors
The dynamic interchange of information within a cell, which subsumes the regulation of protein function, activity and multiprotein complex membership, depends upon the flux of the sets of modifications of prot...
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Article
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
In the past decade, protein Lys acetylation has emerged as a major post-translational modification that occurs even in bacteria. This modification not only reg...
