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Article
Density-Equicontinuity and Density-Sensitivity of Discrete Amenable Group Actions
Let (X, G) be a G-system which means that X is a compact metric space and G is an amenable group continuously acting on X. In this paper, we introduce the notions of density-equicontinuity with respect to a given...
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Article
Equicontinuity and Sensitivity of Group Actions
Let (X, G) be a dynamical system (G-system for short), that is, X is a topological space and G is an infinite topological group continuously acting on X. In the paper, the authors introduce the concepts of Hausdo...
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Article
Open AccessA mass spectrum-oriented computational method for ion mobility-resolved untargeted metabolomics
Ion mobility (IM) adds a new dimension to liquid chromatography-mass spectrometry-based untargeted metabolomics which significantly enhances coverage, sensitivity, and resolving power for analyzing the metabol...
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Article
Open AccessPublisher Correction: Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer
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Open AccessSerum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer
Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for patients with locally advanced rectal cancer (LARC). Therapeutic efficacy of nCRT is significantly affected by treatment-induced diarr...
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Article
On Mean Sensitive Tuples of Discrete Amenable Group Actions
Let (X, G) be a G-system which means that X is a perfect compact metric space and G is a countable discrete infinite amenable group continuously acting on X. In this paper, for an invariant measure ...
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Article
Open AccessMetabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Liquid chromatography - mass spectrometry (LC-MS) based untargeted metabolomics allows to measure both known and unknown metabolites in the metabolome. However, unknown metabolite annotation is a major challen...
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Article
Optimization on the multi-period empty container repositioning problem in regional port cluster based upon inventory control strategies
Within the area of regional port clusters, this paper establishes a multi-period mixed integer programming model to optimize the empty container repositioning between public hinterlands and ports, comprehensiv...
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Article
Open AccessGlobal stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila
System-wide metabolic homeostasis is crucial for maintaining physiological functions of living organisms. Stable-isotope tracing metabolomics allows to unravel metabolic activity quantitatively by measuring th...
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Article
Open AccessUSP1-trap** lesions as a source of DNA replication stress and genomic instability
The deubiquitinase USP1 is a critical regulator of genome integrity through the deubiquitylation of Fanconi Anemia proteins and the DNA replication processivity factor, proliferating cell nuclear antigen (PCNA...
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Article
Investigating plant chemicals and trade-offs between adult preference and larval performance of the rice water weevil
Herbivores use plant chemicals for host plant selection to maximize their own and/or offspring performance. Since host plants that are optimal for mother and offspring are often different and spatially/tempora...
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Article
Open AccessAltered synthesis of genes associated with short-chain fatty acids in the gut of patients with atrial fibrillation
The gut microbiota provides health benefits in humans by producing short-chain fatty acids (SCFAs), whose deficiency causes multiple disorders and inflammatory diseases. However, gut bacteria producing SCFAs i...
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Article
Open AccessIon mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain
Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging brain and aging-dependent disorders such as neurodegenerative diseases. There is an unmet demand to comprehensively p...
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Article
Microhabitat separation between the pest aphids Rhopalosiphum padi and Sitobion avenae: food resource or microclimate selection?
Niche separation between competing species is a central issue in ecology. As two of the most important pests worldwide of cereal production, Rhopalosiphum padi primarily dominates stems and basal leaves of wheat ...
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Article
Open AccessModeling human activity dynamics: an object-class oriented space–time composite model based on social media and urban infrastructure data
Modeling human activity dynamics is important for many application domains. However, there are problems inherent in modeling population information, since the number of people inside a given area can change dy...
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Article
Open AccessSingle-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
Guanine-rich DNA sequences occur throughout the human genome and can transiently form G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic instability. Here, we apply multi-color ...
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Article
On sensitive sets and regionally proximal sets of group actions
We introduce the concepts of S-sets and Q-sets for a flow (a group action on a compact metric space) and prove that a transitive flow is sensitive if and only if there exists an S-set with cardinality more than 2...
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Article
Open AccessIon mobility collision cross-section atlas for known and unknown metabolite annotation in untargeted metabolomics
The metabolome includes not just known but also unknown metabolites; however, metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility – mass spectrometry (IM-MS) has emerged as a ...
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Article
Open AccessMetagenomic data-mining reveals enrichment of trimethylamine-N-oxide synthesis in gut microbiome in atrial fibrillation patients
The gut bacteria-derived metabolite trimethylamine-N-oxide (TMAO) has been discussed in various cardiometabolic diseases. However, evidence characterizing the microbial population responsible for TMAO accumula...
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Article
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus formation. We demonstrate that induction of ...
