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Open AccessSHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition
Despite the promising antitumor activity of SHP2 inhibitors in RAS-dependent tumours, overall responses have been limited by their narrow therapeutic window. Like with all MAPK pathway inhibitors, this is like...
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Open AccessUSP1-trap** lesions as a source of DNA replication stress and genomic instability
The deubiquitinase USP1 is a critical regulator of genome integrity through the deubiquitylation of Fanconi Anemia proteins and the DNA replication processivity factor, proliferating cell nuclear antigen (PCNA...
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Monitoring genome-wide replication fork directionality by Okazaki fragment sequencing in mammalian cells
The ability to monitor DNA replication fork directionality at the genome-wide scale is paramount for a greater understanding of how genetic and environmental perturbations can impact replication dynamics in hu...
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Open AccessOTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex
Systematic control of the transforming growth factor-β (TGFβ) pathway is essential to keep the amplitude and the intensity of downstream signalling at appropriate levels. Ubiquitination plays a crucial role in...
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Open AccessAuthor Correction: c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open Accessc-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
Treatment of muscle-invasive bladder cancer remains a major clinical challenge. Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer correlating with cancer progression and i...
